Promoted Relationship of Cardiovascular Morbidity with Air Pollutants in a Typical Chinese Urban Area

Background A large number of studies about effects of air pollutants on cardiovascular mortality have been conducted; however, those investigating association between air pollutants and cardiovascular morbidity are limited, especially in developing countries. Methods A time-series analysis on the short-term association between outdoor air pollutants including particulate matter (PM) with diameters of 10 µm or less (PM10), sulfur dioxide (SO2) and nitrogen dioxide (NO2) and cardiovascular morbidity was conducted in Tianjin, China based on 4 years of daily data (2008–2011). The morbidity data were stratified by sex and age. The effects of air pollutants during the warm season and the cool season were also analyzed separately. Results Each increase in PM10, SO2, and NO2 by increments of 10 µg/m3 in a 2-day average concentration was associated with increases in the cardiovascular morbidity of 0.19% with 95 percent confidence interval (95% CI) of 0.08–0.31, 0.43% with 95% CI of 0.03–0.84, and 0.52% with 95% CI of −0.09–1.13, respectively. The effects of air pollutants were more evident in the cool season than those in the warm season, females and the elderly were more vulnerable to outdoor air pollution. Conclusions All estimated coefficients of PM10, SO2 and NO2 are positive but only the effect of SO2 implied statistical significance at the 5% level. Moreover, season, sex and age might modify health effects of outdoor air pollutants. This work may bring inspirations for formulating local air pollutant standards and social policy regarding cardiovascular health of residents.

[1]  Yinchang Feng,et al.  Vertical characteristics and source identification of PM10 in Tianjin. , 2012, Journal of environmental sciences.

[2]  S. Roberts Can mortality displacement mask thresholds in the concentration-response relation between particulate matter air pollution and mortality? , 2011 .

[3]  Stefan Ma,et al.  A tale of two cities: effects of air pollution on hospital admissions in Hong Kong and London compared. , 2001, Environmental health perspectives.

[4]  R Hemalatha,et al.  Fish protein hydrolysates: proximate composition, amino acid composition, antioxidant activities and applications: a review. , 2012, Food chemistry.

[5]  Ovcharov Vk International Classification of Diseases, Tenth Revision. , 1995, Epidemiological bulletin.

[6]  Yuming Guo,et al.  The short-term effect of air pollution on cardiovascular mortality in Tianjin, China: comparison of time series and case-crossover analyses. , 2010, The Science of the total environment.

[7]  Who Europe Air Quality Guidelines Global Update 2005: Particulate Matter, ozone, nitrogen dioxide and sulfur dioxide , 2006 .

[8]  Katsumi Yoshida,et al.  S12 AMBIENT AIR QUALITY STANDARDS , 1988 .

[9]  Shilu Tong,et al.  Ambient air pollution, climate change, and population health in China. , 2012, Environment international.

[10]  Xiangang Hu,et al.  Health and ecosystem risks of graphene. , 2013, Chemical reviews.

[11]  S. Moolgavkar Air Pollution and Hospital Admissions for Diseases of the Circulatory System in Three U.S. Metropolitan Areas , 2000, Journal of the Air & Waste Management Association.

[12]  Antonella Zanobetti,et al.  Temperature and Mortality in Nine US Cities , 2008, Epidemiology.

[13]  Shuxiao Wang,et al.  Characteristics and health impacts of particulate matter pollution in China (2001–2011) , 2013 .

[14]  T. Hagen,et al.  Reduced life expectancy after an incident hospital diagnosis of acute myocardial infarction--effects of smoking in women and men. , 2013, International journal of cardiology.

[15]  H. Kan,et al.  Season, Sex, Age, and Education as Modifiers of the Effects of Outdoor Air Pollution on Daily Mortality in Shanghai, China: The Public Health and Air Pollution in Asia (PAPA) Study , 2008, Environmental health perspectives.

[16]  W. Frishman,et al.  Air Pollution Exposure as a Risk Factor for Cardiovascular Disease Morbidity and Mortality , 2014, Cardiology in review.

[17]  J Schwartz,et al.  Confounding and Effect Modification in the Short-Term Effects of Ambient Particles on Total Mortality: Results from 29 European Cities within the APHEA2 Project , 2001, Epidemiology.

[18]  L. Folinsbee Human health effects of air pollution. , 1993, Environmental health perspectives.

[19]  Scott L Zeger,et al.  Temperature and mortality in 11 cities of the eastern United States. , 2002, American journal of epidemiology.

[20]  Li Chen,et al.  Characteristics of Major PM2.5 Components during Winter in Tianjin, China , 2009 .

[21]  F. Kelly Dietary antioxidants and environmental stress , 2004, Proceedings of the Nutrition Society.

[22]  K. Yoshida,et al.  Ambient air quality standards. , 1988, The Journal of toxicological sciences.

[23]  Chang-Chuan Chan,et al.  Traffic-related air pollution and cardiovascular mortality in central Taiwan. , 2010, The Science of the total environment.

[24]  H. Kan,et al.  Prospective Analysis of Traffic Exposure as a Risk Factor for Incident Coronary Heart Disease: The Atherosclerosis Risk in Communities (ARIC) Study , 2008, Environmental health perspectives.

[25]  David C. Christiani,et al.  A Systematic Review of Occupational Exposure to Particulate Matter and Cardiovascular Disease , 2010, International journal of environmental research and public health.

[26]  P. Gallaher,et al.  Tobacco use among youth and adults in Mainland China: the China Seven Cities Study. , 2006, Public health.

[27]  A. Peters,et al.  Particulate Matter Air Pollution and Cardiovascular Disease: An Update to the Scientific Statement From the American Heart Association , 2010, Circulation.

[28]  K. Shrey,et al.  Air pollutants: the key stages in the pathway towards the development of cardiovascular disorders. , 2011, Environmental toxicology and pharmacology.

[29]  S. Roberts,et al.  Combining data from multiple monitors in air pollution mortality time series studies , 2003 .