The blood-brain barrier protects foreign antigens in the brain from immune attack

[1]  B J Hoffer,et al.  Human fetal dopamine neurons grafted into the striatum in two patients with severe Parkinson's disease. A detailed account of methodology and a 6-month follow-up. , 1989, Archives of neurology.

[2]  R. Lund,et al.  Degeneration of optic axons induces the expression of major histocompatibility antigens , 1989, Brain Research.

[3]  R. Lund,et al.  Integrity of the blood‐brain barrier in retinal xenografts is correlated with the immunological status of the host , 1989, The Journal of comparative neurology.

[4]  W. Freed,et al.  Immunological reactions induced by intracerebral transplantation: Evidence that host microglia but not astroglia are the antigen-presenting cells , 1989, Experimental Neurology.

[5]  P. Bartlett,et al.  The immune response to intraparenchymal fetal CNS transplants. , 1989, Transplantation proceedings.

[6]  P. Bartlett,et al.  Expression of MHC antigens in the central nervous system. , 1989, Transplantation proceedings.

[7]  Patrik Brundin,et al.  Immunological aspects of grafting in the mammalian central nervous system. A review and speculative synthesis , 1988, Brain Research Reviews.

[8]  H. Konno,et al.  Sequelae of the osmotic blood-brain barrier opening in rats. , 1988, Journal of neurosurgery.

[9]  R. Lund,et al.  INSTABILITY OF NEURAL XENOGRAFTS PLACED IN NEONATAL RAT BRAINS , 1988, Transplantation.

[10]  S. Wiegand,et al.  Characteristics of vasculature and neurovascular relations in intraventricular anterior hypothalamic transplants , 1988, Brain Research Bulletin.

[11]  R. Sobel,et al.  Major Histocompatibility Complex Molecule Expression in the Human Central Nervous System: Immunohistochemical Analysis of 40 Patients , 1988, Journal of neuropathology and experimental neurology.

[12]  V. Perry,et al.  Modulation of CD4 antigen on macrophages and microglia in rat brain , 1987, The Journal of experimental medicine.

[13]  J. Antel,et al.  Rejection of fetal neocortical neural transplants by H-2 incompatible mice. , 1987, Journal of immunology.

[14]  U. Traugott.  Multiple sclerosis: relevance of Class I and Class II MHC-expressing cells to lesion development , 1987, Journal of Neuroimmunology.

[15]  P. Mcgeer,et al.  Reactive microglia in patients with senile dementia of the Alzheimer type are positive for the histocompatibility glycoprotein HLA-DR , 1987, Neuroscience Letters.

[16]  M. Cuzner,et al.  Microglia are the major cell type expressing MHC class II in human white matter , 1987, Journal of the Neurological Sciences.

[17]  D. Silberberg,et al.  MHC antigen expression on bulk isolated macrophage-microglia from newborn mouse brain: induction of Ia antigen expression by γ-interferon , 1987, Journal of Neuroimmunology.

[18]  R. Lund,et al.  Transplantation of Retina and Visual Cortex to Rat Brains of Different Ages , 1987, Annals of the New York Academy of Sciences.

[19]  M. Salcman,et al.  Angioarchitecture of the CNS, pituitary gland, and intracerebral grafts revealed with peroxidase cytochemistry , 1987, The Journal of comparative neurology.

[20]  W. Hickey,et al.  Graft-vs.-host disease elicits expression of class I and class II histocompatibility antigens and the presence of scattered T lymphocytes in rat central nervous system. , 1987, Proceedings of the National Academy of Sciences of the United States of America.

[21]  J. Rosenstein.  Neocortical transplants in the mammalian brain lack a blood-brain barrier to macromolecules. , 1987, Science.

[22]  S. Nishio,et al.  Hyperosmotic blood-brain barrier disruption in brains of rats with an intracerebrally transplanted RG-C6 tumor. , 1987, Journal of neurosurgery.

[23]  H. Lassmann,et al.  Cellular immune reactivity within the CNS , 1986, Trends in Neurosciences.

[24]  K. Shimokata,et al.  Induction of human leukocyte antigen-A,B,C and -DR on cultured human oligodendrocytes and astrocytes by human γ-interferon , 1986, Neuroscience Letters.

[25]  J. Blanks,et al.  Vascular atrophy in the retinal degenerative rd mouse , 1986, The Journal of comparative neurology.

[26]  S. Rapoport,et al.  Tight‐Junctional Modification as the Basis of Osmotic Opening of the Blood‐Brain Barrier a , 1986, Annals of the New York Academy of Sciences.

[27]  D. Mason,et al.  The fate of allogeneic and xenogeneic neuronal tissue transplanted into the third ventricle of rodents , 1986, Neuroscience.

[28]  J. Whelan,et al.  Expression of mouse beta 2-microglobulin in frozen and formaldehyde-fixed central nervous tissues: comparison of tissue behind the blood-brain barrier and tissue in a barrier-free region. , 1986, Journal of immunology.

[29]  N. Tribolet,et al.  Expression of class II major histocompatibility antigens on reactive astrocytes and endothelial cells within the gliosis surrounding metastases and abscesses , 1986, Journal of Neuroimmunology.

[30]  W. Hickey,et al.  Monoclonal antibody analysis of MHC expression in human brain biopsies: tissue ranging from "histologically normal" to that showing different levels of glial tumor involvement. , 1986, Journal of immunology.

[31]  D. Silberberg,et al.  The expression of MHC antigens on oligodendrocytes: Induction of polymorphic H-2 expression by lymphokines , 1986, Journal of Neuroimmunology.

[32]  G. Moretto,et al.  Expression of Ia antigens on the surface of human oligodendrocytes and astrocytes in culture , 1985, Journal of Neuroimmunology.

[33]  W. Fierz,et al.  Astrocytes as antigen-presenting cells. I. Induction of Ia antigen expression on astrocytes by T cells via immune interferon and its effect on antigen presentation. , 1985, Journal of immunology.

[34]  H. Wekerle,et al.  T-LINE MEDIATED EAE - A MORPHOLOGICAL STUDY OF DEVELOPING LESIONS , 1985 .

[35]  S. Geyer,et al.  IMMUNOGENETIC ASPECTS OF TRANSPLANTATION IN THE RAT BRAIN , 1985, Transplantation.

[36]  S. Ferrone,et al.  Distribution of human Class I (HLA-A,B,C) histocompatibility antigens in normal and malignant tissues of nonlymphoid origin. , 1984, Cancer research.

[37]  S. Fuggle,et al.  THE DETAILED DISTRIBUTION OF MHC CLASS II ANTIGENS IN NORMAL HUMAN ORGANS , 1984, Transplantation.

[38]  E P Frenkel,et al.  Osmotic blood-brain barrier modification and combination chemotherapy: concurrent tumor regression in areas of barrier opening and progression in brain regions distant to barrier opening. , 1984, Neurosurgery.

[39]  S. Fuggle,et al.  THE DETAILED DISTRIBUTION OF HLA‐A, B, C ANTIGENS IN NORMAL HUMAN ORGANS , 1984, Transplantation.

[40]  I. Cohen,et al.  Activated T lymphocytes produce a matrix-degrading heparan sulphate endoglycosidase , 1984, Nature.

[41]  R. Colvin,et al.  The immunopathology of experimental allergic encephalomyelitis. II. Endothelial cell Ia increases prior to inflammatory cell infiltration. , 1984, Journal of immunology.

[42]  M. Hamou,et al.  Demonstration of HLA-DR antigens in normal human brain. , 1984, Journal of neurology, neurosurgery, and psychiatry.

[43]  Z. Fuks,et al.  Interaction of T lymphocytes and macrophages with cultured vascular endothelial cells: Attachment, invasion, and subsequent degradation of the subendothelial extracellular matrix , 1984, Journal of cellular physiology.

[44]  E. Mugnaini,et al.  Zinc-aldehyde fixation for light-microscopic immunocytochemistry of nervous tissues. , 1983, The journal of histochemistry and cytochemistry : official journal of the Histochemistry Society.

[45]  C. Goridis,et al.  Expression of Ia antigens by cultured astrocytes treated with gamma-interferon , 1983, Neuroscience Letters.

[46]  E. Reinherz,et al.  Immunohistochemical staining of human brain with monoclonal antibodies that identify lymphocytes, monocytes, and the Ia antigen , 1983, Journal of Neuroimmunology.

[47]  M. Bradbury,et al.  Factors influencing exit of substances from cerebrospinal fluid into deep cervical lymph of the rabbit. , 1983, The Journal of physiology.

[48]  E. Frenkel,et al.  Successful treatment of primary central nervous system lymphomas with chemotherapy after osmotic blood-brain barrier opening , 1983 .

[49]  S. Hsu,et al.  Color modification of diaminobenzidine (DAB) precipitation by metallic ions and its application for double immunohistochemistry. , 1982, The journal of histochemistry and cytochemistry : official journal of the Histochemistry Society.

[50]  F. Gage,et al.  Cross-species neural grafting in a rat model of Parkinson's disease , 1982, Nature.

[51]  E. Frenkel,et al.  Delivery of hexosaminidase A to the cerebrum after osmotic modification of the blood--brain barrier. , 1981, Proceedings of the National Academy of Sciences of the United States of America.

[52]  John,et al.  Demonstration and characterization of Ia-positive dendritic cells in the interstitial connective tissues of rat heart and other tissues, but not brain , 1981, The Journal of experimental medicine.

[53]  L. Weiner,et al.  Expression and synthesis of murine immune response-associated (Ia) antigens by brain cells. , 1981, Proceedings of the National Academy of Sciences of the United States of America.

[54]  E. Frenkel,et al.  Reversible osmotic blood-brain barrier disruption in humans: implications for the chemotherapy of malignant brain tumors. , 1980, Neurosurgery.

[55]  P. Morris,et al.  Distribution and quantitation of HLA-ABC and DR (Ia) antigens on human kidney and other tissues. , 1980, Transplantation.

[56]  I. Hüttner,et al.  Opening of tight junctions in cerebral endothelium. I. Effect of hyperosmolar mannitol infused through the internal carotid artery , 1979, The Journal of comparative neurology.

[57]  L. Sokoloff,et al.  Osmotic opening of the blood‐brain barrier and local cerebral glucose utilization , 1979, Annals of neurology.

[58]  K. Pettigrew,et al.  Osmotic opening of the blood-brain barrier in the rhesus monkey without measurable brain edema , 1977, Brain Research.

[59]  S. Raju,et al.  Immunologic study of the brain as a privileged site. , 1977, Transplantation proceedings.

[60]  R. Sidman,et al.  Distribution of H-2 alloantigen in adult and developing mouse brain. , 1973, Brain research.

[61]  S. Rapoport,et al.  Osmotic Opening of the Blood-Brain Barrier in the Monkey without Associated Neurological Deficits , 1973, Science.

[62]  J. Vanderhaeghen,et al.  An acidic protein isolated from fibrous astrocytes. , 1971, Brain research.

[63]  L. Scheinberg,et al.  Is the brain "an immunologically privileged site"? 3. Studies based on homologous skin grafts to the brain and subcutaneous tissues. , 1966, Archives of neurology.

[64]  D. Steinmuller.  Transplantation immunity in the newborn rat. I. The response at birth and maturation of response capacity. , 1961, The Journal of experimental zoology.

[65]  P. Medawar,et al.  ‘Actively Acquired Tolerance’ of Foreign Cells , 1953, Nature.

[66]  P. Medawar.  Immunity to homologous grafted skin; the fate of skin homografts transplanted to the brain, to subcutaneous tissue, and to the anterior chamber of the eye. , 1948, British journal of experimental pathology.

[67]  R. A. Willis.  Experiments on the Intracerebral Implantation of Embryo Tissues in Rats , 1935 .

[68]  James B. Murphy,et al.  CONDITIONS DETERMINING THE TRANSPLANTABILITY OF TISSUES IN THE BRAIN , 1923, The Journal of experimental medicine.

[69]  R. Lund,et al.  MHC antigen expression in spontaneous and induced rejection of neural xenografts. , 1990, Progress in brain research.

[70]  Scott T. Grafton,et al.  Therapeutic effects of human fetal dopamine cells transplanted in a patient with Parkinson's disease. , 1990, Progress in brain research.

[71]  A. Björklund,et al.  Immunological aspects of neural grafting in the mammalian central nervous system. , 1988, Progress in brain research.

[72]  W. Freed,et al.  Chapter 30 Intraventricular brain allografts and xenografts: studies of survival and rejection with and without systemic sensitization , 1988 .

[73]  G. Wong,et al.  Inducible expression of H–2 and Ia antigens on brain cells , 1984, Nature.

[74]  S. Rapoport,et al.  Osmotic blood-brain barrier disruption: pharmacodynamic studies in dogs and a clinical phase I trial in patients with malignant brain tumors. , 1981, Cancer treatment reports.

[75]  S. Rapoport,et al.  Modification of the blood-brain barrier: increased concentration and fate of enzymes entering the brain. , 1979, Proceedings of the National Academy of Sciences of the United States of America.