Study on rotational and unclogging motions of magnetic chain-like microrobot

Magnetic microrobotics was nowadays one of the most advanced technique to reach deep locations in human body for future biomedical applications. Different magnetic microrobot designs were proposed, such as bead pulling or microswimmers. In this paper, the use of chain-like of magnetic N-microspheres was investigated to enable new kind of motions and applications. An accurate theoretical model of chain-like magnetic microbeads navigating in viscous fluidic environments is described. Thus, the behavior of such microrobot was analyzed for different number of microspheres (ranging from N = 2 to 5). The efficiency of the proposed technique was demonstrated experimentally in a microfluidic vessel phantom to mimic atherosclerosis disease leading to plaque formation that fully occluded a vasculature.

[1]  J. W. Maccoll Aerodynamics of a Spinning Sphere , 1928, The Journal of the Royal Aeronautical Society.

[2]  Q. Pankhurst,et al.  Applications of magnetic nanoparticles in biomedicine , 2003 .

[3]  Jake J. Abbott,et al.  How Should Microrobots Swim? , 2009 .

[4]  Sukho Park,et al.  Two-dimensional locomotion of a microrobot with a novel stationary electromagnetic actuation system , 2009 .

[5]  Jake J. Abbott,et al.  Robotics in the Small, Part I: Microbotics , 2007, IEEE Robotics & Automation Magazine.

[6]  Antoine Ferreira,et al.  Endovascular Magnetically Guided Robots: Navigation Modeling and Optimization , 2012, IEEE Transactions on Biomedical Engineering.

[7]  Steven N. Rogak,et al.  Stokes drag on self-similar clusters of spheres , 1990 .

[8]  Antoine Ferreira,et al.  Control of a magnetic microrobot navigating in microfluidic arterial bifurcations through pulsatile and viscous flow , 2012, 2012 IEEE/RSJ International Conference on Intelligent Robots and Systems.

[9]  Sylvain Martel,et al.  Real-Time MRI-Based Control of a Ferromagnetic Core for Endovascular Navigation , 2008, IEEE Transactions on Biomedical Engineering.

[10]  Li Zhang,et al.  Bio-inspired magnetic swimming microrobots for biomedical applications. , 2013, Nanoscale.

[11]  Li Zhang,et al.  Controlled propulsion and cargo transport of rotating nickel nanowires near a patterned solid surface. , 2010, ACS nano.

[12]  Andreas Hölzer,et al.  Lattice Boltzmann simulations to determine drag, lift and torque acting on non-spherical particles , 2009 .

[13]  Metin Sitti,et al.  Biomimetic propulsion for a swimming surgical micro-robot , 2003, Proceedings 2003 IEEE/RSJ International Conference on Intelligent Robots and Systems (IROS 2003) (Cat. No.03CH37453).

[14]  A. S. Geller,et al.  Boundary element method calculations of the mobility of nonspherical particles—1. Linear chains , 1993 .

[15]  Ioannis K. Kaliakatsos,et al.  Microrobots for minimally invasive medicine. , 2010, Annual review of biomedical engineering.

[16]  Antoine Ferreira,et al.  Three-Dimensional Controlled Motion of a Microrobot using Magnetic Gradients , 2011, Adv. Robotics.

[17]  Sergej Fatikow,et al.  Evaluation of a MRI based propulsion/control system aiming at targeted micro/nano-capsule therapeutics , 2012, 2012 IEEE/RSJ International Conference on Intelligent Robots and Systems.

[18]  Antoine Ferreira,et al.  Adaptive Controller and Observer for a Magnetic Microrobot , 2013, IEEE Transactions on Robotics.

[19]  R. P. Chhabra,et al.  An experimental study of motion of cylinders in Newtonian fluids: wall effects and drag coefficient , 1991 .

[20]  Derek B. Ingham,et al.  THE STEADY FLOW OF A VISCOUS FLUID DUE TO A ROTATING SPHERE , 1981 .

[21]  Filippov Drag and Torque on Clusters of N Arbitrary Spheres at Low Reynolds Number. , 2000, Journal of colloid and interface science.

[22]  Jake J. Abbott,et al.  How Should Microrobots Swim? , 2009, ISRR.

[23]  M. Zastawny,et al.  Derivation of drag and lift force and torque coefficients for non-spherical particles in flows , 2012 .

[24]  Sylvain Martel,et al.  Flagellated Magnetotactic Bacteria as Controlled MRI-trackable Propulsion and Steering Systems for Medical Nanorobots Operating in the Human Microvasculature , 2009, Int. J. Robotics Res..

[25]  G. Kasper,et al.  Measurements of viscous drag on cylinders and chains of spheres with aspect ratios between 2 and 50 , 1985 .

[26]  Lixin Dong,et al.  Artificial bacterial flagella: Fabrication and magnetic control , 2009 .

[27]  Metin Sitti,et al.  Two-Dimensional Contact and Noncontact Micromanipulation in Liquid Using an Untethered Mobile Magnetic Microrobot , 2009, IEEE Transactions on Robotics.

[28]  Marcus L. Roper,et al.  Microscopic artificial swimmers , 2005, Nature.

[29]  Eric Lauga,et al.  Propulsion by passive filaments and active flagella near boundaries. , 2010, Physical review. E, Statistical, nonlinear, and soft matter physics.

[30]  S. Martel,et al.  Automatic navigation of an untethered device in the artery of a living animal using a conventional clinical magnetic resonance imaging system , 2007 .