Application of a Reagentless Direct Conductivity Online TOC Analyzer for Clean-in-Place Verification

This paper describes a method for automating CIP validation analysis of both conductivity and TOC. This is achieved by integrating a reagentless direct conductivity online TOC analyzer with a modern mobile Cleaningin-Place module for real-time cleaning verification. The ANATEL A643a online TOC analyzer provides both real-time conductivity and real-time TOC results for the CIP unit, providing rapid approval of cleaning processes and subsequent release of the production equipment for manufacturing. The potential cost savings described include material costs, labor costs and reduction in downtime. By integrating online TOC into the CIP system, the pharmaceutical vessel being cleaned can be returned to production more rapidly and efficiently and with greater reliability.