Relationship of body composition and circulatory adiponectin to bone mineral density in young premenopausal women.

OBJECTIVE Adiponectin is a recently discovered hormone secreted by adipocytes. Adiponectin plays an important role in the regulation of insulin sensitivity as well as the propensity to inflammation and atherosclerosis. In the present study, the authors explore the relationship between adiponectin and bone mass in premenopausal women. The relationship of fat mass compared to lean body mass to bone mass was also investigated MATERIAL AND METHOD Two hundred premenopausal women aged between 20 and 40 years were studied. Bone mineral density (BMD) was measured at L2-4 and femoral neck by dual-energy X-ray absorptiometry (DEXA). Serum adiponectin concentrations were measured by radioimmunoassay. RESULTS At the lumbar spines, factors associated with BMD were age (p < 0.01) and lean body mass (p < 0.001). No independent association with fat mass was demonstrated Likewise, at the femoral neck, only lean body mass was related to BMD (p < 0. 01). In terms of the relation of serum adiponectin to BMD, no association of serum adiponectin to BMD at the lumbar spines or femoral neck was found CONCLUSION Altogether, the present findings do not suggest the independent role of adiponectin in the accrual of bone mass in females, although such a role still cannot be excluded in men or postmenopausal women.

[1]  T. Tai,et al.  Lack of independent relationship between plasma adiponectin, leptin levels and bone density in nondiabetic female adolescents , 2004, Clinical endocrinology.

[2]  T. Douchi,et al.  The leptin receptor in human osteoblasts and the direct effect of leptin on bone metabolism , 2004, Gynecological endocrinology : the official journal of the International Society of Gynecological Endocrinology.

[3]  U. Dafni,et al.  Blood Leptin and Adiponectin as Possible Mediators of the Relation Between Fat Mass and BMD in Perimenopausal Women , 2004, Journal of bone and mineral research : the official journal of the American Society for Bone and Mineral Research.

[4]  S. Takeda,et al.  Serum leptin level is a regulator of bone mass. , 2004, Proceedings of the National Academy of Sciences of the United States of America.

[5]  D. Xie,et al.  Leptin deficiency produces contrasting phenotypes in bones of the limb and spine. , 2004, Bone.

[6]  B. Staels,et al.  Expression of adiponectin receptors in human macrophages and regulation by agonists of the nuclear receptors PPARalpha, PPARgamma, and LXR. , 2004, Biochemical and biophysical research communications.

[7]  J. Reginster,et al.  Minimal levels of serum estradiol prevent postmenopausal bone loss , 1992, Calcified Tissue International.

[8]  G. Ning,et al.  Relationship between body composition and bone mineral density in healthy young and premenopausal Chinese women , 2004, Osteoporosis International.

[9]  D. Eizirik,et al.  Expression of adiponectin receptors in pancreatic beta cells. , 2003, Biochemical and biophysical research communications.

[10]  R. Porcher,et al.  Serum leptin as a determinant of bone resorption in healthy postmenopausal women. , 2003, Bone.

[11]  K. Lohman,et al.  Adiponectin as a novel determinant of bone mineral density and visceral fat. , 2003, Bone.

[12]  Philippe Froguel,et al.  Cloning of adiponectin receptors that mediate antidiabetic metabolic effects , 2003, Nature.

[13]  T. Douchi,et al.  Difference in the effects of body composition on bone mineral density between pre- and postmenopausal women. , 2002, Maturitas.

[14]  J. Everhart,et al.  Relationship of Serum Leptin Concentration With Bone Mineral Density in the United States Population , 2002, Journal of bone and mineral research : the official journal of the American Society for Bone and Mineral Research.

[15]  Y. Lee,et al.  Leptin receptor isoform expression in rat osteoblasts and their functional analysis , 2002, FEBS letters.

[16]  L. Melton,et al.  Role of Low Levels of Endogenous Estrogen in Regulation of Bone Resorption in Late Postmenopausal Women , 2002, Journal of bone and mineral research : the official journal of the American Society for Bone and Mineral Research.

[17]  Arndt F Schilling,et al.  Leptin Inhibits Bone Formation through a Hypothalamic Relay A Central Control of Bone Mass , 2000, Cell.

[18]  V M Chinchilli,et al.  Body composition development of adolescent white females: the Penn State Young Women's Health Study. , 1998, Archives of pediatrics & adolescent medicine.