CeleryDB: a genomic database for celery

Abstract Celery (Apium graveolens L.) is a plant belonging to the Apiaceae family, and a popular vegetable worldwide because of its abundant nutrients and various medical functions. Although extensive genetic and molecular biological studies have been conducted on celery, its genomic data remain unclear. Given the significance of celery and the growing demand for its genomic data, the whole genome of ‘Q2-JN11’ celery (a highly inbred line obtained by artificial selfing of ‘Jinnan Shiqin’) was sequenced using HiSeq 2000 sequencing technology. For the convenience of researchers to study celery, an online database of the whole-genome sequences of celery, CeleryDB, was constructed. The sequences of the whole genome, nucleotide sequences of the predicted genes and amino acid sequences of the predicted proteins are available online on CeleryDB. Home, BLAST, Genome Browser, Transcription Factor and Download interfaces composed of the organizational structure of CeleryDB. Users can search the celery genomic data by using two user-friendly query tools: basic local alignment search tool and Genome Browser. In the future, CeleryDB will be constantly updated to satisfy the needs of celery researchers worldwide. Database URL: http://apiaceae.njau.edu.cn/celerydb

[1]  Sean R. Eddy,et al.  Accelerated Profile HMM Searches , 2011, PLoS Comput. Biol..

[2]  Yuko Ohashi,et al.  DNA binding and dimerization specificity and potential targets for the TCP protein family. , 2002, The Plant journal : for cell and molecular biology.

[3]  Ian Korf,et al.  Gene finding in novel genomes , 2004, BMC Bioinformatics.

[4]  Karam B. Singh,et al.  Transcription factors in plant defense and stress responses. , 2002, Current opinion in plant biology.

[5]  Juan Miguel García-Gómez,et al.  BIOINFORMATICS APPLICATIONS NOTE Sequence analysis Manipulation of FASTQ data with Galaxy , 2005 .

[6]  Shoshi Kikuchi,et al.  Genome-wide analysis of NAC transcription factor family in rice. , 2010, Gene.

[7]  P Demoly,et al.  IgE reactivity to Api g 1, a major celery allergen, in a Central European population is based on primary sensitization by Bet v 1. , 1999, The Journal of allergy and clinical immunology.

[8]  Mark Johnson,et al.  NCBI BLAST: a better web interface , 2008, Nucleic Acids Res..

[9]  Richard D. Thompson,et al.  The role of the DNA-binding One Zinc Finger (DOF) transcription factor family in plants. , 2013, Plant science : an international journal of experimental plant biology.

[10]  S. Shukla,et al.  Apigenin-mediated modulations of PI3K-Akt and MAPK signaling pathways causes growth Inhibition and cell cycle arrest in human prostate cancer cells , 2007 .

[11]  Yan Li,et al.  Comparative proteomic analysis provides novel insights into chlorophyll biosynthesis in celery under temperature stress. , 2017, Physiologia plantarum.

[12]  Karin Hoffmann-Sommergruber,et al.  Characterization of Api g 1.0201, a New Member of the Api g 1 Family of Celery Allergens , 2000, International Archives of Allergy and Immunology.

[13]  Jing Ma,et al.  Identification of SSRs and differentially expressed genes in two cultivars of celery (Apium graveolens L.) by deep transcriptome sequencing , 2014, Horticulture Research.

[14]  Jing Ma,et al.  High throughput sequencing of two celery varieties small RNAs identifies microRNAs involved in temperature stress response , 2014, BMC Genomics.

[15]  N. Rajewsky,et al.  The evolution of gene regulation by transcription factors and microRNAs , 2007, Nature Reviews Genetics.

[16]  Hua-Wei Tan,et al.  High-throughput analysis of small RNAs and characterization of novel microRNAs affected by abiotic stress in a local celery cultivar , 2014 .

[17]  M. Ashburner,et al.  Gene Ontology: tool for the unification of biology , 2000, Nature Genetics.

[18]  R. R. Samaha,et al.  Arabidopsis transcription factors: genome-wide comparative analysis among eukaryotes. , 2000, Science.

[19]  Zhi-Sheng Xu,et al.  An R2R3-MYB transcription factor, OjMYB1, functions in anthocyanin biosynthesis in Oenanthe javanica , 2018, Planta.

[20]  S. Rogers,et al.  Extraction of DNA from milligram amounts of fresh, herbarium and mummified plant tissues , 1985, Plant Molecular Biology.

[21]  James Z Zhang,et al.  Overexpression analysis of plant transcription factors. , 2003, Current opinion in plant biology.

[22]  Martin Himly,et al.  Allergenic relevance of nonspecific lipid transfer proteins 2: Identification and characterization of Api g 6 from celery tuber as representative of a novel IgE-binding protein family. , 2013, Molecular nutrition & food research.

[23]  Karin Hoffmann-Sommergruber,et al.  Cross‐reactive N‐glycans of Api g 5, a high molecular weight glycoprotein allergen from celery, are required for immunoglobulin E binding and activation of effector cells from allergic patients , 2003, FASEB journal : official publication of the Federation of American Societies for Experimental Biology.

[24]  B. WüTHRICH Allergieauslösende Nahrungsmittel im Laufe der Zeit eine Statistik der Jahre 1978 1998 , 2005 .

[25]  Jian Wang,et al.  SOAPdenovo2: an empirically improved memory-efficient short-read de novo assembler , 2012, GigaScience.

[26]  K. McNally,et al.  Genomics of gene banks: A case study in rice. , 2012, American journal of botany.

[27]  Burkhard Morgenstern,et al.  AUGUSTUS: ab initio prediction of alternative transcripts , 2006, Nucleic Acids Res..

[28]  Q. Wang,et al.  De Novo Assembly, Gene Annotation and Marker Development Using Illumina Paired-End Transcriptome Sequences in Celery (Apium graveolens L.) , 2013, PloS one.

[29]  F. André,et al.  Role of new allergens and of allergens consumption in the increased incidence of food sensitizations in France. , 1994, Toxicology.

[30]  Alireza Veisi,et al.  The effect of hydro-alcoholic celery (Apiumgraveolens) leaf extract on cardiovascular parameters and lipid profile in animal model of hypertension induced by fructose , 2015, Avicenna journal of phytomedicine.

[31]  Fei Xiong,et al.  De novo assembly, transcriptome characterization, lignin accumulation, and anatomic characteristics: novel insights into lignin biosynthesis during celery leaf development , 2015, Scientific Reports.

[32]  Adriano Mari,et al.  Molecular characterization of Api g 2, a novel allergenic member of the lipid-transfer protein 1 family from celery stalks. , 2011, Molecular nutrition & food research.

[33]  Scheurer,et al.  Cloning of the minor allergen Api g 4 profilin from celery (Apium graveolens) and its cross‐reactivity with birch pollen profilin Bet v 2 , 2000, Clinical and experimental allergy : journal of the British Society for Allergy and Clinical Immunology.

[34]  S. Lewis,et al.  The generic genome browser: a building block for a model organism system database. , 2002, Genome research.

[35]  Rolf Apweiler,et al.  The SWISS-PROT protein sequence database and its supplement TrEMBL in 2000 , 2000, Nucleic Acids Res..

[36]  Ingo Dreyer,et al.  PlnTFDB: an integrative plant transcription factor database , 2007, BMC Bioinformatics.

[37]  Kyung Ho Row,et al.  Determination of luteolin and apigenin in celery using ultrasonic-assisted extraction based on aqueous solution of ionic liquid coupled with HPLC quantification. , 2011, Journal of the science of food and agriculture.

[38]  K. Hoffmann‐Sommergruber,et al.  Molecular characterization of Api g 1, the major allergen of celery (Apium graveolens), and its immunological and structural relationships to a group of 17-kDa tree pollen allergens. , 1995, European journal of biochemistry.

[39]  M. Kopferschmitt‐Kubler,et al.  Celery allergy: clinical and biological study of 20 cases. , 1988, Annals of allergy.

[40]  P. Heuschmann,et al.  Celery allergy confirmed by double-blind, placebo-controlled food challenge: a clinical study in 32 subjects with a history of adverse reactions to celery root. , 2000, The Journal of allergy and clinical immunology.

[41]  Zhi-Sheng Xu,et al.  Advances in the research of celery, an important Apiaceae vegetable crop , 2018, Critical reviews in biotechnology.