MicroRNA‐215‐5p promotes proliferation, invasion, and inhibits apoptosis in liposarcoma cells by targeting MDM2

Liposarcoma (LPS) is one of the most common soft tissue malignancies in adults, and it is characterized by dysregulation of multiple signaling pathways, including MDM2 proto‐oncogene (MDM2) amplification. MicroRNA (miRNA) regulates gene expression through incomplete complementary pairing with the 3' untranslated region of mRNAs involved in tumor progression.

[1]  Xiaoying Lin,et al.  Down-Regulating HAUS6 Suppresses Cell Proliferation by Activating the p53/p21 Pathway in Colorectal Cancer , 2022, Frontiers in Cell and Developmental Biology.

[2]  M. Schmitz,et al.  MEKK1-Dependent Activation of the CRL4 Complex Is Important for DNA Damage-Induced Degradation of p21 and DDB2 and Cell Survival , 2021, Molecular and cellular biology.

[3]  Hua Lu,et al.  Valosin-Containing Protein Stabilizes Mutant p53 to Promote Pancreatic Cancer Growth , 2021, Cancer Research.

[4]  Ismaeel Bin-Jaliah La Quercetina Inhibe el Eje de Apoptosis ROS-p53-Bax-Caspasa-3 y Aumenta la Gonadotropina y las Hormonas Testiculares en la Lesión Testicular Inducida por Estrés Crónico e Impredecible , 2021 .

[5]  Haibing Wang,et al.  Caspase 3/GSDME-dependent pyroptosis contributes to chemotherapy drug-induced nephrotoxicity , 2021, Cell Death & Disease.

[6]  Eun Mi Kim,et al.  p21WAF1/CIP1 promotes p53 protein degradation by facilitating p53-Wip1 and p53-Mdm2 interaction. , 2021, Biochemical and biophysical research communications.

[7]  Zhe Qiao,et al.  LncRNA PCAT1 Interacts with DKC1 to Regulate Proliferation, Invasion and Apoptosis in NSCLC Cells via the VEGF/AKT/Bcl2/Caspase9 Pathway , 2021, Cell transplantation.

[8]  Seon-Hee Oh,et al.  Autophagy-mediated cytoplasmic accumulation of p53 leads to apoptosis through DRAM-BAX in cadmium-exposed human proximal tubular cells. , 2020, Biochemical and biophysical research communications.

[9]  Yongdong Feng,et al.  PIK3R3 inhibits cell senescence through p53/p21 signaling , 2020, Cell Death & Disease.

[10]  Hui Li,et al.  miR-452-5p and miR-215-5p expression levels in colorectal cancer tissues and their relationship with clinicopathological features , 2020, Oncology letters.

[11]  Xinhua Xu,et al.  miR-215 Inhibits Colorectal Cancer Cell Migration and Invasion via Targeting Stearoyl-CoA Desaturase , 2020, Comput. Math. Methods Medicine.

[12]  R. Pollock,et al.  Extracellular vesicle cross-talk in the liposarcoma microenvironment. , 2020, Cancer letters.

[13]  A. Gronchi,et al.  Soft‐tissue sarcoma in adults: An update on the current state of histiotype‐specific management in an era of personalized medicine , 2020, CA: a cancer journal for clinicians.

[14]  Yi-Peng Jiang,et al.  Increasing Incidence of Liposarcoma: A Population-Based Study of National Surveillance Databases, 2001–2016 , 2020, International journal of environmental research and public health.

[15]  A. Beggs,et al.  A review of retroperitoneal liposarcoma genomics. , 2020, Cancer treatment reviews.

[16]  Tianren Huang,et al.  Long noncoding RNA VPS9D1-AS1 augments the malignant phenotype of non-small cell lung cancer by sponging microRNA-532-3p and thereby enhancing HMGA2 expression , 2020, Aging.

[17]  Samayita Das MDM2 Inhibition in a Subset of Sarcoma Cell Lines Increases Susceptibility to Radiation Therapy by Inducing Senescence in the Polyploid Cells , 2019, Advances in radiation oncology.

[18]  P. Leedman,et al.  Modulation of miRNA function by natural and synthetic RNA-binding proteins in cancer , 2019, Cellular and Molecular Life Sciences.

[19]  Min Liu,et al.  GRSF1-mediated MIR-G-1 promotes malignant behavior and nuclear autophagy by directly upregulating TMED5 and LMNB1 in cervical cancer cells , 2019, Autophagy.

[20]  A. Italiano Is There Value in Molecular Profiling of Soft-Tissue Sarcoma? , 2018, Current Treatment Options in Oncology.

[21]  Damian Szklarczyk,et al.  STRING v11: protein–protein association networks with increased coverage, supporting functional discovery in genome-wide experimental datasets , 2018, Nucleic Acids Res..

[22]  Carsten Sticht,et al.  miRWalk: An online resource for prediction of microRNA binding sites , 2018, PloS one.

[23]  H. Chander,et al.  Awakening the “guardian of genome”: reactivation of mutant p53 , 2018, Cancer Chemotherapy and Pharmacology.

[24]  S. Sleijfer,et al.  Soft tissue and visceral sarcomas: ESMO-EURACAN Clinical Practice Guidelines for diagnosis, treatment and follow-up. , 2018, Annals of oncology : official journal of the European Society for Medical Oncology.

[25]  S. Sleijfer,et al.  Differences in recurrence and survival of extremity liposarcoma subtypes. , 2018, European journal of surgical oncology : the journal of the European Society of Surgical Oncology and the British Association of Surgical Oncology.

[26]  Yuehua Wu,et al.  High amplification levels of MDM2 and CDK4 correlate with poor outcome in patients with dedifferentiated liposarcoma: A cytogenomic microarray analysis of 47 cases. , 2017, Cancer genetics.

[27]  Jing Wang,et al.  LinkedOmics: analyzing multi-omics data within and across 32 cancer types , 2017, Nucleic Acids Res..

[28]  Hsien-Da Huang,et al.  miRTarBase update 2018: a resource for experimentally validated microRNA-target interactions , 2017, Nucleic Acids Res..

[29]  Hua Lu,et al.  Reviving the guardian of the genome: Small molecule activators of p53 , 2017, Pharmacology & therapeutics.

[30]  Kunpeng Liu,et al.  miR-215 promotes cell migration and invasion of gastric cancer by targeting Retinoblastoma tumor suppressor gene 1. , 2017, Pathology, research and practice.

[31]  L. Kenner,et al.  When the guardian sleeps: Reactivation of the p53 pathway in cancer. , 2017, Mutation research.

[32]  A. Italiano,et al.  Combined targeting of MDM2 and CDK4 is synergistic in dedifferentiated liposarcomas , 2017, Journal of Hematology & Oncology.

[33]  Xiaofeng Meng,et al.  miR-215 functions as an oncogene in high-grade glioma by regulating retinoblastoma 1 , 2017, Biotechnology Letters.

[34]  J. Schellens,et al.  A phase I study of SAR405838, a novel human double minute 2 (HDM2) antagonist, in patients with solid tumours. , 2017, European journal of cancer.

[35]  Yu-jie Lei,et al.  Expression of PANDA, LincRNA-p21, PUMA in lung tissues of lung cancer patients in the Xuanwei and non-Xuanwei areas of Yunnan Province , 2017 .

[36]  N. Hiraoka,et al.  Primary Retroperitoneal Myxoid Liposarcomas , 2016, The American journal of surgical pathology.

[37]  Yu Wang,et al.  MicroRNAs activate gene transcription epigenetically as an enhancer trigger , 2016, RNA biology.

[38]  L. Shen,et al.  miR-215 promotes malignant progression of gastric cancer by targeting RUNX1 , 2015, Oncotarget.

[39]  Min Liu,et al.  miR-346 and miR-138 competitively regulate hTERT in GRSF1- and AGO2-dependent manners, respectively , 2015, Scientific Reports.

[40]  D. Bartel,et al.  Predicting effective microRNA target sites in mammalian mRNAs , 2015, eLife.

[41]  J. Fletcher,et al.  HDACi inhibits liposarcoma via targeting of the MDM2-p53 signaling axis and PTEN, irrespective of p53 mutational status , 2014, Oncotarget.

[42]  Jean Hausser,et al.  MicroRNA binding sites in the coding region of mRNAs: Extending the repertoire of post‐transcriptional gene regulation , 2014, BioEssays : news and reviews in molecular, cellular and developmental biology.

[43]  R. Eils,et al.  MicroRNA profiling of primary high‐grade soft tissue sarcomas , 2012, Genes, chromosomes & cancer.

[44]  R. Place,et al.  Upregulation of Cyclin B1 by miRNA and its implications in cancer , 2011, Nucleic acids research.

[45]  Ashley P E Roberts,et al.  miR-122 activates hepatitis C virus translation by a specialized mechanism requiring particular RNA components , 2011, Nucleic acids research.

[46]  Brian D Athey,et al.  New class of microRNA targets containing simultaneous 5'-UTR and 3'-UTR interaction sites. , 2009, Genome research.

[47]  H. Grosshans,et al.  Repression of C. elegans microRNA targets at the initiation level of translation requires GW182 proteins , 2009, The EMBO journal.

[48]  Takayuki Murata,et al.  MicroRNA Inhibition of Translation Initiation in Vitro by Targeting the Cap-Binding Complex eIF4F , 2007, Science.

[49]  S. Grewal,et al.  Transcription and RNA interference in the formation of heterochromatin , 2007, Nature.

[50]  E. Finnegan,et al.  The small RNA world , 2003, Journal of Cell Science.

[51]  S. Peltz,et al.  The cap-to-tail guide to mRNA turnover , 2001, Nature Reviews Molecular Cell Biology.

[52]  C. Y. Chen,et al.  AU-rich elements: characterization and importance in mRNA degradation. , 1995, Trends in biochemical sciences.

[53]  OUP accepted manuscript , 2022, Nucleic Acids Research.

[54]  A. Jemal,et al.  Cancer statistics, 2019 , 2019, CA: a cancer journal for clinicians.

[55]  A. Jemal,et al.  Cancer statistics, 2018 , 2018, CA: a cancer journal for clinicians.

[56]  J. Pan,et al.  miR-215 promotes cell migration and invasion of gastric cancer cell lines by targeting FOXO1. , 2017, Neoplasma.

[57]  N. Dubrawsky Cancer statistics , 2022 .