Comparison of the natural history of alcoholic and nonalcoholic fatty liver disease

Fatty liver disease represents a common clinical entity. It is classically divided into alcoholic fatty liver disease (AFLD) and nonalcoholic fatty liver disease (NAFLD). Whereas AFLD occurs in as many as 10 million Americans, NAFLD represents the most common chronic liver disease and is the most common cause of liver enzyme abnormalities in the United States. Both diseases encompass the clinical spectrum of steatosis, steatohepatitis, and cirrhosis. Although they are histologically indistinct, AFLD and NAFLD follow different clinical courses. This article compares the natural history of these diseases.

[1]  S. Caldwell,et al.  Cryptogenic cirrhosis: Clinical characterization and risk factors for underlying disease , 1999, Hepatology.

[2]  J. Neuberger,et al.  Orthotopic liver transplantation for alcoholic liver disease: A retrospective analysis of survival, recidivism, and risk factors predisposing to recidivism , 2001, Liver transplantation : official publication of the American Association for the Study of Liver Diseases and the International Liver Transplantation Society.

[3]  K. Batts,et al.  Frequency of nonalcoholic steatohepatitis as a cause of advanced liver disease , 2001, Liver transplantation : official publication of the American Association for the Study of Liver Diseases and the International Liver Transplantation Society.

[4]  James G Kench,et al.  Long‐term outcomes of cirrhosis in nonalcoholic steatohepatitis compared with hepatitis C , 2003, Hepatology.

[5]  Z. Younossi,et al.  Nonalcoholic fatty liver disease: a spectrum of clinical and pathological severity. , 1999, Gastroenterology.

[6]  K. Batts,et al.  Independent predictors of liver fibrosis in patients with nonalcoholic steatohepatitis , 1999, Hepatology.

[7]  H. Cortez‐Pinto,et al.  Nonalcoholic Steatohepatitis—A Long-Term Follow-Up Study: Comparison with Alcoholic Hepatitis in Ambulatory and Hospitalized Patients , 2003, Digestive Diseases and Sciences.

[8]  G. Corrao,et al.  Are the recent trends in liver cirrhosis mortality affected by the changes in alcohol consumption? Analysis of latency period in European countries. , 1997, Journal of studies on alcohol.

[9]  J. Dixon,et al.  Nonalcoholic fatty liver disease: predictors of nonalcoholic steatohepatitis and liver fibrosis in the severely obese. , 2001, Gastroenterology.

[10]  P. Hayashi,et al.  The natural history of nonalcoholic fatty liver disease: a clinical histopathological study , 2003, American Journal of Gastroenterology.

[11]  M. Bennett,et al.  Determinants of progression to cirrhosis or fibrosis in pure alcoholic fatty liver , 1995, The Lancet.

[12]  W. Kim,et al.  Burden of liver disease in the United States: Summary of a workshop , 2002, Hepatology.

[13]  T. Tosch,et al.  Significance of megamitochondria in alcoholic liver disease. , 1986, Gastroenterology.

[14]  P. Gartside,et al.  Prognostic factors in alcoholic liver disease. VA Cooperative Study Group. , 1991, The American journal of gastroenterology.

[15]  G. Brandi,et al.  Prevalence of and Risk Factors for Hepatic Steatosis in Northern Italy , 2000, Annals of Internal Medicine.

[16]  R. Hanson,et al.  The natural history of nonalcoholic steatohepatitis: A follow‐up study of forty‐two patients for up to 21 years , 1990, Hepatology.

[17]  J. Galambos.  Natural history of alcoholic hepatitis. 3. Histological changes. , 1972, Gastroenterology.

[18]  Mauro Salizzoni,et al.  Expanding the natural history of nonalcoholic steatohepatitis: from cryptogenic cirrhosis to hepatocellular carcinoma. , 2002, Gastroenterology.

[19]  J. Ludwig,et al.  Hepatocellular carcinoma in patients with non-alcoholic steatohepatitis. , 2002, Journal of hepatology.

[20]  J. Maher.  Alcoholic steatosis and steatohepatitis. , 2002, Seminars in gastrointestinal disease.

[21]  R. Fisher,et al.  Development of nonalcoholic fatty liver disease after orthotopic liver transplantation for cryptogenic cirrhosis , 2001, Liver transplantation : official publication of the American Association for the Study of Liver Diseases and the International Liver Transplantation Society.

[22]  B. Neuschwander‐Tetri,et al.  730 NASH: clinical assessment of 501 patients from two separate academic medical centers with validation of a clinical scoring system for advanced hepatic fibrosis , 2003 .

[23]  Randall G. Lee,et al.  Nonalcoholic steatohepatitis: a study of 49 patients. , 1989, Human pathology.

[24]  Christiano Perin,et al.  [The importance of AST / ALT rate in nonalcoholic steatohepatitis diagnosis]. , 2002, Arquivos de gastroenterologia.

[25]  C. Yurdaydın,et al.  Risk Factors for Hepatocellular Carcinoma in Turkey , 2001, Digestive Diseases and Sciences.

[26]  Teruaki Kimura,et al.  Hepatocellular carcinoma with nonalcoholic steatohepatitis , 2004, Journal of Gastroenterology.

[27]  J. Schwimmer,et al.  Nonalcoholic fatty liver disease in the pediatric population. , 2004, Clinics in liver disease.

[28]  P. Bedossa,et al.  Independent risk factors for hepatocellular carcinoma in french drinkers , 1991, Hepatology.

[29]  R. Paraná,et al.  Nonalcoholic steatohepatitis and hepatocellular carcinoma: natural history? , 2000 .

[30]  A. McCullough,et al.  The clinical features, diagnosis and natural history of nonalcoholic fatty liver disease. , 2004, Clinics in liver disease.

[31]  D. V. van Thiel,et al.  Orthotopic liver transplantation for alcoholic cirrhosis. , 1988, JAMA.

[32]  Jeanne M Clark,et al.  Defining nonalcoholic fatty liver disease: implications for epidemiologic studies. , 2003, Gastroenterology.

[33]  J. Caballería,et al.  Histological course of alcoholic hepatitis. Influence of abstinence, sex and extent of hepatic damage. , 1986, Journal of hepatology.

[34]  P. Giral,et al.  Survival, liver failure, and hepatocellular carcinoma in obesity‐related cryptogenic cirrhosis , 2002, Hepatology.

[35]  P. Ward,et al.  Increased hepatic iron concentration in nonalcoholic steatohepatitis is associated with increased fibrosis. , 1998, Gastroenterology.

[36]  P. Giral,et al.  Liver fibrosis in overweight patients. , 2000, Gastroenterology.

[37]  B. Neuschwander‐Tetri,et al.  Nonalcoholic steatohepatitis: an expanded clinical entity. , 1994, Gastroenterology.

[38]  P. Bedossa,et al.  Risk factors of fibrosis in alcohol‐induced liver disease , 2002, Hepatology.

[39]  S. Caldwell,et al.  The spectrum expanded: cryptogenic cirrhosis and the natural history of non-alcoholic fatty liver disease. , 2004, Journal of hepatology.

[40]  J. Marrero,et al.  NAFLD may be a common underlying liver disease in patients with hepatocellular Carcinoma in the United States , 2002, Hepatology.

[41]  N. Chalasani,et al.  Nonalcoholic fatty liver disease in individuals with severe obesity. , 2004, Clinics in liver disease.

[42]  G. Marchesini,et al.  Clinical Features and Natural History of Nonalcoholic Steatosis Syndromes , 2001, Seminars in liver disease.

[43]  I. Wanless,et al.  Fatty liver hepatitis (steatohepatitis) and obesity: An autopsy study with analysis of risk factors , 1990, Hepatology.

[44]  F. Capron,et al.  Excess weight risk factor for alcoholic liver disease , 1997, Hepatology.

[45]  G. Gores,et al.  Pathogenesis, diagnosis, and treatment of alcoholic liver disease. , 2001, Mayo Clinic proceedings.

[46]  M. Weltman,et al.  HFE mutations, hepatic iron, and fibrosis: Ethnic‐specific association of NASH with C282Y but not with fibrotic severity , 2002, Hepatology.

[47]  P. Thuluvath,et al.  Prevalence of obesity and diabetes in patients with cryptogenic cirrhosis: A case‐control study , 2000, Hepatology.

[48]  A. Medline,et al.  Prognosis of alcoholic cirrhosis in the presence and absence of alcoholic hepatitis. , 1987, Gastroenterology.

[49]  T. Morgan,et al.  Epidemiology of Alcoholic Liver Disease , 2004, Seminars in liver disease.

[50]  P. Brissot,et al.  Indication of liver transplantation in severe alcoholic liver cirrhosis: quantitative evaluation and optimal timing. , 2002, Journal of hepatology.

[51]  M. Bennett,et al.  The natural history of nonalcoholic fatty liver: A follow‐up study , 1995, Hepatology.

[52]  W. Vogel,et al.  Prognosis and life expectancy in chronic liver disease , 1995, Digestive Diseases and Sciences.

[53]  A. McCullough,et al.  Alcoholic liver disease: proposed recommendations for the American College of Gastroenterology , 1998, American Journal of Gastroenterology.

[54]  K. Tsuneyama,et al.  Hepatocellular carcinoma arising in non‐alcoholic steatohepatitis , 2001, Pathology international.

[55]  C. Tiribelli,et al.  The spectrum of liver disease in the general population: lesson from the Dionysos study. , 2001, Journal of hepatology.

[56]  J. Everhart,et al.  Epidemiology of nonalcoholic fatty liver. , 2004, Clinics in liver disease.

[57]  S. Borowsky,et al.  Continued heavy drinking and survival in alcoholic cirrhotics , 1981 .