Micellar Nanocarriers: Pharmaceutical Perspectives

[1]  Smadar Cohen,et al.  Microparticulate Systems for the Delivery of Proteins and Vaccines , 2020 .

[2]  G. Kwon,et al.  Polymeric micelles for drug delivery. , 2006, Current pharmaceutical design.

[3]  R. Gurny,et al.  Novel polymeric micelles for hydrophobic drug delivery based on biodegradable poly(hexyl-substituted lactides). , 2006, International journal of pharmaceutics.

[4]  Jia-Ling Yang,et al.  Environmental-sensitive micelles based on poly(2-ethyl-2-oxazoline)-b-poly(L-lactide) diblock copolymer for application in drug delivery. , 2006, International journal of pharmaceutics.

[5]  K. Uhrich,et al.  Novel amphiphilic macromolecules and their in vitro characterization as stabilized micellar drug delivery systems. , 2006, Journal of colloid and interface science.

[6]  Hui Gao,et al.  Conjugates of poly(DL-lactic acid) with ethylenediamino or diethylenetriamino bridged bis(beta-cyclodextrin)s and their nanoparticles as protein delivery systems. , 2006, Journal of controlled release : official journal of the Controlled Release Society.

[7]  M. Brewster,et al.  Intestinal uptake and biodistribution of novel polymeric micelles after oral administration. , 2006, Journal of controlled release : official journal of the Controlled Release Society.

[8]  R. Zhuo,et al.  Self-assembled thermoresponsive micelles of poly(N-isopropylacrylamide-b-methyl methacrylate). , 2006, Biomaterials.

[9]  M. Radosz,et al.  Highly stable core-surface-crosslinked nanoparticles as cisplatin carriers for cancer chemotherapy. , 2006, Colloids and surfaces. B, Biointerfaces.

[10]  Z. Zhiguo,et al.  Self-assembly of an amphiphilic derivative of chitosan and micellar solubilization of puerarin. , 2006, Colloids and surfaces. B, Biointerfaces.

[11]  Sung Wan Kim,et al.  Novel pH sensitive block copolymer micelles for solvent free drug loading. , 2006, Macromolecular bioscience.

[12]  S. Armes,et al.  Phosphorylcholine-based pH-responsive diblock copolymer micelles as drug delivery vehicles: light scattering, electron microscopy, and fluorescence experiments. , 2006, Biomacromolecules.

[13]  T. Okano,et al.  Preparation of camptothecin-loaded polymeric micelles and evaluation of their incorporation and circulation stability. , 2006, International journal of pharmaceutics.

[14]  Daping Quan,et al.  Novel polymer micelles prepared from chitosan grafted hydrophobic palmitoyl groups for drug delivery. , 2006, Molecular pharmaceutics.

[15]  H. Yan,et al.  Potential application of poly(N-isopropylacrylamide) gel containing polymeric micelles to drug delivery systems. , 2005, Colloids and surfaces. B, Biointerfaces.

[16]  V. Torchilin,et al.  Mixed micelles made of poly(ethylene glycol)-phosphatidylethanolamine conjugate and d-alpha-tocopheryl polyethylene glycol 1000 succinate as pharmaceutical nanocarriers for camptothecin. , 2005, International journal of pharmaceutics.

[17]  Marie-Hélène Dufresne,et al.  Block copolymer micelles: preparation, characterization and application in drug delivery. , 2005, Journal of controlled release : official journal of the Controlled Release Society.

[18]  E. K. Park,et al.  Folate-conjugated methoxy poly(ethylene glycol)/poly(epsilon-caprolactone) amphiphilic block copolymeric micelles for tumor-targeted drug delivery. , 2005, Journal of controlled release : official journal of the Controlled Release Society.

[19]  D. Brocks,et al.  Polymeric micelles for the solubilization and delivery of cyclosporine A: pharmacokinetics and biodistribution. , 2005, Biomaterials.

[20]  G. Hsiue,et al.  Polymeric micelles with a pH-responsive structure as intracellular drug carriers. , 2005, Journal of controlled release : official journal of the Controlled Release Society.

[21]  D. Maysinger,et al.  Polycaprolactone-block-poly(ethylene oxide) micelles: a nanodelivery system for 17beta-estradiol. , 2005, Molecular pharmaceutics.

[22]  C. Allen,et al.  Methoxy poly(ethylene glycol)-block-poly(delta-valerolactone) copolymer micelles for formulation of hydrophobic drugs. , 2005, Biomacromolecules.

[23]  N. Nishiyama,et al.  Cisplatin-incorporating polymeric micelles (NC-6004) can reduce nephrotoxicity and neurotoxicity of cisplatin in rats , 2005, British Journal of Cancer.

[24]  N. K. Jain,et al.  Pegylated lysine based copolymeric dendritic micelles for solubilization and delivery of artemether. , 2005, Journal of pharmacy & pharmaceutical sciences : a publication of the Canadian Society for Pharmaceutical Sciences, Societe canadienne des sciences pharmaceutiques.

[25]  A. Exner,et al.  Enhancement of carboplatin toxicity by Pluronic block copolymers. , 2005, Journal of controlled release : official journal of the Controlled Release Society.

[26]  Yi Yan Yang,et al.  Incorporation and in vitro release of doxorubicin in thermally sensitive micelles made from poly(N-isopropylacrylamide-co-N,N-dimethylacrylamide)-b-poly(D,L-lactide-co-glycolide) with varying compositions. , 2005, Biomaterials.

[27]  S. Siegel,et al.  Synthesis and characterization of mPEG-PLA prodrug micelles. , 2005, Biomacromolecules.

[28]  S. Stolnik,et al.  Synthesis of a novel PEG-block-poly(aspartic acid-stat-phenylalanine) copolymer shows potential for formation of a micellar drug carrier. , 2005, International journal of pharmaceutics.

[29]  S. Thayumanavan,et al.  Dendrimeric micelles for controlled drug release and targeted delivery. , 2005, Molecular pharmaceutics.

[30]  A. Lavasanifar,et al.  Micelles of methoxy poly(ethylene oxide)-b-poly(epsilon-caprolactone) as vehicles for the solubilization and controlled delivery of cyclosporine A. , 2005, Journal of controlled release : official journal of the Controlled Release Society.

[31]  Wim E Hennink,et al.  Thermosensitive and biodegradable polymeric micelles for paclitaxel delivery. , 2005, Journal of controlled release : official journal of the Controlled Release Society.

[32]  C. Allen,et al.  Influence of serum protein on polycarbonate-based copolymer micelles as a delivery system for a hydrophobic anti-cancer agent. , 2005, Journal of controlled release : official journal of the Controlled Release Society.

[33]  You Han Bae,et al.  Doxorubicin loaded pH-sensitive polymeric micelles for reversal of resistant MCF-7 tumor. , 2005, Journal of controlled release : official journal of the Controlled Release Society.

[34]  K. Ulbrich,et al.  Polymeric micellar pH-sensitive drug delivery system for doxorubicin. , 2005, Journal of controlled release : official journal of the Controlled Release Society.

[35]  A. Kabanov,et al.  Synthesis and evaluation of a star amphiphilic block copolymer from poly(epsilon-caprolactone) and poly(ethylene glycol) as a potential drug delivery carrier. , 2005, Bioconjugate chemistry.

[36]  X. Langlois,et al.  Self-assembling PEG-p(CL-co-TMC) copolymers for oral delivery of poorly water-soluble drugs: a case study with risperidone. , 2005, Journal of controlled release : official journal of the Controlled Release Society.

[37]  H. Fain,et al.  Controlled and targeted tumor chemotherapy by micellar-encapsulated drug and ultrasound. , 2005, Journal of controlled release : official journal of the Controlled Release Society.

[38]  Yuichi Ohya,et al.  Formation of core-shell type biodegradable polymeric micelles from amphiphilic poly(aspartic acid)-block-polylactide diblock copolymer. , 2005, Biomacromolecules.

[39]  Kinam Park,et al.  Hydrotropic polymer micelle system for delivery of paclitaxel. , 2005, Journal of controlled release : official journal of the Controlled Release Society.

[40]  N. Nishiyama,et al.  Preparation and biological properties of dichloro(1,2-diaminocyclohexane)platinum(II) (DACHPt)-loaded polymeric micelles. , 2005, Journal of controlled release : official journal of the Controlled Release Society.

[41]  G. Kwon,et al.  PEG-phospholipid micelles for the delivery of amphotericin B. , 2005, Journal of controlled release : official journal of the Controlled Release Society.

[42]  T. Park,et al.  In vivo tumor targeting of ODN-PEG-folic acid/PEI polyelectrolyte complex micelles , 2005, Journal of biomaterials science. Polymer edition.

[43]  V. Torchilin,et al.  Polymeric micelles for delivery of poorly soluble drugs: Preparation and anticancer activity in vitro of paclitaxel incorporated into mixed micelles based on poly(ethylene glycol)-lipid conjugate and positively charged lipids , 2005, Journal of drug targeting.

[44]  T. Okano,et al.  Block Copolymer Design for Camptothecin Incorporation into Polymeric Micelles for Passive Tumor Targeting , 2004, Pharmaceutical Research.

[45]  V. Torchilin,et al.  Targeted polymeric micelles for delivery of poorly soluble drugs , 2004, Cellular and Molecular Life Sciences CMLS.

[46]  J. Leroux,et al.  Poly(N-vinylpyrrolidone)-block-poly(D,L-lactide) as a new polymeric solubilizer for hydrophobic anticancer drugs: in vitro and in vivo evaluation. , 2004, Journal of controlled release : official journal of the Controlled Release Society.

[47]  A. Kabanov,et al.  Mixed Polymer Micelles of Amphiphilic and Cationic Copolymers for Delivery of Antisense Oligonucleotides , 2004, Journal of drug targeting.

[48]  D. Selwood,et al.  Anticancer Drug Development: Preclinical Screening, Clinical Trials and Approval , 2004, British Journal of Cancer.

[49]  J. Leroux,et al.  Novel pH-sensitive supramolecular assemblies for oral delivery of poorly water soluble drugs: preparation and characterization. , 2004, Journal of controlled release : official journal of the Controlled Release Society.

[50]  T Morçöl,et al.  Calcium phosphate-PEG-insulin-casein (CAPIC) particles as oral delivery systems for insulin. , 2004, International journal of pharmaceutics.

[51]  J. Leroux,et al.  Preparation and characterization of water-soluble pH-sensitive nanocarriers for drug delivery. , 2004, International journal of pharmaceutics.

[52]  Tae-You Kim,et al.  Phase I and Pharmacokinetic Study of Genexol-PM, a Cremophor-Free, Polymeric Micelle-Formulated Paclitaxel, in Patients with Advanced Malignancies , 2004, Clinical Cancer Research.

[53]  Vladimir P Torchilin,et al.  Micelles from lipid derivatives of water-soluble polymers as delivery systems for poorly soluble drugs. , 2004, Advanced drug delivery reviews.

[54]  A. Schaper,et al.  Core-cross-linked polymeric micelles as paclitaxel carriers. , 2004, Bioconjugate chemistry.

[55]  Vladimir P Torchilin,et al.  Preparation and in vitro synergistic anticancer effect of vitamin K3 and 1,8-diazabicyclo[5,4,0]undec-7-ene in poly(ethylene glycol)-diacyllipid micelles. , 2004, International journal of pharmaceutics.

[56]  Vladimir P Torchilin,et al.  Increased accumulation of PEG-PE micelles in the area of experimental myocardial infarction in rabbits. , 2004, Journal of controlled release : official journal of the Controlled Release Society.

[57]  V. Andrisano,et al.  Micelles Based on Polyvinyl Alcohol Substituted with Oleic Acid for Targeting of Lipophilic Drugs , 2004, Drug delivery.

[58]  R. Gurny,et al.  Cyclosporine A delivery to the eye: a pharmaceutical challenge. , 2003, European journal of pharmaceutics and biopharmaceutics : official journal of Arbeitsgemeinschaft fur Pharmazeutische Verfahrenstechnik e.V.

[59]  S. Armes,et al.  Solubilization and controlled release of a hydrophobic drug using novel micelle-forming ABC triblock copolymers. , 2003, Biomacromolecules.

[60]  A. Kibbe.  Handbook of Pharmaceutical Excipients , 2003 .

[61]  W. Pitt,et al.  Drug delivery in polymeric micelles: from in vitro to in vivo. , 2003, Journal of controlled release : official journal of the Controlled Release Society.

[62]  You Han Bae,et al.  Polymeric micelle for tumor pH and folate-mediated targeting. , 2003, Journal of controlled release : official journal of the Controlled Release Society.

[63]  E. Schacht,et al.  Use of Block Copolymers of Poly(Ortho Esters) and Poly (Ethylene Glycol) Micellar Carriers as Potential Tumour Targeting Systems , 2003, Journal of drug targeting.

[64]  Afsaneh Lavasanifar,et al.  Amphiphilic block copolymers for drug delivery. , 2003, Journal of pharmaceutical sciences.

[65]  J. Leroux,et al.  pH-sensitive unimolecular polymeric micelles: synthesis of a novel drug carrier. , 2003, Bioconjugate chemistry.

[66]  I. Kwon,et al.  Polymeric micelles of poly(2-ethyl-2-oxazoline)-block-poly(ε-caprolactone) copolymer as a carrier for paclitaxel , 2003 .

[67]  T. Park,et al.  New micelle-like polymer aggregates made from PEI-PLGA diblock copolymers: micellar characteristics and cellular uptake. , 2003, Biomaterials.

[68]  Vladimir P. Torchilin,et al.  Immunomicelles: Targeted pharmaceutical carriers for poorly soluble drugs , 2003, Proceedings of the National Academy of Sciences of the United States of America.

[69]  Chi‐Chang Lin,et al.  Stability and Release Performance of a Series of Pegylated Copolymeric Micelles , 2003, Pharmaceutical Research.

[70]  Kazunori Kataoka,et al.  PEGylated Nanoparticles for Biological and Pharmaceutical Applications , 2003 .

[71]  Y. Baba,et al.  Cationic liposome-mediated gene delivery: biophysical study and mechanism of internalization. , 2003, Archives of biochemistry and biophysics.

[72]  I. Rubinstein,et al.  Sterically Stabilized Phospholipid Mixed Micelles: In Vitro Evaluation as a Novel Carrier for Water-Insoluble Drugs , 2003, Pharmaceutical Research.

[73]  V. Torchilin,et al.  PEG-PE/Phosphatidylcholine Mixed Immunomicelles Specifically Deliver Encapsulated Taxol to Tumor Cells of Different Origin and Promote their Efficient Killing , 2003, Journal of drug targeting.

[74]  M. Tatsuka,et al.  Cationic liposomes with plasmid DNA influence cancer metastatic capability. , 2002, Anticancer research.

[75]  Vladimir P. Torchilin,et al.  Polyethylene Glycol-Diacyllipid Micelles Demonstrate Increased Accumulation in Subcutaneous Tumors in Mice , 2002, Pharmaceutical Research.

[76]  Alexander V Kabanov,et al.  Pluronic block copolymers as novel polymer therapeutics for drug and gene delivery. , 2002, Journal of controlled release : official journal of the Controlled Release Society.

[77]  V. Torchilin,et al.  Diacyllipid-Polymer Micelles as Nanocarriers for Poorly Soluble Anticancer Drugs , 2002 .

[78]  T. Park,et al.  Doxorubicin-conjugated biodegradable polymeric micelles having acid-cleavable linkages. , 2002, Journal of controlled release : official journal of the Controlled Release Society.

[79]  M. Bentley,et al.  Chemistry for peptide and protein PEGylation. , 2002, Advanced drug delivery reviews.

[80]  Veronese Fm,et al.  Introduction and overview of peptide and protein pegylation. , 2002 .

[81]  Francesco M Veronese,et al.  Polyethylene glycol-superoxide dismutase, a conjugate in search of exploitation. , 2002, Advanced drug delivery reviews.

[82]  S M Moghimi,et al.  Chemical camouflage of nanospheres with a poorly reactive surface: towards development of stealth and target-specific nanocarriers. , 2002, Biochimica et biophysica acta.

[83]  Vladimir P Torchilin,et al.  PEG-based micelles as carriers of contrast agents for different imaging modalities. , 2002, Advanced drug delivery reviews.

[84]  A. Kabanov,et al.  Pluronic block copolymers: novel functional molecules for gene therapy. , 2002, Advanced drug delivery reviews.

[85]  Kazunori Kataoka,et al.  Block copolymer micelles for delivery of gene and related compounds. , 2002, Advanced drug delivery reviews.

[86]  B. Luppi,et al.  Poly(Vinylalcohol-Co-Vinyloleate) for the Preparation of Micelles Enhancing Retinyl Palmitate Transcutaneous Permeation , 2002, Drug delivery.

[87]  V. Lenaerts,et al.  Optimizing pH-responsive Polymeric Micelles for Drug Delivery in a Cancer Photodynamic Therapy Model , 2002, Journal of drug targeting.

[88]  A M Tsatsakis,et al.  Amphiphilic poly-N-vinylpyrrolidones: synthesis, properties and liposome surface modification. , 2001, Biomaterials.

[89]  D. Shochat,et al.  N-Succinyl-(beta-alanyl-L-leucyl-L-alanyl-L-leucyl)doxorubicin: an extracellularly tumor-activated prodrug devoid of intravenous acute toxicity. , 2001, Journal of medicinal chemistry.

[90]  Y. Nagasaki,et al.  Sugar-installed block copolymer micelles: their preparation and specific interaction with lectin molecules. , 2001, Biomacromolecules.

[91]  P. Couvreur,et al.  PEGylated polycyanoacrylate nanoparticles as vector for drug delivery in prion diseases , 2001, Journal of Neuroscience Methods.

[92]  P. Cullis,et al.  On the mechanism whereby cationic lipids promote intracellular delivery of polynucleic acids , 2001, Gene Therapy.

[93]  H. Maeda,et al.  Mechanism of tumor-targeted delivery of macromolecular drugs, including the EPR effect in solid tumor and clinical overview of the prototype polymeric drug SMANCS. , 2001, Journal of controlled release : official journal of the Controlled Release Society.

[94]  T. Okano,et al.  Development of the polymer micelle carrier system for doxorubicin. , 2001, Journal of controlled release : official journal of the Controlled Release Society.

[95]  J. Liaw,et al.  In vivo gene delivery into ocular tissues by eye drops of poly(ethylene oxide)-poly(propylene oxide)-poly(ethylene oxide) (PEO-PPO-PEO) polymeric micelles , 2001, Gene Therapy.

[96]  Pierre Lemieux,et al.  Block copolymeric biotransport carriers as versatile vehicles for drug delivery , 2001, Expert opinion on investigational drugs.

[97]  V. Torchilin,et al.  Structure and design of polymeric surfactant-based drug delivery systems. , 2001, Journal of controlled release : official journal of the Controlled Release Society.

[98]  V. Torchilin,et al.  p-Nitrophenylcarbonyl-PEG-PE-liposomes: fast and simple attachment of specific ligands, including monoclonal antibodies, to distal ends of PEG chains via p-nitrophenylcarbonyl groups. , 2001, Biochimica et biophysica acta.

[99]  M. Toborek,et al.  Liposome-Mediated High-Efficiency Transfection of Human Endothelial Cells , 2001, Journal of Vascular Research.

[100]  J. Leroux,et al.  Novel Polymeric Micelles Based on the Amphiphilic Diblock Copolymer Poly(N-vinyl-2-pyrrolidone)-block-poly(D,L-lactide) , 2001, Pharmaceutical Research.

[101]  D. K. Majumdar,et al.  Ketorolac entrapped in polymeric micelles: preparation, characterisation and ocular anti-inflammatory studies. , 2000, International journal of pharmaceutics.

[102]  C. Lipinski.  Drug-like properties and the causes of poor solubility and poor permeability. , 2000, Journal of pharmacological and toxicological methods.

[103]  H. Maeda,et al.  Tumor vascular permeability and the EPR effect in macromolecular therapeutics: a review. , 2000, Journal of controlled release : official journal of the Controlled Release Society.

[104]  K. Ulbrich,et al.  Decreased Binding to Proteins and Cells of Polymeric Gene Delivery Vectors Surface Modified with a Multivalent Hydrophilic Polymer and Retargeting through Attachment of Transferrin* , 2000, The Journal of Biological Chemistry.

[105]  D. Maysinger,et al.  Polycaprolactone-b-poly(ethylene oxide) copolymer micelles as a delivery vehicle for dihydrotestosterone. , 2000, Journal of controlled release : official journal of the Controlled Release Society.

[106]  P. Constantinides,et al.  Formulation Development and Antitumor Activity of a Filter-Sterilizable Emulsion of Paclitaxel , 2000, Pharmaceutical Research.

[107]  D. Voinovich,et al.  Formulation and Evaluation of Vinylpyrrolidone/Vinylacetate Copolymer Microspheres with Carbamazepine , 2000, Pharmaceutical development and technology.

[108]  C. Leamon,et al.  Folate copolymer-mediated transfection of cultured cells. , 1999, Bioconjugate chemistry.

[109]  T. Okano,et al.  Thermo-responsive drug delivery from polymeric micelles constructed using block copolymers of poly(N-isopropylacrylamide) and poly(butylmethacrylate). , 1999, Journal of controlled release : official journal of the Controlled Release Society.

[110]  Christine Allen,et al.  Nano-engineering block copolymer aggregates for drug delivery , 1999 .

[111]  A. Kabanov,et al.  Polyion complex micelles with protein-modified corona for receptor-mediated delivery of oligonucleotides into cells. , 1999, Bioconjugate chemistry.

[112]  M. Jones,et al.  Polymeric micelles - a new generation of colloidal drug carriers. , 1999, European journal of pharmaceutics and biopharmaceutics : official journal of Arbeitsgemeinschaft fur Pharmazeutische Verfahrenstechnik e.V.

[113]  R K Jain,et al.  Augmentation of transvascular transport of macromolecules and nanoparticles in tumors using vascular endothelial growth factor. , 1999, Cancer research.

[114]  Teruo Okano,et al.  Soluble Self-Assembled Block Copolymers for Drug Delivery , 1999, Pharmaceutical Research.

[115]  M. Ogris,et al.  PEGylated DNA/transferrin–PEI complexes: reduced interaction with blood components, extended circulation in blood and potential for systemic gene delivery , 1999, Gene Therapy.

[116]  T. Okano,et al.  Reduction of the Side Effects of an Antitumor Agent, KRN5500, by Incorporation of the Drug into Polymeric Micelles , 1999, Japanese journal of cancer research : Gann.

[117]  T. Okano,et al.  Incorporation of water-insoluble anticancer drug into polymeric micelles and control of their particle size. , 1998, Journal of controlled release : official journal of the Controlled Release Society.

[118]  T. Okano,et al.  Preparation and characterization of thermally responsive block copolymer micelles comprising poly(N-isopropylacrylamide-b-DL-lactide). , 1998, Journal of controlled release : official journal of the Controlled Release Society.

[119]  Vladimir P. Torchilin,et al.  Accumulation of Protein-Loaded Long-Circulating Micelles and Liposomes in Subcutaneous Lewis Lung Carcinoma in Mice , 1998, Pharmaceutical Research.

[120]  D. Maysinger,et al.  Polycaprolactone-b-poly(ethylene oxide) block copolymer micelles as a novel drug delivery vehicle for neurotrophic agents FK506 and L-685,818. , 1998, Bioconjugate chemistry.

[121]  W. Mattice,et al.  Large internal structures of micelles of triblock copolymers with small insoluble molecules in their cores , 1998 .

[122]  R. Ni,et al.  Cell Growth Inhibition by a Novel Vitamin K Is Associated with Induction of Protein Tyrosine Phosphorylation* , 1998, The Journal of Biological Chemistry.

[123]  R. Jain,et al.  Regulation of transport pathways in tumor vessels: role of tumor type and microenvironment. , 1998, Proceedings of the National Academy of Sciences of the United States of America.

[124]  A. Kabanov,et al.  Interpolyelectrolyte and block ionomer complexes for gene delivery: physico-chemical aspects. , 1998, Advanced drug delivery reviews.

[125]  Y. M. Lee,et al.  Clonazepam release from core-shell type nanoparticles in vitro. , 1998, Journal of controlled release : official journal of the Controlled Release Society.

[126]  A S Hoffman,et al.  An AB block copolymer of oligo(methyl methacrylate) and poly(acrylic acid) for micellar delivery of hydrophobic drugs. , 1998, Journal of controlled release : official journal of the Controlled Release Society.

[127]  K. Kataoka,et al.  Remarkable increase in nuclease resistance of plasmid DNA through supramolecular assembly with poly(ethylene glycol)-poly(L-lysine) block copolymer. , 1998, Journal of pharmaceutical sciences.

[128]  K. Kataoka,et al.  Novel polyion complex micelles entrapping enzyme molecules in the core: Preparation of narrowly-distributed micelles from lysozyme and poly(ethylene glycol)-poly(aspartic acid) block copolymer in aqueous medium , 1998 .

[129]  Chong-Su Cho,et al.  METHOXY POLY(ETHYLENE GLYCOL) AND CAPROLACTONE AMPHIPHILIC BLOCK CO POLYMERIC MICELLE CONTAINING INDOMETHACIN. II: MICELLE FORMATION AND DRUG RELEASE BEHAVIORS , 1998 .

[130]  T. Okano,et al.  Characterization of physical entrapment and chemical conjugation of adriamycin in polymeric micelles and their design for in vivo delivery to a solid tumor. , 1998, Journal of controlled release : official journal of the Controlled Release Society.

[131]  Olivier Meyer,et al.  Copolymers of N‐isopropylacrylamide can trigger pH sensitivity to stable liposomes , 1998, FEBS letters.

[132]  Teruo Okano,et al.  Thermo-responsive polymer nanoparticles with a core-shell micelle structure as site-specific drug carriers , 1997 .

[133]  Teruo Okano,et al.  Block copolymer micelles for drug delivery: Loading and release of doxorubicin , 1997 .

[134]  A. Kabanov,et al.  Interactions of pluronic block copolymers with brain microvessel endothelial cells: evidence of two potential pathways for drug absorption. , 1997, Bioconjugate chemistry.

[135]  H. Burt,et al.  Human plasma distribution of free paclitaxel and paclitaxel associated with diblock copolymers. , 1997, Journal of pharmaceutical sciences.

[136]  M. Bally,et al.  Accumulation of liposomal lipid and encapsulated doxorubicin in murine Lewis lung carcinoma: the lack of beneficial effects by coating liposomes with poly(ethylene glycol). , 1997, The Journal of pharmacology and experimental therapeutics.

[137]  Rakesh K. Jain,et al.  Interstitial pH and pO2 gradients in solid tumors in vivo: High-resolution measurements reveal a lack of correlation , 1997, Nature Medicine.

[138]  A. Kabanov,et al.  Anthracycline antibiotics non-covalently incorporated into the block copolymer micelles: in vivo evaluation of anti-cancer activity. , 1996, British Journal of Cancer.

[139]  Teruo Okano,et al.  Polymeric micelles as new drug carriers , 1996 .

[140]  C. Kensil,et al.  Structure-function relationship among Quillaja saponins serving as excipients for nasal and ocular delivery of insulin. , 1996, Journal of pharmaceutical sciences.

[141]  Stephen E. Harding,et al.  Polylactide−Poly(ethylene glycol) Copolymers as Drug Delivery Systems. 1. Characterization of Water Dispersible Micelle-Forming Systems , 1996 .

[142]  V. Torchilin,et al.  Stable polymeric micelles: lymphangiographic contrast media for gamma scintigraphy and magnetic resonance imaging. , 1996, Academic radiology.

[143]  R B Greenwald,et al.  Drug delivery systems: water soluble taxol 2'-poly(ethylene glycol) ester prodrugs-design and in vivo effectiveness. , 1996, Journal of medicinal chemistry.

[144]  S. V. Vinogradov,et al.  Water-soluble block polycations as carriers for oligonucleotide delivery. , 1995, Bioconjugate chemistry.

[145]  F. Starr,et al.  Magnetic resonance imaging of the hepatobiliary system: intestinal absorption studies of manganese mesoporphyrin. , 1995, Academic radiology.

[146]  A. Gabizon,et al.  Liposome circulation time and tumor targeting: implications for cancer chemotherapy , 1995 .

[147]  P. Caliceti,et al.  New synthetic amphiphilic polymers for steric protection of liposomes in vivo. , 1995, Journal of pharmaceutical sciences.

[148]  R. Müller,et al.  The controlled intravenous delivery of drugs using PEG-coated sterically stabilized nanospheres. , 1995, Advanced drug delivery reviews.

[149]  R K Jain,et al.  Vascular permeability in a human tumor xenograft: molecular size dependence and cutoff size. , 1995, Cancer research.

[150]  Vladimir P. Torchilin,et al.  Use of polyoxyethylene-lipid conjugates as long-circulating carriers for delivery of therapeutic and diagnostic agents , 1995 .

[151]  V. Torchilin,et al.  Which polymers can make nanoparticulate drug carriers long-circulating? , 1995 .

[152]  Kazunori Kataoka,et al.  Block copolymer micelles as long-circulating drug vehicles , 1995 .

[153]  Lifeng Zhang,et al.  Multiple Morphologies of "Crew-Cut" Aggregates of Polystyrene-b-poly(acrylic acid) Block Copolymers , 1995, Science.

[154]  Alexander V. Kabanov,et al.  Micelle formation and solubilization of fluorescent probes in poly(oxyethylene-b-oxypropylene-b-oxyethylene) solutions , 1995 .

[155]  Teruo Okano,et al.  Physical Entrapment of Adriamycin in AB Block Copolymer Micelles , 1995, Pharmaceutical Research.

[156]  T. Okano,et al.  Improved synthesis of adriamycin-conjugated poly (ethylene oxide)-poly (aspartic acid) block copolymer and formation of unimodal micellar structure with controlled amount of physically entrapped adriamycin , 1994 .

[157]  V. Torchilin,et al.  Amphiphilic vinyl polymers effectively prolong liposome circulation time in vivo. , 1994, Biochimica et biophysica acta.

[158]  R. Jain,et al.  Microvascular permeability and interstitial penetration of sterically stabilized (stealth) liposomes in a human tumor xenograft. , 1994, Cancer research.

[159]  R. Seifert,et al.  Lipophilic beta-adrenoceptor antagonists and local anesthetics are effective direct activators of G-proteins. , 1994, Biochemical pharmacology.

[160]  J. Pezzuto,et al.  A Mixed Micellar Formulation Suitable for the Parenteral Administration of Taxol , 1994, Pharmaceutical Research.

[161]  Teruo Okano,et al.  Enhanced tumor accumulation and prolonged circulation times of micelle-forming poly(ethylene oxide-aspartate) block copolymer-Adriamycin conjugates , 1994 .

[162]  R. Kumar,et al.  Enhanced gene delivery and mechanism studies with a novel series of cationic lipid formulations. , 1994, The Journal of biological chemistry.

[163]  A. Eisenberg,et al.  A model of micellization for block copolymers in solutions , 1993 .

[164]  G. Schuhmann-Giampieri,et al.  Characterization of Iopromide Liposomes , 1993, Investigative radiology.

[165]  Yokoyama Masayuki,et al.  Block copolymer micelles as vehicles for drug delivery , 1993 .

[166]  T. Okano,et al.  Micelles based on AB block copolymers of poly(ethylene oxide) and poly(.beta.-benzyl L-aspartate) , 1993 .

[167]  T. Okano,et al.  Biodistribution of Micelle-Forming Polymer–Drug Conjugates , 1993, Pharmaceutical Research.

[168]  Alexander V. Kabanov,et al.  A new class of drug carriers: micelles of poly(oxyethylene)-poly(oxypropylene) block copolymers as microcontainers for drug targeting from blood in brain☆ , 1992 .

[169]  J. Anderson,et al.  Biocompatibility studies on plasma polymerized interface materials encompassing both hydrophobic and hydrophilic surfaces. , 1992, Journal of biomedical materials research.

[170]  V. Slepnev,et al.  Micelles of poly(oxyethylene)-poly(oxypropylene) block copolymer (pluronic) as a tool for low-molecular compound delivery into a cell: phosphorylation of intracellular proteins with micelle incorporated [gamma-32P]ATP. , 1992, Biochemistry international.

[171]  D. Lasič.  Mixed micelles in drug delivery , 1992, Nature.

[172]  V. Chekhonin,et al.  Fatty acid acylated Fab-fragments of antibodies to neurospecific proteins as carriers for neuroleptic targeted delivery in brain , 1991, Journal of Neuroimmunology.

[173]  Kazuo Maruyama,et al.  Amphipathic polyethyleneglycols effectively prolong the circulation time of liposomes , 1990, FEBS letters.

[174]  E. Nakashima,et al.  Relationships in the Structure–Tissue Distribution of Basic Drugs in the Rabbit , 1990, Pharmaceutical Research.

[175]  N. G. Popovich,et al.  Pharmaceutical Dosage Forms and Drug Delivery Systems , 1990 .

[176]  T. Okano,et al.  Characterization and anticancer activity of the micelle-forming polymeric anticancer drug adriamycin-conjugated poly(ethylene glycol)-poly(aspartic acid) block copolymer. , 1990, Cancer research.

[177]  N. Melik-Nubarov,et al.  The neuroleptic activity of haloperidol increases after its solubilization in surfactant micelles , 1989, FEBS letters.

[178]  R. Nagarajan,et al.  Block Copolymer Self-Assembly in Selective Solvents: Theory of Solubilization in Spherical Micelles , 1989 .

[179]  I. Tannock,et al.  Acid pH in tumors and its potential for therapeutic exploitation. , 1989, Cancer research.

[180]  S. Karlik,et al.  A liposomal MRI contrast agent: Phosphatid ylethanolamine‐DTPA , 1989, Magnetic resonance in medicine.

[181]  K. Hubner,et al.  Gadolinium‐labeled liposomes containing paramagnetic amphipathic agents: Targeted MRI contrast agents for the liver , 1988, Magnetic resonance in medicine.

[182]  S. Lin,et al.  Pluronic surfactants affecting diazepam solubility, compatibility, and adsorption from i.v. admixture solutions. , 1987, Journal of parenteral science and technology : a publication of the Parenteral Drug Association.

[183]  R. J. Hunter.  Foundations of Colloid Science , 1987 .

[184]  S. Lin,et al.  The influence of three poly(oxyethylene)poly(oxypropylene) surface-active block copolymers on the solubility behavior of indomethacin. , 1986, Pharmaceutica acta Helvetiae.

[185]  J. Nixon,et al.  The effect of sodium lauryl sulphate, cetrimide and polysorbate 20 surfactants on complex coacervate volume and droplet size , 1985, The Journal of pharmacy and pharmacology.

[186]  T. N. Palmer,et al.  The mechanism of liposome accumulation in infarction. , 1984, Biochimica et biophysica acta.

[187]  F. Davis,et al.  Treatment of L5178Y tumor-bearing BDF1 mice with a nonimmunogenic L-glutaminase-L-asparaginase. , 1979, Cancer treatment reports.

[188]  C. Tanford,et al.  The critical micelle concentration of L- -dipalmitoylphosphatidylcholine in water and water-methanol solutions. , 1972, Journal of molecular biology.

[189]  Kazunori Kataoka,et al.  Preparation and biological characterization of polymeric micelle drug carriers with intracellular pH-triggered drug release property: tumor permeability, controlled subcellular drug distribution, and enhanced in vivo antitumor efficacy. , 2005, Bioconjugate chemistry.

[190]  M. Barch,et al.  Polymeric Micelles Based on Amphiphilic Scorpion-like Macromolecules: Novel Carriers for Water-Insoluble Drugs , 2004, Pharmaceutical Research.

[191]  M. N. Sibataa,et al.  Photophysicals and photochemicals studies of zinc ( II ) phthalocyanine in long time circulation micelles for Photodynamic Therapy use , 2004 .

[192]  G. Kwon,et al.  Polymeric micelles for delivery of poorly water-soluble compounds. , 2003, Critical reviews in therapeutic drug carrier systems.

[193]  K. Kataoka,et al.  Lactose-installed poly(ethylene glycol)-poly(d,l-lactide) block copolymer micelles exhibit fast-rate binding and high affinity toward a protein bed simulating a cell surface. A surface plasmon resonance study. , 2003, Bioconjugate chemistry.

[194]  Kazunori Kataoka,et al.  PEGylated nanoparticles for biological and pharmaceutical applications. , 2003, Advanced drug delivery reviews.

[195]  Hesson Chung,et al.  Polymeric micelles of poly(2-ethyl-2-oxazoline)-block-poly(epsilon-caprolactone) copolymer as a carrier for paclitaxel. , 2003, Journal of controlled release : official journal of the Controlled Release Society.

[196]  F. Veronese,et al.  Introduction and overview of peptide and protein pegylation. , 2002, Advanced drug delivery reviews.

[197]  J. M. Harris,et al.  Pegylation: a novel process for modifying pharmacokinetics. , 2001, Clinical pharmacokinetics.

[198]  F. Lombardo,et al.  Experimental and computational approaches to estimate solubility and permeability in drug discovery and development settings. , 2001, Advanced drug delivery reviews.

[199]  P. Low,et al.  Folate-mediated targeting: from diagnostics to drug and gene delivery. , 2001, Drug discovery today.

[200]  R K Jain,et al.  Transport of molecules, particles, and cells in solid tumors. , 1999, Annual review of biomedical engineering.

[201]  V. Torchilin,et al.  CT visualization of blood pool in rats by using long-circulating, iodine-containing micelles. , 1999, Academic radiology.

[202]  T. Okano,et al.  Selective delivery of adriamycin to a solid tumor using a polymeric micelle carrier system. , 1999, Journal of drug targeting.

[203]  G. Kwon,et al.  Diblock copolymer nanoparticles for drug delivery. , 1998, Critical reviews in therapeutic drug carrier systems.

[204]  V. Torchilin.  Polymer-coated long-circulating microparticulate pharmaceuticals. , 1998, Journal of microencapsulation.

[205]  D. Papahadjopoulos,et al.  Medical applications of liposomes , 1998 .

[206]  G. Gazelle,et al.  Block-copolymer of polyethylene glycol and polylysine as a carrier of organic iodine: design of long-circulating particulate contrast medium for X-ray computed tomography. , 1997, Journal of drug targeting.

[207]  B. Teicher,et al.  Anticancer Drug Development Guide , 1997, Cancer Drug Discovery and Development.

[208]  C. Marques.  Bunchy Micelles , 1997 .

[209]  V. Torchilin,et al.  A novel class of antitumor antibodies: nucleosome-restricted antinuclear autoantibodies (ANA) from healthy aged nonautoimmune mice. , 1997, Oncology research.

[210]  Torchilin Vp,et al.  A novel class of antitumor antibodies: nucleosome-restricted antinuclear autoantibodies (ANA) from healthy aged nonautoimmune mice. , 1997, Oncology research.

[211]  V. Torchilin,et al.  Polyethyleneglycol based micelles as carriers of therapeutic and diagnostic agents , 1996 .

[212]  A. Maitra,et al.  Novel Taxol formulation: polyvinylpyrrolidone nanoparticle-encapsulated Taxol for drug delivery in cancer therapy. , 1996, Oncology research.

[213]  Teruo Okano,et al.  Preparation and Characterization of the Micelle-Forming Polymeric Drug Indomethacin-lncorporated Polyfethylene oxide)-Poly(β-benzyl L-aspartate) Block Copolymer Micelles , 1996 .

[214]  P Leander,et al.  A new liposomal contrast medium for CT of the liver. An imaging study in a rabbit tumour model. , 1996, Acta radiologica.

[215]  V. Torchilin.  Handbook of targeted delivery of imaging agents , 1995 .

[216]  V. Torchilin,et al.  NEW APPROACHES IN THE CHEMICAL DESIGN OF Gd- CONTAINING LIPOSOMES FOR USE IN MAGNETIC RESONANCE IMAGING OF LYMPH NODES , 1994 .

[217]  N. Wilke,et al.  Liposomal mr contrast agents , 1994 .

[218]  Raymond C Rowe,et al.  Handbook of Pharmaceutical Excipients , 1994 .

[219]  D. Sahn,et al.  Gas fIIIed lipid bilayers as imaging contrast agents , 1994 .

[220]  R. Müller.  Colloidal Carriers for Controlled Drug Delivery and Targeting: Modification, Characterization, and In Vivo Distribution , 1991 .

[221]  S. Yalkowsky.  Techniques of solubilization of drugs , 1981 .

[222]  M. J. Rosen.  Surfactants and Interfacial Phenomena , 1978 .