Vitamin D 3 attenuates Th 2 responses to Aspergillus fumigatus mounted by CD 4 + T cells from cystic fibrosis patients with allergic bronchopulmonary aspergillosis

1Children’s Hospital of Pittsburgh, Pittsburgh, Pennsylvania, USA. 2University of Alabama at Birmingham Division of Pulmonary, Allergy & Critical Care, Birmingham, Alabama, USA. 3Department of Genetics, Louisiana State University Health Sciences Center (LSUHSC), New Orleans, Louisiana, USA. 4Division of Pulmonary, Allergy and Critical Care Medicine, University of Pittsburgh, Pittsburgh, Pennsylvania, USA. 5Benaroya Research Institute at Virginia Mason, Seattle, Washington, USA. 6Department of Biostatistics, Graduate School of Public Health, University of Pittsburgh, Pittsburgh, Pennsylvania, USA.

[1]  James R Murphy,et al.  Decreased serum vitamin D levels in children with asthma are associated with increased corticosteroid use. , 2010, The Journal of allergy and clinical immunology.

[2]  A. Ray,et al.  Regulatory T Cells in Many Flavors Control Asthma , 2010, Mucosal Immunology.

[3]  J. Skripak.  Chromosome 17q21 Gene Variants Are Associated With Asthma and Exacerbations But Not Atopy in Early Childhood , 2009, Pediatrics.

[4]  E. Matsui,et al.  TH17 Cells Mediate Steroid-Resistant Airway Inflammation and Airway Hyperresponsiveness in Mice , 2009, Pediatrics.

[5]  John H. White,et al.  Asthma and genes encoding components of the vitamin D pathway , 2009, Respiratory research.

[6]  L. Delhaes,et al.  Occurrence and relevance of filamentous fungi in respiratory secretions of patients with cystic fibrosis--a review. , 2009, Medical mycology.

[7]  C. Hawrylowicz,et al.  Vitamin D and asthma: time for intervention? , 2009, American journal of respiratory and critical care medicine.

[8]  E. Hickman,et al.  Ligation of TLR9 induced on human IL-10-secreting Tregs by 1alpha,25-dihydroxyvitamin D3 abrogates regulatory function. , 2009, The Journal of clinical investigation.

[9]  V. Lagishetty,et al.  Vitamin D deficiency modulates Graves' hyperthyroidism induced in BALB/c mice by thyrotropin receptor immunization. , 2009, Endocrinology.

[10]  T. So,et al.  Antagonism of Airway Tolerance by Endotoxin/Lipopolysaccharide through Promoting OX40L and Suppressing Antigen-Specific Foxp3+ T Regulatory Cells1 , 2008, The Journal of Immunology.

[11]  S. Ziegler,et al.  Reversal of Thymic Stromal Lymphopoietin-Induced Airway Inflammation through Inhibition of Th2 Responses1 , 2008, The Journal of Immunology.

[12]  K. Carson,et al.  Current treatment recommendations for correcting vitamin D deficiency in pediatric patients with cystic fibrosis are inadequate. , 2008, The Journal of pediatrics.

[13]  M. Fei,et al.  IL-22 mediates mucosal host defense against Gram-negative bacterial pneumonia , 2008, Nature Medicine.

[14]  H. Hammad,et al.  Dendritic cells and epithelial cells: linking innate and adaptive immunity in asthma , 2008, Nature Reviews Immunology.

[15]  A. Litonjua,et al.  Is vitamin D deficiency to blame for the asthma epidemic? , 2007, The Journal of allergy and clinical immunology.

[16]  Yong‐jun Liu,et al.  IL-25 augments type 2 immune responses by enhancing the expansion and functions of TSLP-DC–activated Th2 memory cells , 2007, The Journal of experimental medicine.

[17]  P. Avila,et al.  TLR3- and Th2 Cytokine-Dependent Production of Thymic Stromal Lymphopoietin in Human Airway Epithelial Cells1 , 2007, The Journal of Immunology.

[18]  R. Duerr.  Genome-wide association studies herald a new era of rapid discoveries in inflammatory bowel disease research. , 2007, Gastroenterology.

[19]  Tomoki Ito,et al.  TSLP: an epithelial cell cytokine that regulates T cell differentiation by conditioning dendritic cell maturation. , 2007, Annual review of immunology.

[20]  C. Eun.  A Genome-Wide Association Study Identifies IL23R as an Inflammatory Bowel Disease Gene. , 2007 .

[21]  S. Ziegler,et al.  Thymic stromal lymphopoietin in normal and pathogenic T cell development and function , 2006, Nature Immunology.

[22]  A. Ray,et al.  Treg-mediated immunosuppression involves activation of the Notch-HES1 axis by membrane-bound TGF-beta. , 2006, The Journal of clinical investigation.

[23]  P. Puccetti,et al.  Immunity and Tolerance to Aspergillus Involve Functionally Distinct Regulatory T Cells and Tryptophan Catabolism1 , 2006, The Journal of Immunology.

[24]  M. Dallman,et al.  Reversing the defective induction of IL-10-secreting regulatory T cells in glucocorticoid-resistant asthma patients. , 2005, The Journal of clinical investigation.

[25]  S. Gordon,et al.  The Beta-Glucan Receptor Dectin-1 Recognizes Specific Morphologies of Aspergillus fumigatus , 2005, PLoS pathogens.

[26]  R. Kumar,et al.  Regulation of relB in dendritic cells by means of modulated association of vitamin D receptor and histone deacetylase 3 with the promoter. , 2005, Proceedings of the National Academy of Sciences of the United States of America.

[27]  H. D. Liggitt,et al.  Thymic stromal lymphopoietin as a key initiator of allergic airway inflammation in mice , 2005, Nature Immunology.

[28]  R. Moss.  Pathophysiology and immunology of allergic bronchopulmonary aspergillosis. , 2005, Medical mycology.

[29]  A. August,et al.  Vitamin D Receptor-Deficient Mice Fail to Develop Experimental Allergic Asthma1 , 2004, The Journal of Immunology.

[30]  R. Boucher,et al.  New concepts of the pathogenesis of cystic fibrosis lung disease , 2004, European Respiratory Journal.

[31]  B. Ameredes,et al.  Tolerance induced by inhaled antigen involves CD4(+) T cells expressing membrane-bound TGF-beta and FOXP3. , 2004, The Journal of clinical investigation.

[32]  S. Donaldson,et al.  Update on pathogenesis of cystic fibrosis lung disease , 2003, Current opinion in pulmonary medicine.

[33]  Michael Light,et al.  Allergic bronchopulmonary aspergillosis in cystic fibrosis--state of the art: Cystic Fibrosis Foundation Consensus Conference. , 2003, Clinical infectious diseases : an official publication of the Infectious Diseases Society of America.

[34]  M. Croft,et al.  OX40 (CD134) Controls Memory T Helper 2 Cells that Drive Lung Inflammation , 2003, The Journal of experimental medicine.

[35]  David F. Richards,et al.  In Vitro Generation of Interleukin 10–producing Regulatory CD4+ T Cells Is Induced by Immunosuppressive Drugs and Inhibited by T Helper Type 1 (Th1)– and Th2-inducing Cytokines , 2002, The Journal of experimental medicine.

[36]  R. Kumar,et al.  Dendritic cell modulation by 1α,25 dihydroxyvitamin D3 and its analogs: A vitamin D receptor-dependent pathway that promotes a persistent state of immaturity in vitro and in vivo , 2001, Proceedings of the National Academy of Sciences of the United States of America.

[37]  E. Spitznagel,et al.  Evidence for the involvement of two different MHC class II regions in susceptibility or protection in allergic bronchopulmonary aspergillosis. , 2000, The Journal of allergy and clinical immunology.

[38]  L. Adorini,et al.  1 Alpha,25-dihydroxyvitamin D3 inhibits differentiation, maturation, activation, and survival of dendritic cells leading to impaired alloreactive T cell activation. , 2000, Journal of immunology.

[39]  D. Kirschmann,et al.  The association of HLA-DR alleles and T cell activation with allergic bronchopulmonary aspergillosis. , 1997, Journal of immunology.

[40]  J. Oak,et al.  Allergic bronchopulmonary aspergillosis. , 1996, Journal of postgraduate medicine.

[41]  P. Heymann,et al.  Development of immune responses to Aspergillus at an early age in children with cystic fibrosis. , 1994, American journal of respiratory and critical care medicine.