Peroxiredoxin-5 Knockdown Accelerates Pressure Overload-Induced Cardiac Hypertrophy in Mice

A recent study showed that peroxiredoxins (Prxs) play an important role in the development of pathological cardiac hypertrophy. However, the involvement of Prx5 in cardiac hypertrophy remains unclear. Therefore, this study is aimed at investigating the role and mechanisms of Prx5 in pathological cardiac hypertrophy and dysfunction. Transverse aortic constriction (TAC) surgery was performed to establish a pressure overload-induced cardiac hypertrophy model. In this study, we found that Prx5 expression was upregulated in hypertrophic hearts and cardiomyocytes. In addition, Prx5 knockdown accelerated pressure overload-induced cardiac hypertrophy and dysfunction in mice by activating oxidative stress and cardiomyocyte apoptosis. Importantly, heart deterioration caused by Prx5 knockdown was related to mitogen-activated protein kinase (MAPK) pathway activation. These findings suggest that Prx5 could be a novel target for treating cardiac hypertrophy and heart failure.

[1]  Y. Kamisah,et al.  Parkia speciosa Hassk. Empty Pod Extract Alleviates Angiotensin II-Induced Cardiomyocyte Hypertrophy in H9c2 Cells by Modulating the Ang II/ROS/NO Axis and MAPK Pathway , 2021, Frontiers in Pharmacology.

[2]  X. Niu,et al.  Beta3-Adrenergic Receptor Activation Alleviates Cardiac Dysfunction in Cardiac Hypertrophy by Regulating Oxidative Stress , 2021, Oxidative medicine and cellular longevity.

[3]  Thomas D. Wang,et al.  Membrane bound Peroxiredoxin-1 serves as a biomarker for in vivo detection of sessile serrated adenomas. , 2021, Antioxidants & redox signaling.

[4]  W. Zong,et al.  Loss of TRIM21 alleviates cardiotoxicity by suppressing ferroptosis induced by the chemotherapeutic agent doxorubicin , 2021, EBioMedicine.

[5]  Yu-guo Liang,et al.  Pharmacological research progress of ursolic acid for the treatment of liver diseases , 2021, Traditional Medicine Research.

[6]  Jian Huang,et al.  MAP4K1 functions as a tumor promotor and drug mediator for AML via modulation of DNA damage/repair system and MAPK pathway. , 2021, EBioMedicine.

[7]  Xiang-chun Shen,et al.  MicroRNAs Regulating Mitochondrial Function in Cardiac Diseases , 2021, Frontiers in Pharmacology.

[8]  G. Batiha,et al.  Dapsone Ameliorates Isoproterenol-Induced Myocardial Infarction via Nrf2/ HO-1; TLR4/ TNF-α Signaling Pathways and the Suppression of Oxidative Stress, Inflammation, and Apoptosis in Rats , 2021, Frontiers in Pharmacology.

[9]  Zhang-bin Tan,et al.  Tanshinone I Inhibits Oxidative Stress–Induced Cardiomyocyte Injury by Modulating Nrf2 Signaling , 2021, Frontiers in Pharmacology.

[10]  Chang-Bo Zheng,et al.  Ang II Promotes Cardiac Autophagy and Hypertrophy via Orai1/STIM1 , 2021, Frontiers in Pharmacology.

[11]  Z. Wang,et al.  Redox-sensitive enzyme SENP3 mediates vascular remodeling via de-SUMOylation of β-catenin and regulation of its stability , 2021, EBioMedicine.

[12]  M. Jeong,et al.  Selective HDAC8 Inhibition Attenuates Isoproterenol-Induced Cardiac Hypertrophy and Fibrosis via p38 MAPK Pathway , 2021, Frontiers in Pharmacology.

[13]  Xiaoying Lin,et al.  Qingda granule attenuates angiotensin II-induced cardiac hypertrophy and apoptosis and modulates the PI3K/AKT pathway. , 2021, Biomedicine & pharmacotherapy = Biomedecine & pharmacotherapie.

[14]  Guangping Li,et al.  Hyperglycemia Induces Endoplasmic Reticulum Stress in Atrial Cardiomyocytes, and Mitofusin-2 Downregulation Prevents Mitochondrial Dysfunction and Subsequent Cell Death , 2020, Oxidative medicine and cellular longevity.

[15]  Da-Zhi Wang,et al.  tRNA-Derived Small RNAs and Their Potential Roles in Cardiac Hypertrophy , 2020, Frontiers in Pharmacology.

[16]  Jun Li,et al.  LCZ696 Ameliorates Oxidative Stress and Pressure Overload-Induced Pathological Cardiac Remodeling by Regulating the Sirt3/MnSOD Pathway , 2020, Oxidative medicine and cellular longevity.

[17]  M. Gyöngyösi,et al.  New Insights and Current Approaches in Cardiac Hypertrophy Cell Culture, Tissue Engineering Models, and Novel Pathways Involving Non-Coding RNA , 2020, Frontiers in Pharmacology.

[18]  Melanie Y. White,et al.  A global profile of reversible and irreversible cysteine redox post-translational modifications during myocardial ischemia / reperfusion injury and antioxidant intervention. , 2020, Antioxidants & redox signaling.

[19]  Chaoliang Tang,et al.  Peroxiredoxin-1 Overexpression Attenuates Doxorubicin-Induced Cardiotoxicity by Inhibiting Oxidative Stress and Cardiomyocyte Apoptosis , 2020, Oxidative medicine and cellular longevity.

[20]  Hui-Hua Li,et al.  Gallic Acid Attenuates Angiotensin II-Induced Hypertension and Vascular Dysfunction by Inhibiting the Degradation of Endothelial Nitric Oxide Synthase , 2020, Frontiers in Pharmacology.

[21]  S. Banerjee,et al.  Allylmethylsulfide, a Sulfur Compound Derived from Garlic, Attenuates Isoproterenol-Induced Cardiac Hypertrophy in Rats , 2020, Oxidative medicine and cellular longevity.

[22]  Chunxia Huang,et al.  Peroxiredoxin-1 ameliorates pressure overload-induced cardiac hypertrophy and fibrosis. , 2020, Biomedicine & pharmacotherapy = Biomedecine & pharmacotherapie.

[23]  Q. Jin,et al.  Wenxin Granule Ameliorates Hypoxia/Reoxygenation-Induced Oxidative Stress in Mitochondria via the PKC-δ/NOX2/ROS Pathway in H9c2 Cells , 2020, Oxidative medicine and cellular longevity.

[24]  F. Giorgino,et al.  The Role of Oxidative Stress in Cardiac Disease: From Physiological Response to Injury Factor , 2020, Oxidative medicine and cellular longevity.

[25]  V. Schini-Kerth,et al.  Unveiling the Role of Inflammation and Oxidative Stress on Age-Related Cardiovascular Diseases , 2020, Oxidative medicine and cellular longevity.

[26]  Lailai Yan,et al.  Dracocephalum moldavica L. Extracts Protect H9c2 Cardiomyocytes against H2O2-Induced Apoptosis and Oxidative Stress , 2020, BioMed research international.

[27]  G. P. Caviglia.  Edaravone and MAPK pathway: the key role of gut permeability. , 2020, Minerva medica.

[28]  Jingliang Cheng,et al.  Danhong Injection Protects Hemorrhagic Brain by Increasing Peroxiredoxin 1 in Aged Rats , 2020, Frontiers in Pharmacology.

[29]  M. He,et al.  Capsaicin Alleviates the Deteriorative Mitochondrial Function by Upregulating 14-3-3η in Anoxic or Anoxic/Reoxygenated Cardiomyocytes , 2020, Oxidative medicine and cellular longevity.

[30]  Yuanyuan Xie,et al.  Elevated myocardial SORBS2 and the underlying implications in left ventricular noncompaction cardiomyopathy , 2020, EBioMedicine.

[31]  Liping Gao,et al.  Decellularized Aortic Scaffold Alleviates H2O2-Induced Inflammation and Apoptosis in CD34+ Progenitor Cells While Driving Neovasculogenesis , 2020, BioMed research international.

[32]  S. Kumari,et al.  Musa balbisiana Fruit Rich in Polyphenols Attenuates Isoproterenol-Induced Cardiac Hypertrophy in Rats via Inhibition of Inflammation and Oxidative Stress , 2020, Oxidative medicine and cellular longevity.

[33]  Ben Li,et al.  PRDX5 as a novel binding partner in Nrf2-mediated NSCLC progression under oxidative stress , 2020, Aging.

[34]  H. Huikuri,et al.  Vezf1 regulates cardiac structure and contractile function , 2020, EBioMedicine.

[35]  Si-Yue Tao,et al.  The Prognosis Of Peroxiredoxin Family In Breast Cancer , 2019, Cancer management and research.

[36]  Y. Bae,et al.  Peroxiredoxin 5 Inhibits Glutamate-Induced Neuronal Cell Death through the Regulation of Calcineurin-Dependent Mitochondrial Dynamics in HT22 Cells , 2019, Molecular and Cellular Biology.

[37]  Jong-Yeon Shin,et al.  Peroxiredoxin5 Controls Vertebrate Ciliogenesis by Modulating Mitochondrial Reactive Oxygen Species. , 2019, Antioxidants & redox signaling.

[38]  K. Tanonaka,et al.  Heat-shock protein 90 modulates cardiac ventricular hypertrophy via activation of MAPK pathway. , 2019, Journal of molecular and cellular cardiology.

[39]  Sun-Ji Park,et al.  Peroxiredoxin 5 regulates adipogenesis‐attenuating oxidative stress in obese mouse models induced by a high‐fat diet , 2018, Free radical biology & medicine.

[40]  J. Sadoshima,et al.  Mechanisms of physiological and pathological cardiac hypertrophy , 2018, Nature Reviews Cardiology.

[41]  S. Rhee,et al.  The Role of Peroxiredoxins in the Transduction of H2O2 Signals. , 2017, Antioxidants & redox signaling.

[42]  P. Zhang,et al.  A Long Non-Coding RNA Defines an Epigenetic Checkpoint in Cardiac Hypertrophy , 2016 .

[43]  Jean-Paul Declercq,et al.  Peroxiredoxin 5: structure, mechanism, and function of the mammalian atypical 2-Cys peroxiredoxin. , 2011, Antioxidants & redox signaling.

[44]  K. Sunagawa,et al.  Overexpression of Mitochondrial Peroxiredoxin-3 Prevents Left Ventricular Remodeling and Failure After Myocardial Infarction in Mice , 2006, Circulation.

[45]  P. Gressens,et al.  Recombinant peroxiredoxin 5 protects against excitotoxic brain lesions in newborn mice. , 2003, Free radical biology & medicine.

[46]  Zhaiyi Zhang,et al.  Jian-Gan-Xiao-Zhi decoction ameliorates high-fat high-carbohydrate diet-induced non-alcoholic fatty liver disease and insulin resistance by regulating the AMPK/JNK pathway , 2021, Traditional Medicine Research.