Necrotizing Pneumonia in Children: Early Recognition and Management

Necrotizing pneumonia (NP) is an uncommon complicated pneumonia with an increasing incidence. Early recognition and timely management can bring excellent outcomes. The diagnosis of NP depends on chest computed tomography, which has radiation damage and may miss the optimal treatment time. The present review aimed to elaborate on the reported predictors for NP. The possible pathogenesis of Streptococcus pneumoniae, Staphylococcus aureus, Mycoplasma pneumoniae and coinfection, clinical manifestations and management were also discussed. Although there is still a long way for these predictors to be used in clinical, it is necessary to investigate early predictors for NP in children.

[1]  F. Zarb,et al.  Optimisation of the CT pulmonary angiogram (CTPA) protocol using a low kV technique combined with high iterative reconstruction (IR): A phantom study. , 2023, Radiography.

[2]  C. Aytekin,et al.  Surfactant for a Patient with Refractory Pyopneumothorax and Acute Respiratory Distress Syndrome Due to Pneumococcal Necrotizing Pneumonia Complicated by a Bronchopleural Fistula. , 2022, Pediatric allergy, immunology, and pulmonology.

[3]  J. Meuwly,et al.  Necrotizing pneumonia in children: Chest computed tomography vs. lung ultrasound , 2022, Frontiers in Pediatrics.

[4]  Tongqiang Zhang,et al.  Successful treatment of pleural empyema and necrotizing pneumonia caused by methicillin-resistant Staphylococcus aureus infection following influenza A virus infection: A case report and literature review , 2022, Frontiers in Pediatrics.

[5]  Y. Lee,et al.  Clinical significance of respiratory virus coinfection in children with Mycoplasma pneumoniae pneumonia , 2022, BMC Pulmonary Medicine.

[6]  R. Lu,et al.  Mycoplasma pneumoniae and Adenovirus Coinfection Cause Pediatric Severe Community-Acquired Pneumonia , 2022, Microbiology spectrum.

[7]  Changchong Li,et al.  Early predictors of lung necrosis severity in children with community‐acquired necrotizing pneumonia , 2021, Pediatric pulmonology.

[8]  Yuan Li,et al.  Increased Total Serum Immunoglobulin E Is Likely to Cause Complications of Mycoplasma pneumoniae Pneumonia in Children , 2021, Frontiers in Cellular and Infection Microbiology.

[9]  Remon M. Yousef,et al.  Serum Albumin Level as a Predictor of Outcome in Patients Admitted to Pediatric Intensive Care Units , 2021, Pediatric emergency care.

[10]  S. Monecke,et al.  Lateral Flow Immunoassay for the Detection of Panton-Valentine Leukocidin in Staphylococcus aureus From Skin and Soft Tissue Infections in the United Arab Emirates , 2021, Frontiers in Cellular and Infection Microbiology.

[11]  C. Atkinson,et al.  Multiple anatomic sites of infarction in a pediatric patient with M. pneumoniae infection, a case report , 2021, BMC Pediatrics.

[12]  H. Liu,et al.  [A multicenter retrospective study on the etiology of necrotizing pneumonia in children]. , 2021, Zhonghua er ke za zhi = Chinese journal of pediatrics.

[13]  L. Lança,et al.  The use of deep learning towards dose optimization in low-dose computed tomography: A scoping review. , 2021, Radiography.

[14]  B. Totapally,et al.  Characteristics and Outcomes of Children With Necrotizing Pneumonia. , 2021, Pediatric critical care medicine : a journal of the Society of Critical Care Medicine and the World Federation of Pediatric Intensive and Critical Care Societies.

[15]  Lingling Hua,et al.  The Level of D-Dimer Is Positively Correlated With the Severity of Mycoplasma pneumoniae Pneumonia in Children , 2021, Frontiers in Cellular and Infection Microbiology.

[16]  J. Carapetis,et al.  Pediatric Staphylococcus aureus bacteremia: clinical spectrum and predictors of poor outcome. , 2021, Clinical infectious diseases : an official publication of the Infectious Diseases Society of America.

[17]  Fang Wang,et al.  Early recognition of necrotizing pneumonia in children based on non-contrast-enhanced computed tomography radiomics signatures , 2021, Translational pediatrics.

[18]  A. Alomari,et al.  Nonsurgical management of dynamic pneumatocele via endobronchial administration of fibrin sealant , 2021, Pediatric pulmonology.

[19]  Zhengrong Chen,et al.  Differences of clinical features and prognosis between Mycoplasma pneumoniae necrotizing pneumonia and non-Mycoplasma pneumoniae necrotizing pneumonia in children , 2021, BMC Infectious Diseases.

[20]  Y. Sguassero,et al.  Community-acquired methicillin-resistant Staphylococcus aureus pneumonia in a children's hospital. Our ten-year experience. , 2021, Archivos argentinos de pediatria.

[21]  M. Kubo,et al.  Panton-Valentine leukocidin induces cytokine release and cytotoxicity mediated by the C5a receptor on rabbit alveolar macrophages. , 2021, Japanese journal of infectious diseases.

[22]  W. Guo,et al.  Clinical characteristics of refractory mycoplasma pneumoniae pneumonia in children treated with glucocorticoid pulse therapy , 2020, BMC Infectious Diseases.

[23]  I. Carloni,et al.  Necrotizing pneumonia among Italian children in the pneumococcal conjugate vaccine era , 2020, Pediatric pulmonology.

[24]  T. Dandekar,et al.  Intracellular Staphylococcus aureus Perturbs the Host Cell Ca2+ Homeostasis To Promote Cell Death , 2020, mBio.

[25]  Zhimin Chen,et al.  Early prediction of necrotizing pneumonia from mycoplasma pneumoniae pneumonia with large pulmonary lesions in children , 2020, Scientific Reports.

[26]  Shanjia Chen,et al.  Pulmonary embolism associated with mycoplasma in a child. , 2020, The Lancet. Infectious diseases.

[27]  C. Muñoz-Almagro,et al.  Necrotizing pneumonia due to Streptococcus pneumoniae in children during the period of non-systematic use of PCV13 in Catalonia, Spain. , 2020, Enfermedades infecciosas y microbiologia clinica.

[28]  Hong-Ren Yu,et al.  Rational stepwise approach for Mycoplasma pneumoniae pneumonia in children. , 2020, Journal of microbiology, immunology, and infection = Wei mian yu gan ran za zhi.

[29]  Ting-Yu Yen,et al.  Severe Mycoplasma pneumoniae pneumonia requiring intensive care in children, 2010-2019. , 2020, Journal of the Formosan Medical Association = Taiwan yi zhi.

[30]  Yimou Wu,et al.  Mycoplasma pneumoniae lipids license TLR‐4 for activation of NLRP3 inflammasome and autophagy to evoke a proinflammatory response , 2020, Clinical and experimental immunology.

[31]  H. Zar,et al.  Complicated pneumonia in children , 2020, The Lancet.

[32]  Tu-Hsuan Chang,et al.  Macrolide-Resistant Mycoplasma pneumoniae Infections in Pediatric Community-Acquired Pneumonia , 2020 .

[33]  C. Mackay,et al.  Targeting NLRP3 and Staphylococcal pore‐forming toxin receptors in human‐induced pluripotent stem cell‐derived macrophages , 2020, Journal of leukocyte biology.

[34]  J. Zhao,et al.  The clinical characteristics and risk factors for necrotizing pneumonia caused by Mycoplasma pneumoniae in children , 2020, BMC Infectious Diseases.

[35]  N. Shen,et al.  Impact of viral coinfection and macrolide-resistant mycoplasma infection in children with refractory Mycoplasma pneumoniae pneumonia , 2020, BMC Infectious Diseases.

[36]  S. Lancel,et al.  Influenza infection rewires energy metabolism and induces browning features in adipose cells and tissues , 2020, Communications Biology.

[37]  A. Raposo,et al.  Influenza virus infection complicated by bacterial necrotising pneumonia: two case reports , 2020, Paediatrics and international child health.

[38]  Christian Prado,et al.  Surgical treatment of necrotizing pneumonia in children: a 10-year assessment. , 2020, Revista do Colegio Brasileiro de Cirurgioes.

[39]  Jinrong Liu,et al.  Mycoplasma pneumoniae pneumonia associated thrombosis at Beijing Children’s hospital , 2020, BMC infectious diseases.

[40]  K. Kashani,et al.  Impacts of Admission Serum Albumin Levels on Short-Term and Long-Term Mortality in Hospitalized Patients. , 2019, QJM : monthly journal of the Association of Physicians.

[41]  C. Bost-Bru,et al.  Splenic infarction associated with transient anti-prothrombin antibodies is a rare manifestation of acute Mycoplasma pneumoniae infection. , 2019, Archives de pediatrie : organe officiel de la Societe francaise de pediatrie.

[42]  E. Kerem,et al.  Giant lung cysts following necrotizing pneumonia: Resolution with conservative treatment , 2019, Pediatric pulmonology.

[43]  C. Muñoz-Almagro,et al.  Complicated pneumococcal pneumonia with pleural effusion or empyema in the 13‐valent pneumococcal conjugate vaccine era , 2019, Pediatric pulmonology.

[44]  I. Carloni,et al.  Significant impact of pneumococcal conjugate vaccination on pediatric parapneumonic effusion: Italy 2006-2018. , 2019, Vaccine.

[45]  Katherine J. Siegel,et al.  Vancomycin Monotherapy May Be Insufficient to Treat Methicillin-resistant Staphylococcus aureus Coinfection in Children With Influenza-related Critical Illness , 2018, Clinical infectious diseases : an official publication of the Infectious Diseases Society of America.

[46]  G. Turc,et al.  Stroke Associated With Recent Mycoplasma Pneumoniae Infection: A Systematic Review of Clinical Features and Presumed Pathophysiological Mechanisms , 2018, Front. Neurol..

[47]  E. Chung,et al.  The changes of prevalence and etiology of pediatric pneumonia from National Emergency Department Information System in Korea, between 2007 and 2014 , 2018, Korean journal of pediatrics.

[48]  Zhimin Chen,et al.  Necrotizing pneumonia caused by refractory Mycoplasma pneumonia pneumonia in children , 2018, World Journal of Pediatrics.

[49]  P. Goussard,et al.  Mycobacterium tuberculosis, a cause of necrotising pneumonia in childhood: a case series. , 2018, The international journal of tuberculosis and lung disease : the official journal of the International Union against Tuberculosis and Lung Disease.

[50]  J. McQuiston,et al.  Necrotizing Pneumonia Caused by Chromobacterium violaceum: Report of a Rare Human Pathogen Causing Disease in an Immunodeficient Child. , 2018, The American journal of tropical medicine and hygiene.

[51]  Hyunju Lee,et al.  Antimicrobial therapy of macrolide-resistant Mycoplasma pneumoniae pneumonia in children , 2018, Expert review of anti-infective therapy.

[52]  J. Eikelboom,et al.  A Test in Context: D-Dimer. , 2017, Journal of the American College of Cardiology.

[53]  J. Baseman,et al.  NLRP3 Is a Critical Regulator of Inflammation and Innate Immune Cell Response during Mycoplasma pneumoniae Infection , 2017, Infection and Immunity.

[54]  F. Huang,et al.  Predictive value of Thomsen-Friedenreich antigen activation for Streptococcus pneumoniae infection and severity in pediatric lobar pneumonia. , 2017, Journal of microbiology, immunology, and infection = Wei mian yu gan ran za zhi.

[55]  J. Stülke,et al.  Glycerol metabolism and its implication in virulence in Mycoplasma. , 2017, FEMS microbiology reviews.

[56]  Samir S. Shah,et al.  Emerging Biomarkers of Illness Severity: Urinary Metabolites Associated with Sepsis and Necrotizing Methicillin‐Resistant Staphylococcus aureus Pneumonia , 2017, Pharmacotherapy.

[57]  I. Masters,et al.  Necrotizing pneumonia: an emerging problem in children? , 2017, Pneumonia.

[58]  E. Gulbins,et al.  Staphylococcus aureus Survives in Cystic Fibrosis Macrophages, Forming a Reservoir for Chronic Pneumonia , 2017, Infection and Immunity.

[59]  F. Gleeson,et al.  State-of-the-art: Radiological investigation of pleural disease. , 2017, Respiratory medicine.

[60]  L. Prokai,et al.  Targeting Alpha Toxin To Mitigate Its Lethal Toxicity in Ferret and Rabbit Models of Staphylococcus aureus Necrotizing Pneumonia , 2017, Antimicrobial Agents and Chemotherapy.

[61]  S. Kaveri,et al.  Tackling Difficult Staphylococcus aureus Infections: Antibodies Show the Way. , 2016, Cell host & microbe.

[62]  Karan Uppal,et al.  Metabolic pathways of lung inflammation revealed by high-resolution metabolomics (HRM) of H1N1 influenza virus infection in mice. , 2016, American journal of physiology. Regulatory, integrative and comparative physiology.

[63]  Pei-Fen Liao,et al.  Necrotizing pneumonia and acute purulent pericarditis caused by Streptococcus pneumoniae serotype 19A in a healthy 4-year-old girl after one catch-up dose of 13-valent pneumococcal conjugate vaccine , 2016, Paediatrics and international child health.

[64]  P. Saftig,et al.  Dissecting the role of ADAM10 as a mediator of Staphylococcus aureus α-toxin action. , 2016, The Biochemical journal.

[65]  Yuhuan Liu,et al.  [Early predictors of necrotizing pneumonia in children]. , 2016, Zhongguo dang dai er ke za zhi = Chinese journal of contemporary pediatrics.

[66]  V. Chow,et al.  Lethal Synergism between Influenza and Streptococcus pneumoniae , 2016, Journal of infectious pulmonary diseases.

[67]  J. Vallejo,et al.  Healthcare-associated Staphylococcus aureus Bacteremia in Children: Evidence for Reverse Vancomycin Creep and Impact of Vancomycin Trough Values on Outcome , 2016, The Pediatric infectious disease journal.

[68]  C. Chiu,et al.  Low Serum Fetuin-A as a Biomarker to Predict Pneumococcal Necrotizing Pneumonia and Hemolytic Uremic Syndrome in Children , 2016, Medicine.

[69]  F. Vandenesch,et al.  α‐Defensins partially protect human neutrophils against Panton‐Valentine leukocidin produced by Staphylococcus aureus , 2015, Letters in applied microbiology.

[70]  S. Liao,et al.  Value of Lung Ultrasonography in the Diagnosis and Outcome Prediction of Pediatric Community-Acquired Pneumonia with Necrotizing Change , 2015, PloS one.

[71]  M. Nahm,et al.  Pneumococcal Capsules and Their Types: Past, Present, and Future , 2015, Clinical Microbiology Reviews.

[72]  Zhonghua Sun,et al.  Use of 100 kV versus 120 kV in computed tomography pulmonary angiography in the detection of pulmonary embolism: effect on radiation dose and image quality. , 2015, Quantitative imaging in medicine and surgery.

[73]  Yhu-Chering Huang,et al.  Increase in Fitness of Streptococcus pneumoniae Is Associated With the Severity of Necrotizing Pneumonia , 2015, The Pediatric infectious disease journal.

[74]  A. Prince,et al.  Toxin-Induced Necroptosis Is a Major Mechanism of Staphylococcus aureus Lung Damage , 2015, PLoS pathogens.

[75]  D. Klenerman,et al.  Lipid peroxidation is essential for α‐synuclein‐induced cell death , 2015, Journal of neurochemistry.

[76]  Anami R Patel,et al.  Community-acquired pneumonia requiring hospitalization among U.S. children. , 2015, The New England journal of medicine.

[77]  M. Kulus,et al.  Necrotizing Pneumonia and Its Complications in Children. , 2015, Advances in experimental medicine and biology.

[78]  C. Feldman,et al.  Recent advances in our understanding of Streptococcus pneumoniae infection , 2014, F1000prime reports.

[79]  Matthew F. Thomas,et al.  Necrotising pneumonia in children. , 2014, Paediatric respiratory reviews.

[80]  Zhimin Chen,et al.  Effects of Bronchoalveolar Lavage on Refractory Mycoplasma pneumoniae Pneumonia , 2014, Respiratory Care.

[81]  I. Guler,et al.  Cystic and Cavitary Lung Lesions in Children: Radiologic Findings with Pathologic Correlation , 2013, Journal of clinical imaging science.

[82]  M. Alison,et al.  Necrotizing Pneumonia in Children: Report of 41 Cases Between 2006 and 2011 in a French Tertiary Care Center , 2013, The Pediatric infectious disease journal.

[83]  D. Stevens,et al.  Staphylococcus aureus α-hemolysin promotes platelet-neutrophil aggregate formation. , 2013, The Journal of infectious diseases.

[84]  P. Schlievert,et al.  Staphylococcal and Streptococcal Superantigen Exotoxins , 2013, Clinical Microbiology Reviews.

[85]  K. Shen,et al.  Combination therapy with immune‐modulators and moxifloxacin on fulminant macrolide‐resistant Mycoplasma pneumoniae infection: A case report , 2013, Pediatric pulmonology.

[86]  N. Khanafer,et al.  Methicillin resistance is not a predictor of severity in community-acquired Staphylococcus aureus necrotizing pneumonia--results of a prospective observational study. , 2013, Clinical microbiology and infection : the official publication of the European Society of Clinical Microbiology and Infectious Diseases.

[87]  B. Söderquist,et al.  Rapid Detection of Panton-Valentine Leukocidin in Staphylococcus aureus Cultures by Use of a Lateral Flow Assay Based on Monoclonal Antibodies , 2012, Journal of Clinical Microbiology.

[88]  C. Ehrhardt,et al.  Combined Action of Influenza Virus and Staphylococcus aureus Panton–Valentine Leukocidin Provokes Severe Lung Epithelium Damage , 2012, The Journal of infectious diseases.

[89]  N. Curtis,et al.  The Role of Panton-Valentine Leukocidin in Staphylococcus aureus Musculoskeletal Infections in Children , 2012, The Pediatric infectious disease journal.

[90]  Zhimin Chen,et al.  Mycoplasma pneumoniae‐associated necrotizing pneumonitis in children , 2012, Pediatrics international : official journal of the Japan Pediatric Society.

[91]  Robin R. Chamberland,et al.  Staphylococcus aureus α-hemolysin mediates virulence in a murine model of severe pneumonia through activation of the NLRP3 inflammasome. , 2012, The Journal of infectious diseases.

[92]  Se Jin Park,et al.  Fulminant and Fatal Multiple Organ Failure in a 12-Year-Old Boy With Mycoplasma pneumoniae Infection , 2011, Allergy, asthma & immunology research.

[93]  B. Alexander,et al.  Fungal Diagnostics in Pneumonia , 2011, Seminars in respiratory and critical care medicine.

[94]  C. Chiu,et al.  Necrotizing Pneumococcal Pneumonia With Bronchopleural Fistula Among Children in Taiwan , 2011, The Pediatric infectious disease journal.

[95]  N. MacDonald,et al.  Severe necrotizing pneumonia in a child with pandemic (H1N1) influenza , 2011, Canadian Medical Association Journal.

[96]  Jack K. Sharp,et al.  Bronchoscopic findings in a child with pandemic novel H1N1 influenza a and methicillin‐resistant Staphylococcus aureus , 2011, Pediatric pulmonology.

[97]  Rebecca A Buonpane,et al.  Staphylococcal superantigens cause lethal pulmonary disease in rabbits. , 2010, The Journal of infectious diseases.

[98]  Edson de Oliveira Andrade,et al.  Surgical treatment of children with necrotizing pneumonia. , 2010, Jornal brasileiro de pneumologia : publicacao oficial da Sociedade Brasileira de Pneumologia e Tisilogia.

[99]  K. O'Brien,et al.  Systematic Evaluation of Serotypes Causing Invasive Pneumococcal Disease among Children Under Five: The Pneumococcal Global Serotype Project , 2010, PLoS medicine.

[100]  J. Edgeworth,et al.  Novel H1N1 influenza and Panton-Valentine leukocidin Staphylococcus aureus necrotizing pneumonia. , 2010, British journal of hospital medicine.

[101]  K. Meyer,et al.  Necrotizing pneumonia in children submitted to thoracoscopy due to pleural empyema: incidence, treatment and clinical evolution. , 2010, Jornal brasileiro de pneumologia : publicacao oficial da Sociedade Brasileira de Pneumologia e Tisilogia.

[102]  Adeline R. Whitney,et al.  Polymorphonuclear leukocytes mediate Staphylococcus aureus Panton-Valentine leukocidin-induced lung inflammation and injury , 2010, Proceedings of the National Academy of Sciences.

[103]  F. Vandenesch,et al.  Prompt and Successful Toxin-Targeting Treatment of Three Patients with Necrotizing Pneumonia Due to Staphylococcus aureus Strains Carrying the Panton-Valentine Leukocidin Genes , 2010, Journal of Clinical Microbiology.

[104]  F. Vandenesch,et al.  Rapid Detection of Staphylococcus aureus Panton-Valentine Leukocidin in Clinical Specimens by Enzyme-Linked Immunosorbent Assay and Immunochromatographic Tests , 2010, Journal of Clinical Microbiology.

[105]  T. Tsaganos,et al.  Effect of the Novel Influenza A (H1N1) Virus in the Human Immune System , 2009, PLoS ONE.

[106]  Jeremy S. Brown,et al.  The Streptococcuspneumoniae Capsule Inhibits Complement Activity and Neutrophil Phagocytosis by Multiple Mechanisms , 2009, Infection and Immunity.

[107]  D. Raoult,et al.  MALDI-TOF-MS for rapid detection of staphylococcal Panton-Valentine leukocidin. , 2009, International journal of antimicrobial agents.

[108]  J. McEniery,et al.  Therapeutic bronchoscopy in a child with sand aspiration and respiratory failure from near drowning—case report and literature review , 2009, Pediatric pulmonology.

[109]  T. Cherian,et al.  Burden of disease caused by Streptococcus pneumoniae in children younger than 5 years: global estimates , 2009, The Lancet.

[110]  Yung‐Chie Lee,et al.  Pediatric empyema: Outcome analysis of thoracoscopic management. , 2009, The Journal of thoracic and cardiovascular surgery.

[111]  S. Engelmann,et al.  Effects of Staphylococcus aureus-hemolysin A on calcium signalling in immortalized human airway epithelial cells. , 2009, Cell calcium.

[112]  W. Permanetter,et al.  Rapidly Fatal Necrotizing Pneumonia in a 12-Year-Old Boy Caused by Co-Infection with Parainfluenza Virus Type 1 and Panton-Valentine Leukocidin (PVL)-Positive Methicillin-Sensitive Staphylococcus aureus , 2009, Infection.

[113]  T. Baba,et al.  A latex agglutination assay for specific detection of Panton-Valentine leukocidin. , 2008, Journal of microbiological methods.

[114]  R. Ulloa-Gutiérrez.  Pneumococcal necrotizing pneumonia and pleural fluid lactate dehydrogenase level. , 2008, Clinical infectious diseases : an official publication of the Infectious Diseases Society of America.

[115]  G. Sawicki,et al.  Necrotising pneumonia is an increasingly detected complication of pneumonia in children , 2008, European Respiratory Journal.

[116]  C. Byington,et al.  Pneumococcal necrotizing pneumonia in Utah: does serotype matter? , 2006, Clinical infectious diseases : an official publication of the Infectious Diseases Society of America.

[117]  P. Vanhems,et al.  Factors predicting mortality in necrotizing community-acquired pneumonia caused by Staphylococcus aureus containing Panton-Valentine leukocidin. , 2007, Clinical infectious diseases : an official publication of the Infectious Diseases Society of America.

[118]  E. Delong,et al.  Staphylococcus aureus Panton-Valentine Leukocidin Causes Necrotizing Pneumonia , 2007, Science.

[119]  J. Erjefält,et al.  Direct evidence of secondary necrosis of neutrophils during intense lung inflammation , 2006, European Respiratory Journal.

[120]  A. Nelson,et al.  Epithelial Cells Are Sensitive Detectors of Bacterial Pore-forming Toxins* , 2006, Journal of Biological Chemistry.

[121]  J. Baseman,et al.  ADP-ribosylating and vacuolating cytotoxin of Mycoplasma pneumoniae represents unique virulence determinant among bacterial pathogens. , 2006, Proceedings of the National Academy of Sciences of the United States of America.

[122]  S. Clarke,et al.  Identification of Invasive Serotype 1 Pneumococcal Isolates That Express Nonhemolytic Pneumolysin , 2006, Journal of Clinical Microbiology.

[123]  S. Kaplan,et al.  Pulmonary manifestations in children with invasive community-acquired Staphylococcus aureus infection. , 2005, Clinical infectious diseases : an official publication of the Infectious Diseases Society of America.

[124]  A. Ayed,et al.  Lung resection in children for infectious pulmonary diseases , 2005, Pediatric Surgery International.

[125]  P. Andrew,et al.  The role of pneumolysin in pneumococcal pneumonia and meningitis , 2004, Clinical and experimental immunology.

[126]  B. Söderquist,et al.  Detection of Panton-Valentine leukocidin gene in Staphylococcus aureus by LightCycler PCR: clinical and epidemiological aspects. , 2004, Clinical microbiology and infection : the official publication of the European Society of Clinical Microbiology and Infectious Diseases.

[127]  Y. Chiou,et al.  Necrotizing pneumonitis caused by Mycoplasma pneumoniae in pediatric patients: report of five cases and review of literature. , 2004, The Pediatric infectious disease journal.

[128]  Chin‐Yun Lee,et al.  Clinical manifestations and molecular epidemiology of necrotizing pneumonia and empyema caused by Streptococcus pneumoniae in children in Taiwan. , 2004, Clinical infectious diseases : an official publication of the Infectious Diseases Society of America.

[129]  J. McCullers,et al.  Respiratory viruses predisposing to bacterial infections: role of neuraminidase , 2004, The Pediatric infectious disease journal.

[130]  O. Dittrich‐Breiholz,et al.  Multiple control of interleukin‐8 gene expression , 2002, Journal of leukocyte biology.

[131]  D. Fitzgerald,et al.  Multiple mechanisms for the activation of human platelet aggregation by Staphylococcus aureus: roles for the clumping factors ClfA and ClfB, the serine–aspartate repeat protein SdrE and protein A , 2002, Molecular microbiology.

[132]  P. Vanhems,et al.  Association between Staphylococcus aureus strains carrying gene for Panton-Valentine leukocidin and highly lethal necrotising pneumonia in young immunocompetent patients , 2002, The Lancet.

[133]  S. Dowell,et al.  Policy Statement: Recommendations for the Prevention of Pneumococcal Infections, Including the Use of Pneumococcal Conjugate Vaccine (Prevnar), Pneumococcal Polysaccharide Vaccine, and Antibiotic Prophylaxis , 2000, Pediatrics.

[134]  S. Szmigielski,et al.  Leukocidal toxins of staphylococci. , 1999, Zentralblatt fur Bakteriologie : international journal of medical microbiology.

[135]  L. Donnelly,et al.  Cavitary necrosis complicating pneumonia in children: sequential findings on chest radiography. , 1998, AJR. American journal of roentgenology.

[136]  W. König,et al.  Effects of Staphylococcus aureus leukocidins on inflammatory mediator release from human granulocytes. , 1995, The Journal of infectious diseases.

[137]  E. Kerem,et al.  Bacteremic necrotizing pneumococcal pneumonia in children. , 1994, American journal of respiratory and critical care medicine.

[138]  P. Andrew,et al.  Complement activation and antibody binding by pneumolysin via a region of the toxin homologous to a human acute‐phase protein , 1991, Molecular microbiology.

[139]  I. Kahane,et al.  Role of superoxide anion in host cell injury induced by mycoplasma pneumoniae infection. A study in normal and trisomy 21 cells. , 1984, The Journal of clinical investigation.

[140]  H. Schaefer,et al.  THOMSEN FRIEDENREICH ANTIGEN IN HÆMOLYTIC-URÆMIC SYNDROME , 1977, The Lancet.

[141]  R. Chanock,et al.  Hemolysin of Mycoplasma pneumoniae: Tentative Identification as a Peroxide , 1965, Science.