Mood and memory changes in asthmatic children receiving corticosteroids.

Abstract Each of 27 severely asthmatic 8− to 16-year-old children was evaluated at high (61.5 mg/day) and low (3.33 mg/day) steroid levels. At the high steroid level, patients reported increased depressive and anxious symptoms and performed less proficiently on a test of long-term verbal memory. No high-low steroid differences were found on measures of attention, impulsivity, hyperactivity, or motor control. The mood and memory differences were not associated with order of high and low dose, theophylline levels, or pulmonary function. Changes were generally subtle, and no evidence of steroid-induced psychiatric disturbance was documented.

[1]  S. Lindgren,et al.  Effects of theophylline on learning and behavior: reason for concern or concern without reason? , 1987, The Journal of pediatrics.

[2]  M. R. Mickey,et al.  Behavior abnormalities and poor school performance due to oral theophylline use. , 1986, Pediatrics.

[3]  D. Mitchell,et al.  Do corticosteroids really alter mood? , 1984, Postgraduate medical journal.

[4]  D. A. Lewis,et al.  Steroid-induced psychiatric syndromes. A report of 14 cases and a review of the literature. , 1983, Journal of affective disorders.

[5]  A. Fauci,et al.  Relationship between alternate-day corticosteroid therapy and behavioral abnormalities. , 1982, JAMA.

[6]  J. F. Dirks,et al.  The influence of corticosteroids and theophylline on cerebral function. A review. , 1982, Chest.

[7]  C. Cordess,et al.  Psychiatric Effects of Alternate Day Steroid Therapy , 1981, British Journal of Psychiatry.

[8]  M. Tsuang,et al.  Side effects of corticosteroid therapy. Psychiatric aspects. , 1981, Archives of general psychiatry.

[9]  M. Kovács.  Rating scales to assess depression in school-aged children. , 1981, Acta paedopsychiatrica.

[10]  W. Suess,et al.  Neuropsychological correlates of asthma: brain damage or drug effects? , 1981, Journal of consulting and clinical psychology.

[11]  L. Baade,et al.  Neuropsychological correlates of severe asthma in children 9-14 years old. , 1980, Journal of consulting and clinical psychology.

[12]  L. Baade,et al.  Neuropsychological correlates of severe asthma in children 9–12 years old. , 1980 .

[13]  Michael Gordon.  The assessment of impulsivity and mediating behaviors in hyperactive and nonhyperactive boys , 1979, Journal of abnormal child psychology.

[14]  R. C. Hall,et al.  Presentation of the Steroid Psychoses , 1979, The Journal of nervous and mental disease.

[15]  Gillies Ah,et al.  Unwanted corticosteroid effects in childhood bone marrow failure, renal failure and brain damage: case report. , 1975 .

[16]  Herman Buschke,et al.  Selective reminding for analysis of memory and learning , 1973 .

[17]  J. Gillin,et al.  Acute Effect of a Glucocorticoid on Normal Human Sleep , 1972, Nature.

[18]  B. Kopell,et al.  Cortisol Effects on Averaged Evoked Potential, Alpha‐Rhythm, Time Estimation, and Two‐Flash Fusion Threshold , 1970, Psychosomatic medicine.

[19]  P. Weisberg,et al.  Analyses of DRL Behavior in Young Children , 1967, Psychological reports.

[20]  G. EstradaDeLaRiva.  Psychic and somatic changes observed in allergic children after prolonged steroid therapy. , 1958 .

[21]  H E ROSVOLD,et al.  A continuous performance test of brain damage. , 1956, Journal of consulting psychology.

[22]  G. Glaser,et al.  Intravenous hydrocortisone, corticotropin and the electroencephalogram. , 1955, A.M.A. archives of neurology and psychiatry.

[23]  P. Goolker,et al.  Psychic Effects of ACTH and Cortisone , 1953, Psychosomatic medicine.

[24]  M. Streifler,et al.  On the effect of cortisone on the electroencephalogram. , 1953, Confinia neurologica.

[25]  F. Braceland,et al.  Psychological response to corticotropin, cortisone, and related steroid substances; psychotic reaction types. , 1952, Journal of the American Medical Association.

[26]  J. Taylor,et al.  The relationship of anxiety to the conditioned eyelid response. , 1951, Journal of experimental psychology.

[27]  G. Glaser,et al.  Effects of pituitary adrenocorticotropic hormone (ACTH) therapy; electroencephalographic and neuropsychiatric changes in fifteen patients. , 1950, Journal of the American Medical Association.

[28]  J. Elkinton,et al.  EFFECTS OF PITUITARY ADRENOCORTICOTROPIC HORMONE (ACTH) THERAPY , 1949 .

[29]  F. Mott.  ARCHIVES OF NEUROLOGY AND PSYCHIATRY , 1923 .

[30]  W. Pierson,et al.  Cognitive and behavioral findings in children taking theophylline. , 1988, The Journal of allergy and clinical immunology.

[31]  L. Bloom,et al.  Potential neuropsychological side effects of theophylline in asthmatic children , 1987 .

[32]  B. Leventhal,et al.  Intermittent high dose corticosteroid treatment in childhood cancer: behavioral and emotional consequences. , 1986, Journal of the American Academy of Child Psychiatry.

[33]  D. Mrazek.  Childhood asthma: two central questions for child psychiatry. , 1986, Journal of child psychology and psychiatry, and allied disciplines.

[34]  W. Suess,et al.  Mnemonic effects of asthma medication in children. , 1986, The Journal of asthma : official journal of the Association for the Care of Asthma.

[35]  R. Henkin.  The effects of corticosteroids and ACTH on sensory systems. , 1970, Progress in brain research.

[36]  R. Michael,et al.  INTERRELATIONSHIPS BETWEEN THE ENDOCRINE SYSTEM NEUROPSYCHIATRY. , 1963, International review of neurobiology.