A Realistic Computational Model of the Local Circuitry of the Cuneate Nucleus

Intracellular recordings obtained under cutaneous and lemniscal stimulation show that the afferent fibers can establish excitatory and inhibitory synaptic connections with cuneothalamic neurons [5]. In addition, distinct types of recurrent collaterals with the capability of either exciting or inhibiting both cuneothalamic neurons and interneurons were also discovered [6]. With these data we have generated hypothesis about which circuits are implicated and also developed realistic computational models to test the hypothesis and study the cuneate properties [17,18]. The results show that the cuneate could perform spatial and temporal filtering and therefore detect dynamic edges.

[1]  Antonio Canedo,et al.  Sensorimotor Integration at the Dorsal Column Nuclei. , 1999, News in physiological sciences : an international journal of physiology produced jointly by the International Union of Physiological Sciences and the American Physiological Society.

[2]  A. Light,et al.  Intracellular staining study of the feline cuneate nucleus. II. Thalamic projecting neurons. , 1986, Journal of neurophysiology.

[3]  S. Cheema,et al.  Intracellular staining study of the feline cuneate nucleus. I. Terminal patterns of primary afferent fibers. , 1986, Journal of neurophysiology.

[4]  A. Canedo.  PRIMARY MOTOR CORTEX INFLUENCES ON THE DESCENDING AND ASCENDING SYSTEMS , 1997, Progress in Neurobiology.

[5]  M Hines,et al.  A program for simulation of nerve equations with branching geometries. , 1989, International journal of bio-medical computing.

[6]  Wilfrid Rall,et al.  Theoretical significance of dendritic trees for neuronal input-output relations , 1964 .

[7]  J J Jack,et al.  The propagation of transient potentials in some linear cable structures , 1971, The Journal of physiology.

[8]  Senén Barro,et al.  Modelling the Circuitry of the Cuneate Nucleus , 1999, IWANN.

[9]  J. Mariño,et al.  Coupled slow and delta oscillations between cuneothalamic and thalamocortical neurons in the chloralose anesthetized cat , 1996, Neuroscience Letters.

[10]  H. Kuypers,et al.  THE DISTRIBUTION OF THE CORTICAL FIBRES WITHIN THE NUCLEI CUNEATUS AND GRACILIS IN THE CAT. , 1964, Journal of anatomy.

[11]  M. Bull,et al.  Output systems of the dorsal column nuclei in the cat , 1986, Brain Research Reviews.

[12]  A. Hodgkin,et al.  Measurement of current‐voltage relations in the membrane of the giant axon of Loligo , 1952, The Journal of physiology.

[13]  A. Canedo,et al.  Spatial and cortical influences exerted on cuneothalamic and thalamocortical neurons of the cat , 2000, The European journal of neuroscience.

[14]  A. Canedo,et al.  Lemniscal recurrent and transcortical influences on cuneate neurons , 2000, Neuroscience.

[15]  O. L. Zangwill,et al.  Current problems in animal behaviour , 1962 .