New insights into the pathogenesis of asthma.

Asthma is a disease whose ability to cause episodicsymptomatology has been appreciated since antiqui-ty. Although the fine points of the definition can bedebated, it is reasonable to think of asthma as a pul-monary disorder characterized by the generalizedreversible obstruction of airflow and to definereversibility as a greater than 12% increase in thepatient’s forced expiratory volume in 1 second (FEV

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