[Study on effects of theraupetic and prophilactic toothpaste with NovaMin on oral cavity in young tobacco users].

THE AIM OF THE STUDY Was to assess the clinical effectiveness of the course use of toothpaste with NovaMin by smoking and nonsmoking patients along with its complex effects on the oral cavity. MATERIALS AND METHODS 75 young patients (46 males and 29 females, mean age 23.95±2.9 years) were divided into three groups of 25 individuals. The first group was composed of non-smoking patients using toothpaste with NovaMin. The second group (reference group) comprised patients using placebo toothpaste. The third group was composed of smoking patients using toothpaste with NovaMin. The clinical trials of patients included assessment of functional activity of minor salivary glands, the sialometric analysis, the study on microcrystallization of mixed saliva. The non-specific resistance of oral cavity was studied based on the analysis of absorption reaction of microorganisms by epithelial cells. All patients were questioned about the organoleptic characteristics of the toothpaste. The abovementioned features were assessed before the study, after the first use of the toothpaste, after day 7 and day 14. RESULTS The course use of toothpaste with NovaMin resulted in the plaque inhibiting effect (p≤0.05), increased functional activity of minor salivary glands (p≤0.05) promoting increased salivation and oral cavity cleansing. The concept of local recovery of the receptor apparatus of epithelial cells is confirmed for the first group of patients; the non-specific resistance in tobacco users is low, prevalence of Type I epithelial cells is defined (p≤0.05). CONCLUSION The evaluated toothpaste affects metabolism in the oral cavity because it was diagnosed that the non-specific resistance of the oral cavity and absorption by epithelia improved in all patients after the course use.