Optimization of magnetic forces for drug delivery in the inner ear

Abstract The inner ear is an important structure in the hearing system and in the balance sensibility for a human. The ear anatomy, especially the cochlea's, has a complex structure that makes disease treatment difficult. A liquid called perilymph is trapped in the cochlea by the Round Window Membrane (RWM). A leak of this liquid would result in a total loss of hearing which limits the possibility treatment by injecting drugs in the tympanic cavity, close to the RWM, to ensure that the maximum quantity of drugs is able to pass through it. The problem of this method is the side effects caused by drugs. The use of magnetic nanoparticles could be an alternative to massive drug delivery. This chapter aims to review the current knowledge concerning the RWM structure to define the best model, close to the real structure, to push magnetic particles through it.

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