Long‐lasting infiltration anaesthesia by lidocaine‐loaded biodegradable nanoparticles in hydrogel in rats

Background: Infiltration of a long‐lasting anaesthetic is helpful during the post‐operative period. The recently developed local drug delivery system, biodegradable nanoparticles in a thermo‐sensitive hydrogel (nanogel system), may possibly provide an extended duration of drugs. Therefore, we evaluated whether prolonged infiltration anaesthesia could be achieved by loading lidocaine into this delivery system.

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