Identification of psoralen, 8‐methoxypsoralen, isopimpinellin, and 5,7‐dimethoxycoumarin in Pelea anisata H. Mann

5.7‐dimethoxyeoumarin and isopimpinellin, together with the well‐known phototoxic, photo‐irritant furanocoumarins psoralen and 8‐methoxypsoralen, were isolated and identified from leaves and fruits of pelea anisata H. Mann, a plant whose fruit arc used in the construction of mohikana leis used in parts of the Hawaiian Islands, The presence of presence of phototoxic furanocoumarins would explain the occurrence of photodermatitis in the wearers of the leis.

[1]  Johnny Mitchell,et al.  Phytophotodermatitis from mokihana fruits (Pelea anisata H. Mann, fam. Rutaceae) in Hawaiian lei , 1984, Contact Dermatitis.

[2]  J. Raa,et al.  Phototoxicity from furocoumarins (psoralens) of Heracleum laciniatum in a patient with vitiligo. Action spectrum studies on bergapten, pimpinellin, angelicin and sphondin , 1983, Contact dermatitis.

[3]  M. Ashwood‐Smith,et al.  AN ULTRASENSITIVE BIOASSAY FOR THE DETECTION OF FUROCOUMARINS AND OTHER PHOTOSENSITIZING MOLECULES , 1983, Photochemistry and photobiology.

[4]  J. Metzger,et al.  Determination of a new scale of ortho-steric parameters S0 from N-methylation of pyridines , 1980 .

[5]  M. Ashwood‐Smith,et al.  5-Methoxypsoralen, an ingredient in several suntan preparations, has lethal, mutagenic and clastogenic properties , 1980, Nature.

[6]  P. Song,et al.  PHOTOCHEMISTRY AND PHOTOBIOLOGY OF PSORALENS , 1979, Photochemistry and photobiology.

[7]  W. Steck Leaf furanocoumarins of Heracleum lanatum , 1970 .

[8]  F. Daniels A SIMPLE MICROBIOLOGICAL METHOD FOR DEMONSTRATING PHOTOTOXIC COMPOUNDS. , 1965, The Journal of investigative dermatology.

[9]  R. Beier,et al.  Linear furocoumarins and other constituents from thamnosma texana , 1984 .

[10]  Stewart A. Brown,et al.  The natural coumarins : occurrence, chemistry, and biochemistry , 1982 .

[11]  D. Averbeck Photobiology of Furocoumarins , 1982 .

[12]  P. Scheuer,et al.  Hawaiian plant studies. Part XVI. Coumarins and flavones from Pelea barbigera(gray) hillebrand (rutaceae) , 1974 .

[13]  S. Carlquist,et al.  Hawaii, a natural history , 1970 .