Simultaneous determination of arsenic, manganese and selenium in human serum by neutron activation analysis

A procedure for the simultaneous determination of arsenic, manga nese, and selenium in human serum is described, and its performance characteristics are evaluated with particular reference to manganese. Blank values depend critically on irradiation containers, and only one type of poly ethylene ampoule gave a sufficiently low limit of detection. Other suspected sources of random and systematic errors are investigated; they did not, however, jeopardize precision or accuracy of analytical results. Careful studies of the sampling techniques with actual as well as simulated serum revealed considerable contamination with arsenic and manganese under normal hospital conditions; in addition, loss of added dimetbylselenide was observed even during deep-freeze storage of serum. A detailed sampling procedure with special precautions against contamination is described, and is shown to yield meaningful results for normal, human serum. Results tend to agree with the lowest values reported in the literature, and the ana lytical precision is sufficient for determination of the standard deviation of the distribution of all 3 elements in human serum. * work 2nd on the Recent Developments in Neutron Activation Analysis, Cambridge, 1971

[1]  E. Damsgaard,et al.  Simultaneous determination of arsenic, copper, manganese, selenium, and zinc in biological materials by neutron activation analysis. , 1976, Riso report.

[2]  K. Norgard,et al.  Analysis of precision of activation-analysis methods. , 1973, Talanta.

[3]  J. Heinonen,et al.  Reliability of neutron activation analysis for trace elements in biological materials. , 1973 .

[4]  H. Pakkenberg,et al.  Neutron activation analysis of arsenic, manganese, and selenium concentrations in organs of uraemic and normal persons. , 1973 .

[5]  D. Behne,et al.  Relations between carbohydrate and trace-element metabolisms investigated by neutron activation analysis. , 1973 .

[6]  D. Comar,et al.  Possibilites et limites de l'analyse par activation neutronique multielementaire d'echantillons biologiques avec ou sans separation de la matrice activable , 1973 .

[7]  E. Damsgaard,et al.  Simultaneous determination of arsenic, manganese, and selenium in biological materials by neutron-activation analysis. , 1973, Talanta.

[8]  H. S. Olcott,et al.  Selenium determination in human serum lipoprotein fractions by neutron activation analysis. , 1972, Analytical biochemistry.

[9]  S. Saltzstein,et al.  The vitamin E and selenium status of infants and the sudden infant death syndrome , 1972 .

[10]  Arsagova Ns.  The concentration of nickel and manganese in patients with cancer of the uterus , 1971 .

[11]  R. Olson,et al.  Blood Selenium in Thai Children with Protein-Calorie Malnutrition 1 , 1970, Proceedings of the Society for Experimental Biology and Medicine. Society for Experimental Biology and Medicine.

[12]  K. Heydorn.  Environmental variation of arsenic levels in human blood determines by neutron activation analysis. , 1970, Clinica chimica acta; international journal of clinical chemistry.

[13]  L. Lesca,et al.  THRESHOLD REACTION EXCITATION FUNCTIONS INTERCALIBRATED IN A PURE FISSION SPECTURM. , 1970 .

[14]  V. I. Drynkin,et al.  HANDBOOK OF NUCLEAR DATA FROM NEUTRON ACTIVATION ANALYSIS. , 1970 .

[15]  F. Graber,et al.  NEUTRON ACTIVATION ANALYSIS OF BIOLOGICAL MATERIALS. , 1969 .

[16]  Lloyd A. Currie,et al.  Limits for qualitative detection and quantitative determination , 1968 .

[17]  R. C. Dickson,et al.  Selenium in blood and human tissues. , 1967, Clinica chimica acta; international journal of clinical chemistry.

[18]  E. Kanabrocki,et al.  Non-dialyzable manganese and copper levels in serum of patients with various diseases. , 1967, Journal of nuclear medicine : official publication, Society of Nuclear Medicine.

[19]  R. Schmitt,et al.  Neutron activation analysis of magnesium, calcium, strontium, barium, manganese, cobalt, copper, zinc, sodium, and potassium in human erythrocytes and plasma. , 1966, Journal of nuclear medicine : official publication, Society of Nuclear Medicine.

[20]  S. Miller,et al.  Neutron activation analysis: the stability of manganese concentrations in human blood and serum. , 1966, Journal of Laboratory and Clinical Medicine.

[21]  J. Gofman,et al.  CHEMICAL ELEMENTS OF THE BLOOD OF MAN. , 1964, Archives of environmental health.

[22]  H. S. Satterlee,et al.  Ultramicrodetermination of Arsenic by Gutzeit Spot-Filtration under Vacuum. A Rapid Technique Employing Photometric Calibration and Permanent Photographic Standards , 1944 .