Antisense oligonucleotides as therapeutic agents--is the bullet really magical?
暂无分享,去创建一个
Y. Cheng | C. Stein | C. Stein | Yung‐chi Cheng | Y. Cheng
[1] D. P. Jackson,et al. Labyrinthine Pattern Formation in Magnetic Fluids , 1993, Science.
[2] S. Rotenberg,et al. Dynamics of the internalization of phosphodiester oligodeoxynucleotides in HL60 cells. , 1993, Biochemistry.
[3] J. Lisziewicz,et al. Long-term treatment of human immunodeficiency virus-infected cells with antisense oligonucleotide phosphorothioates. , 1993, Proceedings of the National Academy of Sciences of the United States of America.
[4] G. Sczakiel,et al. In vitro selection of fast-hybridizing and effective antisense RNAs directed against the human immunodeficiency virus type 1. , 1993, Nucleic acids research.
[5] Qiuyan Zhao,et al. Modification of antisense phosphodiester oligodeoxynucleotides by a 5' cholesteryl moiety increases cellular association and improves efficacy. , 1993, Proceedings of the National Academy of Sciences of the United States of America.
[6] M. Nerenberg,et al. Ablation of transplanted HTLV-I tax-transformed tumors in mice by antisense inhibition of NF-kappa B. , 1992, Science.
[7] Y. Cheng,et al. Cellular pharmacology of phosphorothioate homooligodeoxynucleotides in human cells. , 1993, Molecular pharmacology.
[8] M. Nerenberg,et al. Human T-cell leukemia virus type I tax transformation is associated with increased uptake of oligodeoxynucleotides in vitro and in vivo. , 1992, The Journal of biological chemistry.
[9] G. Zon,et al. In vivo treatment of human leukemia in a scid mouse model with c-myb antisense oligodeoxynucleotides. , 1992, Proceedings of the National Academy of Sciences of the United States of America.
[10] E. Wickstrom,et al. Down-regulation of c-MYC antigen expression in lymphocytes of Emu-c-myc transgenic mice treated with anti-c-myc DNA methylphosphonates. , 1992, Cancer research.
[11] D. Ecker,et al. Implication of RNA structure on antisense oligonucleotide hybridization kinetics. , 1992, Biochemistry.
[12] C. Roberts,et al. The growth-stimulatory effect of simian virus 40 T antigen requires the interaction of insulinlike growth factor 1 with its receptor , 1992, Molecular and cellular biology.
[13] S. Ferrari,et al. Antisense Strategies to Characterize the Role of Genes and Oncogenes Involved in Myeloid Differentiation a , 1992, Annals of the New York Academy of Sciences.
[14] Michael Simons,et al. Antisense c-myb oligonucleotides inhibit intimal arterial smooth muscle cell accumulation in vivo , 1992, Nature.
[15] D. Melton,et al. Specificity of antisense oligonucleotides in vivo. , 1992, Proceedings of the National Academy of Sciences of the United States of America.
[16] I. D'Agnano,et al. Inhibition of leukemia cell proliferation by receptor-mediated uptake of c-myb antisense oligodeoxynucleotides. , 1992, Proceedings of the National Academy of Sciences of the United States of America.
[17] D. Green,et al. Role for c-myc in activation-induced apoptotic cell death in T cell hybridomas. , 1992, Science.
[18] E. Kuramoto,et al. Unique palindromic sequences in synthetic oligonucleotides are required to induce IFN [correction of INF] and augment IFN-mediated [correction of INF] natural killer activity. , 1992, Journal of immunology.
[19] C. Bennett,et al. Cationic lipids enhance cellular uptake and activity of phosphorothioate antisense oligonucleotides. , 1992, Molecular pharmacology.
[20] L B Schook,et al. Tumor necrosis factor alpha is an autocrine growth regulator during macrophage differentiation. , 1992, Proceedings of the National Academy of Sciences of the United States of America.
[21] A. Mantovani,et al. B-myb antisense oligonucleotides inhibit proliferation of human hematopoietic cell lines. , 1992, Blood.
[22] B. Vogelstein,et al. Antisense RNA to the putative tumor-suppressor gene DCC transforms Rat-1 fibroblasts. , 1992, Oncogene.
[23] B. Calabretta,et al. Growth factor-dependent inhibition of normal hematopoiesis by N-ras antisense oligodeoxynucleotides , 1992, The Journal of experimental medicine.
[24] A. Harel-Bellan,et al. A triple helix-forming oligonucleotide-intercalator conjugate acts as a transcriptional repressor via inhibition of NF kappa B binding to interleukin-2 receptor alpha-regulatory sequence. , 1992, The Journal of biological chemistry.
[25] Y. Cheng,et al. Phosphorothioate oligonucleotides are inhibitors of human DNA polymerases and RNase H: implications for antisense technology. , 1992, Molecular pharmacology.
[26] W. Paul,et al. An antisense oligonucleotide complementary to a sequence in I gamma 2b increases gamma 2b germline transcripts, stimulates B cell DNA synthesis, and inhibits immunoglobulin secretion , 1992, The Journal of experimental medicine.
[27] H. Soreq,et al. Cloning and antisense oligodeoxynucleotide inhibition of a human homolog of cdc2 required in hematopoiesis. , 1992, Proceedings of the National Academy of Sciences of the United States of America.
[28] S. Crooke. Therapeutic applications of oligonucleotides. , 1992, Bio/technology.
[29] J. Jaroszewski,et al. A comparison of gag, pol and rev antisense oligodeoxynucleotides as inhibitors of HIV-1. , 1992, Antiviral research.
[30] M. Watabe,et al. Binding of oligonucleotides to cell membranes at acidic pH. , 1991, Biochemical and biophysical research communications.
[31] M. Egholm,et al. Sequence-selective recognition of DNA by strand displacement with a thymine-substituted polyamide. , 1991, Science.
[32] A. Brussaard,et al. Functional contribution of neuronal AChR subunits revealed by antisense oligonucleotides. , 1991, Science.
[33] R. Pepperkok,et al. Cell growth stimulation by EGF: inhibition through antisense-oligodeoxynucleotides demonstrates important role of casein kinase II. , 1991, Experimental cell research.
[34] L. Neyses,et al. Inhibition of endothelin-1 induced myocardial protein synthesis by an antisense oligonucleotide against the early growth response gene-1. , 1991, Biochemical and biophysical research communications.
[35] W. Stec,et al. Novel route to oligo(deoxyribonucleoside phosphorothioates). Stereocontrolled synthesis of P-chiral oligo(deoxyribonucleoside phosphorothioates). , 1991, Nucleic Acids Research.
[36] O. Hermine,et al. An autocrine role for erythropoietin in mouse hematopoietic cell differentiation. , 1991, Blood.
[37] R. Hromas,et al. Antisense oligonucleotides from the stage-specific myeloid zinc finger gene MZF-1 inhibit granulopoiesis in vitro , 1991, The Journal of experimental medicine.
[38] A. Periasamy,et al. Mechanism of cellular uptake of modified oligodeoxynucleotides containing methylphosphonate linkages. , 1991, Nucleic acids research.
[39] M. Saarma,et al. Dependence of kidney morphogenesis on the expression of nerve growth factor receptor. , 1991, Science.
[40] E. Kollar,et al. EGF antisense oligodeoxynucleotides block murine odontogenesis in vitro. , 1991, Developmental biology.
[41] J. Hatzfeld,et al. Release of early human hematopoietic progenitors from quiescence by antisense transforming growth factor beta 1 or Rb oligonucleotides , 1991, The Journal of experimental medicine.
[42] S. Freier,et al. Antisense oligonucleotides inhibit intercellular adhesion molecule 1 expression by two distinct mechanisms. , 1991, The Journal of biological chemistry.
[43] S. J. Flint,et al. Evidence that a triplex-forming oligodeoxyribonucleotide binds to the c-myc promoter in HeLa cells, thereby reducing c-myc mRNA levels. , 1991, Proceedings of the National Academy of Sciences of the United States of America.
[44] T. V. Berkel,et al. Association of antisense oligonucleotides with lipoproteins prolongs the plasma half-life and modifies the tissue distribution , 1991 .
[45] J. Blalock,et al. Antisense oligodeoxynucleotide to the cystic fibrosis gene inhibits anion transport in normal cultured sweat duct cells. , 1991, Proceedings of the National Academy of Sciences of the United States of America.
[46] S. Agrawal,et al. Pharmacokinetics, biodistribution, and stability of oligodeoxynucleotide phosphorothioates in mice. , 1991, Proceedings of the National Academy of Sciences of the United States of America.
[47] E. Chang,et al. Antisense inhibition of ras p21 expression that is sensitive to a point mutation. , 1991, Biochemistry.
[48] A. West,et al. A novel method to modulate desensitization and truncation of luteinizing hormone receptors using antisense oligodeoxynucleotides , 1991, Molecular and Cellular Endocrinology.
[49] B. Cullen,et al. Identification of the envelope V3 loop as the primary determinant of cell tropism in HIV-1. , 1991, Science.
[50] P. D. Cook,et al. Inhibition of HIV-LTR gene expression by oligonucleotides targeted to the TAR element. , 1991, Nucleic acids research.
[51] B. Hirschbein,et al. Internucleotide phosphite sulfurization with tetraethylthiuram disulfide. Phosphorothioate oligonucleotide synthesis via phosphoramidite chemistry , 1991 .
[52] S. Crooke,et al. Cloning of a phospholipase A2-activating protein. , 1991, Proceedings of the National Academy of Sciences of the United States of America.
[53] K. Kosik,et al. The effect of tau antisense oligonucleotides on neurite formation of cultured cerebellar macroneurons , 1991, The Journal of neuroscience : the official journal of the Society for Neuroscience.
[54] B. Tocqué,et al. Short modified antisense oligonucleotides directed against Ha‐ras point mutation induce selective cleavage of the mRNA and inhibit T24 cells proliferation. , 1991, The EMBO journal.
[55] J. Blalock,et al. An antisense oligodeoxynucleotide to growth hormone messenger ribonucleic acid inhibits lymphocyte proliferation. , 1991, Endocrinology.
[56] R. Letsinger,et al. Mode of action of 5'-linked cholesteryl phosphorothioate oligodeoxynucleotides in inhibiting syncytia formation and infection by HIV-1 and HIV-2 in vitro. , 1991, Biochemistry.
[57] D. L. Weeks,et al. Epithelial-mesenchymal transformation of embryonic cardiac endothelial cells is inhibited by a modified antisense oligodeoxynucleotide to transforming growth factor beta 3. , 1991, Proceedings of the National Academy of Sciences of the United States of America.
[58] R. Morrison. Suppression of basic fibroblast growth factor expression by antisense oligodeoxynucleotides inhibits the growth of transformed human astrocytes. , 1991, The Journal of biological chemistry.
[59] E. Wickstrom,et al. Walking along human c-myc mRNA with antisense oligodeoxynucleotides: maximum efficacy at the 5' cap region. , 1991, Oncogene research.
[60] J. Bag,et al. Alterations in the expression of muscle-specific genes mediated by troponin C antisense oligodeoxynucleotide. , 1991, Experimental cell research.
[61] J. Walder,et al. Substrate specificity and kinetics of degradation of antisense oligonucleotides by a 3' exonuclease in plasma. , 1991, Antisense research and development.
[62] Y. Cheng,et al. Mechanisms of inhibition of herpes simplex virus type 2 growth by 28-mer phosphorothioate oligodeoxycytidine. , 1990, The Journal of biological chemistry.
[63] F. Ruscetti,et al. Inhibition of murine monocyte proliferation by a colony-stimulating factor-1 antisense oligodeoxynucleotide. Evidence for autocrine regulation. , 1990, Journal of immunology.
[64] H. Piwnica-Worms,et al. cdc2 gene expression at the G1 to S transition in human T lymphocytes. , 1990, Science.
[65] T. Tsuruo,et al. Modulation of multidrug resistance by verapamil or mdr1 anti‐sense oligodeoxynucleotide does not change the high susceptibility to lymphokine‐activated killers in mdr‐resistant human carcinoma (LoVo) line , 1990, International journal of cancer.
[66] L. V. Van Eldik,et al. Use of DNA sequence and mutant analyses and antisense oligodeoxynucleotides to examine the molecular basis of nonmuscle myosin light chain kinase autoinhibition, calmodulin recognition, and activity , 1990, The Journal of cell biology.
[67] J. Florini,et al. Highly specific inhibition of IGF-I-stimulated differentiation by an antisense oligodeoxyribonucleotide to myogenin mRNA. No effects on other actions of IGF-T. , 1990, The Journal of biological chemistry.
[68] W. Stec,et al. Preparation of 35S-labeled polyphosphorothioate oligodeoxyribonucleotides by use of hydrogen phosphonate chemistry. , 1990, Analytical biochemistry.
[69] J. Toulmé,et al. Specific regulation of gene expression by antisense, sense and antigene nucleic acids. , 1990, Biochimica et biophysica acta.
[70] K. Han,et al. The role of the c-fms oncogene in the regulation of HL-60 cell differentiation. , 1990, Oncogene.
[71] Y. Cheng,et al. Inhibition of herpes simplex virus type 2 growth by phosphorothioate oligodeoxynucleotides , 1990, Antimicrobial Agents and Chemotherapy.
[72] P. Zamecnik,et al. Inhibition of influenza virus replication by phosphorothioate oligodeoxynucleotides. , 1990, Proceedings of the National Academy of Sciences of the United States of America.
[73] S. Beaucage,et al. 3H-1,2-Benzodithiole-3-one 1,1-dioxide as an improved sulfurizing reagent in the solid-phase synthesis of oligodeoxyribonucleoside phosphorothioates , 1990 .
[74] Z. Darżynkiewicz,et al. Down-regulation of a serine protease, myeloblastin, causes growth arrest and differentiation of promyelocytic leukemia cells , 1989, Cell.
[75] J. Toulmé,et al. Phosphoroselenoate oligodeoxynucleotides: synthesis, physico-chemical characterization, anti-sense inhibitory properties and anti-HIV activity. , 1989, Nucleic acids research.
[76] J. Maizel,et al. Inhibition of human immunodeficiency virus in early infected and chronically infected cells by antisense oligodeoxynucleotides and their phosphorothioate analogues. , 1989, Proceedings of the National Academy of Sciences of the United States of America.
[77] R. Letsinger,et al. Cholesteryl-conjugated oligonucleotides: synthesis, properties, and activity as inhibitors of replication of human immunodeficiency virus in cell culture. , 1989, Proceedings of the National Academy of Sciences of the United States of America.
[78] V. Vlassov,et al. Mechanism of oligonucleotide uptake by cells: involvement of specific receptors? , 1989, Proceedings of the National Academy of Sciences of the United States of America.
[79] V. Vlassov,et al. Synthesis of alkylating oligonucleotide derivatives containing cholesterol or phenazinium residues at their 3′‐terminus and their interaction with DNA within mammalian cells , 1989, FEBS letters.
[80] S. Lederman,et al. Dextran sulfate and heparin interact with CD4 molecules to inhibit the binding of coat protein (gp120) of HIV. , 1989, Journal of immunology.
[81] Y. Cheng,et al. Effect of phosphorothioate homo-oligodeoxynucleotides on herpes simplex virus type 2-induced DNA polymerase. , 1989, The Journal of biological chemistry.
[82] F. Cope,et al. Retinoid receptor antisense DNAs inhibit alkaline phosphatase induction and clonogenicity in malignant keratinocytes. , 1989, Proceedings of the National Academy of Sciences of the United States of America.
[83] J. Toulmé,et al. Comparative inhibition of rabbit globin mRNA translation by modified antisense oligodeoxynucleotides. , 1989, Nucleic acids research.
[84] H. Mitsuya,et al. Regulation of viral expression of human immunodeficiency virus in vitro by an antisense phosphorothioate oligodeoxynucleotide against rev (art/trs) in chronically infected cells. , 1989, Proceedings of the National Academy of Sciences of the United States of America.
[85] P. Sperryn,et al. Blood. , 1989, British journal of sports medicine.
[86] L. Neckers,et al. Characterization of oligonucleotide transport into living cells. , 1989, Proceedings of the National Academy of Sciences of the United States of America.
[87] E. De Clercq,et al. Specific interaction of aurintricarboxylic acid with the human immunodeficiency virus/CD4 cell receptor. , 1989, Proceedings of the National Academy of Sciences of the United States of America.
[88] J. S. Lee,et al. Synthetic repeating sequence DNAs containing phosphorothioates: nuclease sensitivity and triplex formation. , 1989, Nucleic acids research.
[89] S. Broder,et al. Stepwise mechanism of HIV reverse transcriptase: primer function of phosphorothioate oligodeoxynucleotide. , 1989, Biochemistry.
[90] L. Neckers,et al. Phosphorothioate and normal oligodeoxyribonucleotides with 5'-linked acridine: characterization and preliminary kinetics of cellular uptake. , 1988, Gene.
[91] J. Toulmé,et al. Antimessenger oligodeoxyribonucleotides: an alternative to antisense RNA for artificial regulation of gene expression--a review. , 1988, Gene.
[92] U. Littauer,et al. The inhibition of neurite outgrowth in PC12 cells by tubulin antisense oligodeoxyribonucleotides. , 1988, Gene.
[93] P. Zamecnik,et al. Oligodeoxynucleoside phosphoramidates and phosphorothioates as inhibitors of human immunodeficiency virus. , 1988, Proceedings of the National Academy of Sciences of the United States of America.
[94] E. De Clercq,et al. Pentosan polysulfate, a sulfated oligosaccharide, is a potent and selective anti-HIV agent in vitro. , 1988, Antiviral research.
[95] S. J. Flint,et al. Site-specific oligonucleotide binding represses transcription of the human c-myc gene in vitro. , 1988, Science.
[96] J. Walder,et al. Role of RNase H in hybrid-arrested translation by antisense oligonucleotides. , 1988, Proceedings of the National Academy of Sciences of the United States of America.
[97] A. Fields,et al. Human immunodeficiency virus induces phosphorylation of its cell surface receptor , 1988, Nature.
[98] C. Stein,et al. Oligodeoxynucleotides as inhibitors of gene expression: a review. , 1988, Cancer research.
[99] K. Shinozuka,et al. Physicochemical properties of phosphorothioate oligodeoxynucleotides. , 1988, Nucleic acids research.
[100] E R Kandel,et al. Selective elimination of mRNAs in vivo: complementary oligodeoxynucleotides promote RNA degradation by an RNase H-like activity. , 1987, Proceedings of the National Academy of Sciences of the United States of America.
[101] M. Reitz,et al. Phosphorothioate analogs of oligodeoxynucleotides: inhibitors of replication and cytopathic effects of human immunodeficiency virus. , 1987, Proceedings of the National Academy of Sciences of the United States of America.
[102] W. Stec,et al. Phosphorothioate-modified oligodeoxyribonucleotides. III. NMR and UV spectroscopic studies of the Rp-Rp, Sp-Sp, and Rp-Sp duplexes, [d(GGSAATTCC)]2, derived from diastereomeric O-ethyl phosphorothioates. , 1986, Nucleic acids research.
[103] Brian C. Froehler,et al. Synthesis of DNA via deoxynucleoside H-phosphonate intermediates , 1986, Nucleic Acids Res..
[104] J. Sodroski,et al. A second post-transcriptional trans-activator gene required for HTLV-III replication , 1986, Nature.
[105] R. Bennett,et al. DNA binding to human leukocytes. Evidence for a receptor-mediated association, internalization, and degradation of DNA. , 1985, The Journal of clinical investigation.
[106] F. Eckstein,et al. Synthesis of d(GC) and d(CG) octamers containing alternating phosphorothioate linkages: effect of the phosphorothioate group on the B-Z transition. , 1985, Biochemistry.
[107] W. Stec,et al. Automated solid-phase synthesis, separation, and stereochemistry of phosphorothioate analogs of oligodeoxyribonucleotides , 1984 .
[108] K. Hagino-Yamagishi,et al. [Oncogene]. , 2019, Gan to kagaku ryoho. Cancer & chemotherapy.
[109] B. Potter,et al. Stereochemical course of DNA hydrolysis by nuclease S1. , 1983, The Journal of biological chemistry.
[110] S. Benkovic,et al. Stereochemical course of the reaction catalyzed by 5'-nucleotide phosphodiesterase from snake venom. , 1979, Biochemistry.
[111] J. M. Oshorn. Proc. Nat. Acad. Sei , 1978 .