Instrumental requirements for blood glucose sensing based on diffuse reflectance NIR spectroscopy

The study on the magnitude of spectral change in blood glucose measurements with diffuse reflectance NIR spectroscopy is presented. Spectral change is estimated by a Monte Carlo simulation and measurements of absorbance spectra of aqueous glucose solution. Required sensitivity of spectrophotometers for monitoring the changein the blood glucose concentration as small as 10mg/dL has been obtained using the estimated change in the absorbance spectrum and mean pathlength of light in tissue.

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