NLRP4 negatively regulates type I interferon signaling by targeting the kinase TBK1 for degradation via the ubiquitin ligase DTX4

[1]  Yong‐jun Liu,et al.  The helicase DDX41 senses intracellular DNA mediated by the adaptor STING in dendritic cells , 2011, Nature Immunology.

[2]  Y. Kong,et al.  Mapping a dynamic innate immunity protein interaction network regulating type I interferon production. , 2011, Immunity.

[3]  Z. Elazar,et al.  TBK1 Mediates Crosstalk Between the Innate Immune Response and Autophagy , 2011, Science Signaling.

[4]  Zhijian J. Chen,et al.  NLRX1 negatively regulates TLR-induced NF-κB signaling by targeting TRAF6 and IKK. , 2011, Immunity.

[5]  M. White,et al.  TBK1 directly engages Akt/PKB survival signaling to support oncogenic transformation. , 2011, Molecular cell.

[6]  K. Ishii,et al.  NLRP4 Negatively Regulates Autophagic Processes through an Association with Beclin1 , 2011, The Journal of Immunology.

[7]  H. Shu,et al.  Glycogen synthase kinase 3β regulates IRF3 transcription factor-mediated antiviral response via activation of the kinase TBK1. , 2010, Immunity.

[8]  A. Bowie,et al.  IFI16 is an innate immune sensor for intracellular DNA , 2010, Nature Immunology.

[9]  D. Philpott,et al.  NLRC5 Limits the Activation of Inflammatory Pathways , 2010, The Journal of Immunology.

[10]  Zhijian J. Chen,et al.  NLRC5 Negatively Regulates the NF-κB and Type I Interferon Signaling Pathways , 2010, Cell.

[11]  S. Akira,et al.  Pattern Recognition Receptors and Inflammation , 2010, Cell.

[12]  V. Vacic,et al.  Identification, analysis, and prediction of protein ubiquitination sites , 2010, Proteins.

[13]  F. You,et al.  PCBP2 mediates degradation of the adaptor MAVS via the HECT ubiquitin ligase AIP4 , 2009, Nature Immunology.

[14]  S. Bloor,et al.  The TBK1 adaptor and autophagy receptor NDP52 restricts the proliferation of ubiquitin-coated bacteria , 2009, Nature Immunology.

[15]  D. Feldser,et al.  Requirement for NF-κB signalling in a mouse model of lung adenocarcinoma , 2009, Nature.

[16]  Ben S. Wittner,et al.  Systematic RNA interference reveals that oncogenic KRAS-driven cancers require TBK1 , 2009, Nature.

[17]  Zhijian J. Chen,et al.  RNA Polymerase III Detects Cytosolic DNA and Induces Type I Interferons through the RIG-I Pathway , 2009, Cell.

[18]  V. Hornung,et al.  RIG-I-dependent sensing of poly(dA:dT) through the induction of an RNA polymerase III–transcribed RNA intermediate , 2009, Nature Immunology.

[19]  Nan Li,et al.  The E3 ubiquitin ligase Nrdp1 'preferentially' promotes TLR-mediated production of type I interferon , 2009, Nature Immunology.

[20]  L. O’Neill.  When signaling pathways collide: positive and negative regulation of toll-like receptor signal transduction. , 2008, Immunity.

[21]  J. Gatot,et al.  Are the IKKs and IKK-related kinases TBK1 and IKK-epsilon similarly activated? , 2008, Trends in biochemical sciences.

[22]  D. Philpott,et al.  NLRX1 is a mitochondrial NOD‐like receptor that amplifies NF‐κB and JNK pathways by inducing reactive oxygen species production , 2008, EMBO reports.

[23]  M. Heise,et al.  NLRX1 is a regulator of mitochondrial antiviral immunity , 2008, Nature.

[24]  F. Randow,et al.  SINTBAD, a novel component of innate antiviral immunity, shares a TBK1‐binding domain with NAP1 and TANK , 2007, The EMBO journal.

[25]  K. Honda,et al.  IRFs: master regulators of signalling by Toll-like receptors and cytosolic pattern-recognition receptors , 2006, Nature Reviews Immunology.

[26]  Yu Xue,et al.  PPSP: prediction of PK-specific phosphorylation site with Bayesian decision theory , 2006, BMC Bioinformatics.

[27]  V. Nizet,et al.  Innate Immunity Gone Awry: Linking Microbial Infections to Chronic Inflammation and Cancer , 2006, Cell.

[28]  F. Liew,et al.  Negative regulation of Toll-like receptor-mediated immune responses , 2005, Nature Reviews Immunology.

[29]  K. Honda,et al.  Spatiotemporal regulation of MyD88–IRF-7 signalling for robust type-I interferon induction , 2005, Nature.

[30]  A. Godzik,et al.  A Novel PAAD-containing Protein That Modulates NF-κB Induction by Cytokines Tumor Necrosis Factor-α and Interleukin-1β* , 2002, The Journal of Biological Chemistry.

[31]  J. Tschopp,et al.  The Inflammasomes , 2010, Cell.

[32]  T. Maniatis,et al.  IKKepsilon and TBK1 are essential components of the IRF3 signaling pathway. , 2003, Nature immunology.

[33]  A. Godzik,et al.  A novel PAAD-containing protein that modulates NF-kappa B induction by cytokines tumor necrosis factor-alpha and interleukin-1beta. , 2002, The Journal of biological chemistry.