Lensfree super-resolved microscopy based on multi-wavelength multiplexing

In this paper, we present a multi-wavelength multiplexed setup and associated super-resolution reconstruction method in lensfree microscopy that generates high-resolution reconstructions from undersampled raw measurements captured at multiple wavelengths. The reconstruction result of the standard 1951 USAF achieves a half-pitch lateral resolution of 775 nm, corresponding to a numerical aperture of 1.0, across a large field of view (∼ 29.85 mm2). Compared with other super-resolution methods such as lateral or axial shift-based device and illumination source rotation design, wavelength multiplexed avoids the need for shifting/rotating mechanical components. This multi-wavelength multiplexed super-resolution method would benefit the research and development of a more stable lensfree microscopy system.

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