The crystal structure of the proprotein processing proteinase furin explains its stringent specificity

[1]  An Zhou,et al.  Mutational analysis of predicted interactions between the catalytic and P domains of prohormone convertase 3 (PC3/PC1) , 2003, Proceedings of the National Academy of Sciences of the United States of America.

[2]  I. Lindberg,et al.  The Furin Inhibitor Hexa-d-Arginine Blocks the Activation of Pseudomonas aeruginosa Exotoxin A In Vivo , 2002, Infection and Immunity.

[3]  T. Komiyama,et al.  Precursor processing by kex2/furin proteases. , 2002, Chemical reviews.

[4]  G. Thomas,et al.  Furin at the cutting edge: From protein traffic to embryogenesis and disease , 2002, Nature Reviews Molecular Cell Biology.

[5]  J. Orban,et al.  Solution Structure of the Mouse Prohormone Convertase 1 Pro-Domain , 2002 .

[6]  G. Thomas,et al.  The Ordered and Compartment-specific Autoproteolytic Removal of the Furin Intramolecular Chaperone Is Required for Enzyme Activation* , 2002, The Journal of Biological Chemistry.

[7]  R. Leduc,et al.  Inhibitory Potency and Specificity of Subtilase-like Pro-protein Convertase (SPC) Prodomains* , 2002, The Journal of Biological Chemistry.

[8]  N. Seidah,et al.  pH‐induced conformational transitions of a molten–globule–like state of the inhibitory prodomain of furin: Implications for zymogen activation , 2001, Protein science : a publication of the Protein Society.

[9]  N. Seidah,et al.  Implication of the proprotein convertases furin, PC5 and PC7 in the cleavage of surface glycoproteins of Hong Kong, Ebola and respiratory syncytial viruses: a comparative analysis with fluorogenic peptides. , 2001, The Biochemical journal.

[10]  I. Lindberg,et al.  Polyarginines Are Potent Furin Inhibitors* , 2000, The Journal of Biological Chemistry.

[11]  T. Soulimane,et al.  A novel free-mounting system for protein crystals: transformation and improvement of diffraction power by accurately controlled humidity changes , 2000 .

[12]  N. Seidah,et al.  Proprotein and prohormone convertases: a family of subtilases generating diverse bioactive polypeptides 1 Published on the World Wide Web on 17 August 1999. 1 , 1999, Brain Research.

[13]  R M Esnouf,et al.  Further additions to MolScript version 1.4, including reading and contouring of electron-density maps. , 1999, Acta crystallographica. Section D, Biological crystallography.

[14]  D. Constam,et al.  Failure of ventral closure and axial rotation in embryos lacking the proprotein convertase Furin. , 1998, Development.

[15]  R J Read,et al.  Crystallography & NMR system: A new software suite for macromolecular structure determination. , 1998, Acta crystallographica. Section D, Biological crystallography.

[16]  H. Feldmann,et al.  Processing of the Ebola virus glycoprotein by the proprotein convertase furin. , 1998, Proceedings of the National Academy of Sciences of the United States of America.

[17]  An Zhou,et al.  Regulatory Roles of the P Domain of the Subtilisin-like Prohormone Convertases* , 1998, The Journal of Biological Chemistry.

[18]  N. Seidah,et al.  Proprotein Convertases , 2011, Methods in Molecular Biology.

[19]  K Nakayama,et al.  Furin: a mammalian subtilisin/Kex2p-like endoprotease involved in processing of a wide variety of precursor proteins. , 1997, The Biochemical journal.

[20]  N. Seidah,et al.  The integrity of the RRGDL sequence of the proprotein convertase PC1 is critical for its zymogen and C-terminal processing and for its cellular trafficking. , 1997, The Biochemical journal.

[21]  J. Vanslyke,et al.  Activation of the furin endoprotease is a multiple‐step process: requirements for acidification and internal propeptide cleavage , 1997, The EMBO journal.

[22]  J. Leunissen,et al.  Subtilases: The superfamily of subtilisin‐like serine proteases , 1997, Protein science : a publication of the Protein Society.

[23]  E A Merritt,et al.  Raster3D: photorealistic molecular graphics. , 1997, Methods in enzymology.

[24]  P. Bryan,et al.  The prosegment-subtilisin BPN' complex: crystal structure of a specific 'foldase'. , 1995, Structure.

[25]  N. Seidah,et al.  Fluorescent Peptidyl Substrates as an Aid in Studying the Substrate Specificity of Human Prohormone Convertase PC1 and Human Furin and Designing a Potent Irreversible Inhibitor (*) , 1995, The Journal of Biological Chemistry.

[26]  R. Siezen,et al.  Homology modelling of the catalytic domain of human furin. A model for the eukaryotic subtilisin-like proprotein convertases. , 1994, European journal of biochemistry.

[27]  G J Barton,et al.  ALSCRIPT: a tool to format multiple sequence alignments. , 1993, Protein engineering.

[28]  H. Klenk,et al.  Inhibition of furin-mediated cleavage activation of HIV-1 glycoprotein gpl60 , 1992, Nature.

[29]  K. Klimpel,et al.  Human furin is a calcium-dependent serine endoprotease that recognizes the sequence Arg-X-X-Arg and efficiently cleaves anthrax toxin protective antigen. , 1992, The Journal of biological chemistry.

[30]  P. Kraulis A program to produce both detailed and schematic plots of protein structures , 1991 .

[31]  J. Thorner,et al.  Intracellular targeting and structural conservation of a prohormone-processing endoprotease. , 1989, Science.

[32]  Djordje Musil,et al.  The high-resolution X-ray crystal structure of the complex formed between subtilisin Carlsberg and eglin c, an elastase inhibitor from the leech Hirudo medicinalis Structural analysis, subtilisin structure and interface geometry , 1987 .