Revealing the Underlying Mechanism of Acacia Nilotica against Asthma from a Systematic Perspective: A Network Pharmacology and Molecular Docking Study

Acacia Nilotica (AN) has long been used as a folk cure for asthma, but little is known about how AN could possibly modulate this disease. Thus, an in-silico molecular mechanism for AN’s anti-asthmatic action was elucidated utilizing network pharmacology and molecular docking techniques. DPED, PubChem, Binding DB, DisGeNET, DAVID, and STRING were a few databases used to collect network data. MOE 2015.10 software was used for molecular docking. Out of 51 searched compounds of AN, eighteen compounds interacted with human target genes, a total of 189 compounds-related genes, and 2096 asthma-related genes were found in public databases, with 80 overlapping genes between them. AKT1, EGFR, VEGFA, and HSP90AB were the hub genes, whereas quercetin and apigenin were the most active components. p13AKT and MAPK signaling pathways were found to be the primary target of AN. Outcomes of network pharmacology and molecular docking predicted that AN might exert its anti-asthmatic effect probably by altering the p13AKT and MAPK signaling pathway.

[1]  Sami I. Alzarea,et al.  Anandamide Reuptake Inhibitor (VDM11) as a Possible Candidate for COVID-19 Associated Depression; a Combination of Network Pharmacology, Molecular Docking and In Vivo Experimental Analysis , 2023, Processes.

[2]  Sami I. Alzarea,et al.  Network Pharmacology and Molecular Docking Based Prediction of Mechanism of Pharmacological Attributes of Glutinol , 2022, Processes.

[3]  H. AbdElgawad,et al.  Integrating Network Pharmacology and Molecular Docking Approaches to Decipher the Multi-Target Pharmacological Mechanism of Abrus precatorius L. Acting on Diabetes , 2022, Pharmaceuticals.

[4]  Yan-Li Mao,et al.  Network Pharmacology-Based Analysis of the Underlying Mechanism of Hyssopus cuspidatus Boriss. for Antiasthma: A Characteristic Medicinal Material in Xinjiang , 2021, Evidence-based Complementary and Alternative Medicine : eCAM.

[5]  Huimei Wu,et al.  Network Pharmacology and Molecular Docking Suggest the Mechanism for Biological Activity of Rosmarinic Acid , 2021, Evidence-based complementary and alternative medicine : eCAM.

[6]  Xiongbiao Wang,et al.  Investigation of the Active Ingredients and Mechanism of Polygonum cuspidatum in Asthma Based on Network Pharmacology and Experimental Verification , 2021, Drug design, development and therapy.

[7]  T. Homma,et al.  Airway Epithelial Dysfunction in Asthma: Relevant to Epidermal Growth Factor Receptors and Airway Epithelial Cells , 2020, Journal of clinical medicine.

[8]  Yi He,et al.  The AKT inhibitor MK2206 suppresses airway inflammation and the pro-remodeling pathway in a TDI-induced asthma mouse model , 2020, Molecular medicine reports.

[9]  Yanmin Lyu,et al.  Network Pharmacology-Based Study on the Mechanism of Pinellia ternata in Asthma Treatment , 2020, Evidence-based complementary and alternative medicine : eCAM.

[10]  Xiao-hong Liu,et al.  A network pharmacology-based strategy for predicting anti-inflammatory targets of ephedra in treating asthma. , 2020, International immunopharmacology.

[11]  E. Abduljawad.  Review of some evidenced medicinal activities of Acacia Nilotica , 2020 .

[12]  Zhihong Yu,et al.  MIF signaling blocking alleviates airway inflammation and airway epithelial barrier disruption in a HDM-induced asthma model. , 2019, Cellular immunology.

[13]  Jun Zhang,et al.  Antiasthmatic activity of quercetin glycosides in neonatal asthmatic rats , 2019, 3 Biotech.

[14]  R. Jame.  Phytochemical and Pharmacological Uses of Acacia Nilotica - A Review , 2019 .

[15]  Alamgeer,et al.  Traditional medicinal plants used for respiratory disorders in Pakistan: a review of the ethno-medicinal and pharmacological evidence , 2018, Chinese Medicine.

[16]  U. Chandran,et al.  Network ethnopharmacological evaluation of the immunomodulatory activity of Withania somnifera. , 2017, Journal of ethnopharmacology.

[17]  Muhammad Shahzad Aslam,et al.  Worldwide Importance of Medicinal Plants: Current and Historical Perspectives , 2016 .

[18]  P. J. Chilton,et al.  Use of traditional medicine in middle-income countries: a WHO-SAGE study , 2016, Health policy and planning.

[19]  M. Haase,et al.  HSP90AB1: Helping the good and the bad. , 2016, Gene.

[20]  Michael K. Gilson,et al.  BindingDB in 2015: A public database for medicinal chemistry, computational chemistry and systems pharmacology , 2015, Nucleic Acids Res..

[21]  Jiamin Li,et al.  Apigenin protects ovalbumin-induced asthma through the regulation of Th17 cells. , 2013, Fitoterapia.

[22]  J. McConville,et al.  Akt activation induces hypertrophy without contractile phenotypic maturation in airway smooth muscle. , 2011, American journal of physiology. Lung cellular and molecular physiology.

[23]  J. Whitsett,et al.  Epithelial EGF receptor signaling mediates airway hyperreactivity and remodeling in a mouse model of chronic asthma. , 2011, American journal of physiology. Lung cellular and molecular physiology.

[24]  Ying Shi,et al.  Apigenin inhibits allergen-induced airway inflammation and switches immune response in a murine model of asthma , 2010, Immunopharmacology and immunotoxicology.

[25]  P. Burgel,et al.  Epidermal growth factor receptor-mediated innate immune responses and their roles in airway diseases , 2008, European Respiratory Journal.

[26]  Chang Jong Kim,et al.  Anti-asthmatic action of quercetin and rutin in conscious guinea-pigs challenged with aerosolized ovalbumin , 2007, Archives of pharmacal research.

[27]  N. Aoike,et al.  Expression of vascular endothelial growth factor, basic fibroblast growth factor, and angiogenin immunoreactivity in asthmatic airways and its relationship to angiogenesis. , 2001, The Journal of allergy and clinical immunology.