Null association between prostate cancer and serum folate, vitamin B(6), vitamin B(12), and homocysteine.

Folate is necessary for DNA synthesis, repair, and methylation, and biological reactions involving folate require vitamins B6 and B12 as cofactors. Low concentrations of these vitamins can impair one-carbon metabolism pathways [(1)][1] , leading to homocysteine accumulation, insufficient methyl