论文信息 - In vitro investigation of the behaviour of magnetic particles by a circulating artery model

In vitro investigation of the behaviour of magnetic particles by a circulating artery model

Magnetic drug targeting is the use of coated magnetic nanoparticles as carriers for cytostatic drugs. After intraarterial application of these carriers, they are attracted with an external magnetic field to, for example, an experimental VX2 tumour. The biological compatibility of this system depends on several physiological and physical parameters. We established an in vitro model to simulate in vivo conditions in a circulating system consisting of a circuit with an intact bovine femoral artery close to an external magnetic field. Nanoparticle suspensions were applied by a side inlet. After the magnetisation procedure particle size, concentration and distribution was examined.

[1] Christoph Alexiou,et al. Targeting cancer cells: magnetic nanoparticles as drug carriers , 2006, European Biophysics Journal.

[2] C. Alexiou,et al. Magnetic drug targeting: biodistribution and dependency on magnetic field strength ☆ , 2002 .

[3] C. Alexiou,et al. In vitro and in vivo investigations of targeted chemotherapy with magnetic nanoparticles , 2005 .

[4] G. Vassal,et al. Negative preclinical results with stealth nanospheres-encapsulated Doxorubicin in an orthotopic murine brain tumor model. , 2004, Journal of controlled release : official journal of the Controlled Release Society.

[5] S. Milz,et al. Autologous Endothelialized Vein Allograft: A Solution in the Search for Small-Caliber Grafts in Coronary Artery Bypass Graft Operations , 2001, Circulation.

[6] Gert Storm,et al. Surface modification of nanoparticles to oppose uptake by the mononuclear phagocyte system , 1995 .

[7] Christoph Alexiou,et al. Magnetic Drug Targeting—Biodistribution of the Magnetic Carrier and the Chemotherapeutic agent Mitoxantrone after Locoregional Cancer Treatment , 2003 .

[8] C. Alexiou,et al. Locoregional cancer treatment with magnetic drug targeting. , 2000, Cancer research.

[9] R. Müller,et al. Nanosuspensions as particulate drug formulations in therapy. Rationale for development and what we can expect for the future. , 2001, Advanced drug delivery reviews.