An analgesic peptide H-20 attenuates chronic pain via the PD-1 pathway with few adverse effects

Significance Recently, lots of studies have demonstrated that programmed cell death protein 1 (PD-1) participates in the modulation of neuronal excitability, synaptic transmission, and synaptic plasticity in neurons. It is regarded as an alternative target to address the opioid crisis. However, no related ligands targeting PD-1 with analgesic potential have been reported except PD-L1. In this study, we screened an analgesic peptide H-20, which significantly inhibits acute pain and chronic pain via the PD-1 pathway with few adverse effects in multiple preclinical pain models. This finding will provide ideas for analgesic drug research and development.

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