Single-cell and spatial architecture of primary liver cancer

[1]  Guoan Xiang,et al.  Integrative epigenomic profiling reveal AP-1 is a key regulator in intrahepatich cholangiocarcinoma. , 2021, Genomics.

[2]  L. Elo,et al.  Compressive stress-mediated p38 activation required for ERα + phenotype in breast cancer , 2021, Nature Communications.

[3]  Hang Zheng,et al.  Integrated single-cell and bulk RNA sequencing analysis identifies a cancer associated fibroblast-related signature for predicting prognosis and therapeutic responses in colorectal cancer , 2021, Cancer Cell International.

[4]  R. Kalluri,et al.  Clinical and therapeutic relevance of cancer-associated fibroblasts , 2021, Nature Reviews Clinical Oncology.

[5]  Le Zhang,et al.  The LncRNA RP11-301G19.1/miR-582-5p/HMGB2 axis modulates the proliferation and apoptosis of multiple myeloma cancer cells via the PI3K/AKT signalling pathway , 2021, Cancer Gene Therapy.

[6]  D. Figeys,et al.  Identification of novel lipid droplet factors that regulate lipophagy and cholesterol efflux in macrophage foam cells , 2021, Autophagy.

[7]  Huanming Yang,et al.  Single-cell landscape of the ecosystem in early-relapse hepatocellular carcinoma , 2020, Cell.

[8]  Justine Jia Wen Seow,et al.  Onco-fetal Reprogramming of Endothelial Cells Drives Immunosuppressive Macrophages in Hepatocellular Carcinoma , 2020, Cell.

[9]  Yuan Zhang,et al.  Single cell transcriptomic architecture and intercellular crosstalk of human intrahepatic cholangiocarcinoma. , 2020, Journal of hepatology.

[10]  Haitao Zhao,et al.  Pembrolizumab combined with lenvatinib as non-first-line therapy in patients with refractory biliary tract carcinoma. , 2020, Hepatobiliary surgery and nutrition.

[11]  Rafael A. Irizarry,et al.  Robust decomposition of cell type mixtures in spatial transcriptomics , 2020, Nature Biotechnology.

[12]  Dan Zhang,et al.  Construction of a human cell landscape at single-cell level , 2020, Nature.

[13]  Ze-Guang Han,et al.  The Mutational Features of Aristolochic Acid–Induced Mouse and Human Liver Cancers , 2020, Hepatology.

[14]  Thea D. Tlsty,et al.  A framework for advancing our understanding of cancer-associated fibroblasts , 2020, Nature Reviews Cancer.

[15]  Itai Yanai,et al.  Integrating microarray-based spatial transcriptomics and single-cell RNA-seq reveals tissue architecture in pancreatic ductal adenocarcinomas , 2020, Nature Biotechnology.

[16]  A. Jemal,et al.  Cancer statistics, 2020 , 2020, CA: a cancer journal for clinicians.

[17]  Joakim Lundeberg,et al.  A Spatiotemporal Organ-Wide Gene Expression and Cell Atlas of the Developing Human Heart , 2019, Cell.

[18]  Xianwen Ren,et al.  Landscape and Dynamics of Single Immune Cells in Hepatocellular Carcinoma , 2019, Cell.

[19]  Li Ding,et al.  Integrated Proteogenomic Characterization of HBV-Related Hepatocellular Carcinoma , 2019, Cell.

[20]  Jonathan M. Hernandez,et al.  Tumor Cell Biodiversity Drives Microenvironmental Reprogramming in Liver Cancer. , 2019, Cancer cell.

[21]  Guoji Guo,et al.  Integrated multiomic analysis reveals comprehensive tumour heterogeneity and novel immunophenotypic classification in hepatocellular carcinomas , 2019, Gut.

[22]  Dominic Grün,et al.  A Human Liver Cell Atlas reveals Heterogeneity and Epithelial Progenitors , 2019, Nature.

[23]  X. Wang,et al.  Genomic and Transcriptomic Profiling of Combined Hepatocellular and Intrahepatic Cholangiocarcinoma Reveals Distinct Molecular Subtypes. , 2019, Cancer cell.

[24]  C. Swanton,et al.  Resolving genetic heterogeneity in cancer , 2019, Nature reviews genetics.

[25]  Mingwei Liu,et al.  Proteomics identifies new therapeutic targets of early-stage hepatocellular carcinoma , 2019, Nature.

[26]  William A. Pastor,et al.  SMARCA4 loss is synthetic lethal with CDK4/6 inhibition in non-small cell lung cancer , 2019, Nature Communications.

[27]  Radhika Mathur ARID1A loss in cancer: Towards a mechanistic understanding , 2018, Pharmacology & therapeutics.

[28]  Ambrose J. Carr,et al.  Single-Cell Map of Diverse Immune Phenotypes in the Breast Tumor Microenvironment , 2018, Cell.

[29]  Erik Sundström,et al.  RNA velocity of single cells , 2018, Nature.

[30]  P. Carmeliet,et al.  Phenotype molding of stromal cells in the lung tumor microenvironment , 2018, Nature Medicine.

[31]  Ruibin Xi,et al.  Spatial and temporal clonal evolution of intrahepatic cholangiocarcinoma. , 2018, Journal of hepatology.

[32]  Chengzhong Ye,et al.  Single-cell profiling of breast cancer T cells reveals a tissue-resident memory subset associated with improved prognosis , 2018, Nature Medicine.

[33]  G. Wilkes Targeted Therapy: Attacking Cancer with Molecular and Immunological Targeted Agents , 2018, Asia-Pacific journal of oncology nursing.

[34]  Haitao Zhao,et al.  Whole-exome sequencing reveals the origin and evolution of hepato-cholangiocarcinoma , 2018, Nature Communications.

[35]  Ruibin Xi,et al.  Diverse modes of clonal evolution in HBV-related hepatocellular carcinoma revealed by single-cell genome sequencing , 2018, Cell Research.

[36]  Li Yang,et al.  A single‐cell transcriptomic analysis reveals precise pathways and regulatory mechanisms underlying hepatoblast differentiation , 2017, Hepatology.

[37]  Ludmila V. Danilova,et al.  Mismatch repair deficiency predicts response of solid tumors to PD-1 blockade , 2017, Science.

[38]  Y. Pomyen,et al.  Common Molecular Subtypes Among Asian Hepatocellular Carcinoma and Cholangiocarcinoma. , 2017, Cancer cell.

[39]  Boxi Kang,et al.  Landscape of Infiltrating T Cells in Liver Cancer Revealed by Single-Cell Sequencing , 2017, Cell.

[40]  Richard A. Moore,et al.  Comprehensive and Integrative Genomic Characterization of Hepatocellular Carcinoma , 2017, Cell.

[41]  Richard A. Moore,et al.  Integrative Genomic Analysis of Cholangiocarcinoma Identifies Distinct IDH-Mutant Molecular Profiles , 2017, Cell reports.

[42]  I. Amit,et al.  Single-cell spatial reconstruction reveals global division of labor in the mammalian liver , 2016, Nature.

[43]  Patrik L. Ståhl,et al.  Visualization and analysis of gene expression in tissue sections by spatial transcriptomics , 2016, Science.

[44]  A. Jemal,et al.  Cancer statistics in China, 2015 , 2016, CA: a cancer journal for clinicians.

[45]  Fabian J. Theis,et al.  destiny: diffusion maps for large-scale single-cell data in R , 2015, Bioinform..

[46]  Mikhail Pogorelyy,et al.  tcR: an R package for T cell receptor repertoire advanced data analysis , 2015, BMC Bioinformatics.

[47]  Nansheng Chen,et al.  Mutational landscape of intrahepatic cholangiocarcinoma , 2014, Nature Communications.

[48]  W. Cong,et al.  Background progenitor activation is associated with recurrence after hepatectomy of combined hepatocellular‐cholangiocarcinoma , 2012, Hepatology.

[49]  R. Doms,et al.  Kruppel-like Factor 2 Modulates CCR5 Expression and Susceptibility to HIV-1 Infection , 2012, The Journal of Immunology.

[50]  E. Wagner,et al.  The Fos‐related antigen Fra‐1 is an activator of bone matrix formation , 2004, The EMBO journal.