SD-OCT with prolonged scan depth for imaging the anterior segment of the eye.

An 840-nm wavelength spectral domain optical coherence tomography (SD-OCT) with prolonged scan depth was developed and mounted onto a conventional slit lamp for imaging the anterior segment of the eye. X-Y cross aiming was applied to align the SD-OCT scanning position during imaging. An internal fixation target displayed on a miniature LCD monitor was provided. The SD-OCT instrument had an axial resolution of 6 μm and a prolonged scan depth of 7.2 mm. High-quality SD-OCT images, consisting of 2,048 × 2,048 pixels, were acquired of the entire anterior chamber and entire crystalline lens from a healthy subject. The entire cornea, anterior chamber angle, limbus, and iris were clearly visible. Additionally, the internal structure of crystalline lens, including anterior and posterior surfaces of the crystalline lens, capsule, nucleus, and cortex, were clearly imaged with the instrument. The system was also tested in imaging accommodation of the same eye, demonstrating the feasibility of the novel approach for evaluating presbyopia/accommodation.

[1]  C. A. Cook,et al.  Accommodation and presbyopia in the human eye. Changes in the anterior segment and crystalline lens with focus. , 1997, Investigative ophthalmology & visual science.

[2]  Maciej Wojtkowski,et al.  Improved complex spectral domain OCT for in vivo eye imaging , 2005 .

[3]  Michael Pircher,et al.  Full range complex spectral domain optical coherence tomography without additional phase shifters. , 2007, Optics express.

[4]  Hiroshi Ishikawa,et al.  Anterior segment imaging: ultrasound biomicroscopy. , 2004, Ophthalmology clinics of North America.

[5]  Jay Wei,et al.  Anterior chamber optical coherence tomography study of human natural accommodation in a 19-year-old albino. , 2004, Journal of cataract and refractive surgery.

[6]  Mark Dunne,et al.  Phakometric measurement of ocular surface radii of curvature, axial separations and alignment in relaxed and accommodated human eyes , 2004, Ophthalmic & physiological optics : the journal of the British College of Ophthalmic Opticians.

[7]  Chuanqing Zhou,et al.  Dual channel dual focus optical coherence tomography for imaging accommodation of the eye. , 2009, Optics express.

[8]  R. Leitgeb,et al.  High speed full range complex spectral domain optical coherence tomography. , 2005, Optics express.

[9]  Iwona Gorczynska,et al.  Anterior segment imaging with Spectral OCT system using a high-speed CMOS camera. , 2009, Optics express.

[10]  C. Leung,et al.  Visualization of anterior chamber angle dynamics using optical coherence tomography. , 2005, Ophthalmology.

[11]  Karla Zadnik,et al.  Lens thickness with age and accommodation by optical coherence tomography , 2008, Ophthalmic & physiological optics : the journal of the British College of Ophthalmic Opticians.

[12]  J. D. de Boer,et al.  Large depth-high resolution full 3D imaging of the anterior segments of the eye using high speed optical frequency domain imaging. , 2007, Optics express.

[13]  J. Izatt,et al.  Real-time optical coherence tomography of the anterior segment at 1310 nm. , 2001, Archives of ophthalmology.

[14]  Maciej Wojtkowski,et al.  Imaging of the anterior segment of the eye by spectral optical coherence tomography , 2002 .

[15]  Marinko V Sarunic,et al.  Imaging the ocular anterior segment with real-time, full-range Fourier-domain optical coherence tomography. , 2008, Archives of ophthalmology.

[16]  Michael Pircher,et al.  Extended in vivo anterior eye-segment imaging with full-range complex spectral domain optical coherence tomography. , 2009, Journal of biomedical optics.

[17]  Susana Marcos,et al.  Crystalline lens radii of curvature from Purkinje and Scheimpflug imaging. , 2006, Journal of vision.

[18]  Jay Wei,et al.  Static and dynamic analysis of the anterior segment with optical coherence tomography , 2004, Journal of cataract and refractive surgery.

[19]  T. Yatagai,et al.  Three-dimensional and high-speed swept-source optical coherence tomography for in vivo investigation of human anterior eye segments. , 2005, Optics express.