In Vivo Tests of Implantable Antennas in Rats: Antenna Size and Intersubject Considerations

We propose and implement an experimental protocol for in vivo testing of implantable antennas in rats, which aims to quantify dependence of the exhibited resonance performance upon antenna size and intersubject and surgical procedure variability. Two implantable antennas with occupied volumes of 204 and 399 mm3 are tested inside three different rats each. Investigations are carried out in the Medical Implant Communications Service (MICS) band (402-405 MHz). Intersubject and surgical procedure variations are found to quite affect the exhibited reflection coefficient frequency response, with reduction in antenna size further increasing sensitivity. Compared to simulations, maximum deviations in the center resonance frequency within the bandwidth and 10-dB bandwidth equal -6.5% and +30.2% for the 204-mm3 antenna, and -1.7% and -14.9% for the 399-mm3 antenna. Antenna radiation and safety performance are finally assessed for glucose monitoring applications.

[1]  A. Kiourti,et al.  A Review of Implantable Patch Antennas for Biomedical Telemetry: Challenges and Solutions [Wireless Corner] , 2012, IEEE Antennas and Propagation Magazine.

[2]  U. Kawoos,et al.  In-Vitro and In-Vivo Trans-Scalp Evaluation of an Intracranial Pressure Implant at 2.4 GHz , 2008, IEEE Transactions on Microwave Theory and Techniques.

[3]  Asimina Kiourti,et al.  Implantable and ingestible medical devices with wireless telemetry functionalities: A review of current status and challenges , 2014, Bioelectromagnetics.

[4]  A. K. Skrivervik,et al.  Example of Data Telemetry for Biomedical Applications: An In Vivo Experiment , 2012, IEEE Antennas and Wireless Propagation Letters.

[5]  Minkyu Je,et al.  Differentially Fed Dual-Band Implantable Antenna for Biomedical Applications , 2012, IEEE Transactions on Antennas and Propagation.

[6]  E. Topsakal,et al.  Dielectric Properties of Porcine Skin Tissue and In Vivo Testing of Implantable Antennas Using Pigs as Model Animals , 2012, IEEE Antennas and Wireless Propagation Letters.

[7]  M. Samet,et al.  Parametric study on the dielectric properties of biological tissues , 2015, 2015 16th International Conference on Sciences and Techniques of Automatic Control and Computer Engineering (STA).

[8]  C Gabriel,et al.  The dielectric properties of biological tissues: I. Literature survey. , 1996, Physics in medicine and biology.

[9]  A. Kiourti,et al.  Miniature Scalp-Implantable Antennas for Telemetry in the MICS and ISM Bands: Design, Safety Considerations and Link Budget Analysis , 2012, IEEE Transactions on Antennas and Propagation.

[10]  Oscar Quevedo-Teruel,et al.  Dual-band microstrip patch antenna based on short-circuited ring and spiral resonators for implantable medical devices , 2010 .

[11]  Konstantina S. Nikita,et al.  A Broadband Implantable and a Dual-Band On-Body Repeater Antenna: Design and Transmission Performance , 2014, IEEE Transactions on Antennas and Propagation.

[12]  Ieee Standards Board.  IEEE standard for safety levels with respect to human exposure to radio frequency electromagnetic fields, 3kHz to 300 GHz , 1992 .

[13]  Yang Hao,et al.  Numerical Characterization and Link Budget Evaluation of Wireless Implants Considering Different Digital Human Phantoms , 2009, IEEE Transactions on Microwave Theory and Techniques.

[14]  Tutku Karacolak,et al.  In Vivo Verification of Implantable Antennas Using Rats as Model Animals , 2010, IEEE Antennas and Wireless Propagation Letters.