Pharmacological analysis of directionally sensitive rabbit retinal ganglion cells

1. Cholinergic drugs were infused into the retinal circulation of the rabbit while we analysed the receptive field properties of directionally sensitive retinal ganglion cells. Physostigmine eliminated the trigger feature, directional specificity, of both types (on‐centre and on—off) of these cells. In this respect the action of physostigmine (an ACh potentiator) was very like that of picrotoxin (a GABA antagonist). Therefore, a detailed analysis of the receptive field properties of directionally sensitive ganglion cells was made to analyse the effects of physostigmine and picrotoxin.

[1]  H. Barlow,et al.  Selective Sensitivity to Direction of Movement in Ganglion Cells of the Rabbit Retina , 1963, Science.

[2]  H. Barlow,et al.  Retinal ganglion cells responding selectively to direction and speed of image motion in the rabbit , 1964, The Journal of physiology.

[3]  H. Barlow,et al.  The mechanism of directionally selective units in rabbit's retina. , 1965, The Journal of physiology.

[4]  C. W. Oyster,et al.  The analysis of image motion by the rabbit retina , 1968, The Journal of physiology.

[5]  C. W. Oyster,et al.  Direction-selective retinal ganglion cells and control of optokinetic nystagmus in the rabbit. , 1972, Vision research.

[6]  F S Werblin,et al.  Lateral Interactions at Inner Plexiform Layer of Vertebrate Retina: Antagonistic Responses to Change , 1972, Science.

[7]  N. Daw,et al.  Raising rabbits in a moving visual environment: an attempt to modify directional sensitivity in the retina , 1974, The Journal of physiology.

[8]  N. Daw,et al.  Directionally sensitive ganglion cells in the rabbit retina: specificity for stimulus direction, size, and speed. , 1975, Journal of neurophysiology.

[9]  H. J. Wyatt,et al.  Specific effects of neurotransmitter antagonists on ganglion cells in rabbit retina. , 1976, Science.

[10]  R H Masland,et al.  Responses to acetylcholine of ganglion cells in an isolated mammalian retina. , 1976, Journal of neurophysiology.

[11]  J. Caldwell,et al.  Effects of picrotoxin and strychnine on rabbit retinal ganglion cells: lateral interactions for cells with more complex receptive fields. , 1978, The Journal of physiology.

[12]  J. Caldwell,et al.  Effects of picrotoxin and strychnine on rabbit retinal ganglion cells: changes in centre surround receptive fields. , 1978, The Journal of physiology.

[13]  J. Caldwell,et al.  New properties of rabbit retinal ganglion cells. , 1978, The Journal of physiology.

[14]  D. Baylor,et al.  Synaptic drive and impulse generation in ganglion cells of turtle retina. , 1979, The Journal of physiology.

[15]  P. Marchiafava.  The responses of retinal ganglion cells to stationary and moving visual stimuli , 1979, Vision Research.

[16]  S. Massey,et al.  The release of acetylcholine and amino acids from the rabbit retina in vivo , 1980, Neurochemistry International.

[17]  J. Wu,et al.  Immunocytochemical localization of GABA neurons in the rabbit and frog retina , 1980, Brain Research Bulletin.

[18]  M. Ariel,et al.  Effects of cholinergic drugs on receptive field properties of rabbit retinal ganglion cells , 1982, The Journal of physiology.