Orthopaedic applications of gene therapy

[1]  Lars G. Gilbertson,et al.  Gene Transfer of the Catabolic Inhibitor TIMP-1 Increases Measured Proteoglycans in Cells from Degenerated Human Intervertebral Discs , 2003, Spine.

[2]  P. Mantyh,et al.  Direct and bystander killing of sarcomas by novel cytosine deaminase fusion gene. , 2003, Cancer research.

[3]  T. Yoshimoto,et al.  Retrovirus-mediated transduction of TRAIL and chemotherapeutic agents co-operatively induce apoptotic cell death in both sarcoma and myeloma cells. , 2003, Anticancer research.

[4]  J. Mason,et al.  Stem Cells as Platforms for Delivery of Genes to Enhance Cartilage Repair , 2003, The Journal of bone and joint surgery. American volume.

[5]  Min Zhu,et al.  Human adipose tissue is a source of multipotent stem cells. , 2002, Molecular biology of the cell.

[6]  S. Santavirta,et al.  Recombinant Human Bone Morphogenetic Protein-2 for Treatment of Open Tibial Fractures: A Prospective, Controlled, Randomized Study of Four Hundred and Fifty Patients , 2002, The Journal of bone and joint surgery. American volume.

[7]  R. Balderston,et al.  Clinical and Radiographic Outcomes of Anterior Lumbar Interbody Fusion Using Recombinant Human Bone Morphogenetic Protein-2 , 2002, Spine.

[8]  Johnny Huard,et al.  Synergistic enhancement of bone formation and healing by stem cell-expressed VEGF and bone morphogenetic protein-4. , 2002, The Journal of clinical investigation.

[9]  R. Rutherford,et al.  Bone morphogenetic protein-transduced human fibroblasts convert to osteoblasts and form bone in vivo. , 2002, Tissue engineering.

[10]  S. Govender,et al.  Staged reduction and stabilisation in chronic atlantoaxial rotatory fixation. , 2002, The Journal of bone and joint surgery. British volume.

[11]  S. Abboud,et al.  Rescue of the osteopetrotic defect in op/op mice by osteoblast-specific targeting of soluble colony-stimulating factor-1. , 2002, Endocrinology.

[12]  E. Schwarz,et al.  Efficacy of ex vivo OPG gene therapy in preventing wear debris induced osteolysis , 2002, Journal of orthopaedic research : official publication of the Orthopaedic Research Society.

[13]  P. Robbins,et al.  Transfer of proα2(I) cDNA into cells of a murine model of human Osteogenesis Imperfecta restores synthesis of type I collagen comprised of α1(I) and α2(I) heterotrimers in vitro and in vivo , 2001 .

[14]  R. Müller,et al.  Engineered human mesenchymal stem cells: a novel platform for skeletal cell mediated gene therapy , 2001, The journal of gene medicine.

[15]  G. Zych,et al.  Osteogenic Protein-1 (Bone Morphogenetic Protein-7) in the Treatment of Tibial Nonunions: A Prospective, Randomized Clinical Trial Comparing rhOP-1 with Fresh Bone Autograft* , 2001, The Journal of bone and joint surgery. American volume.

[16]  James D. Kang,et al.  Human Intervertebral Disc Cells Are Genetically Modifiable by Adenovirus-Mediated Gene Transfer: Implications for the Clinical Management of Intervertebral Disc Disorders , 2000, Spine.

[17]  U. Liljenqvist,et al.  Segmental pedicle screw instrumentation in idiopathic thoracolumbar and lumbar scoliosis , 2000, European Spine Journal.

[18]  P. Robbins,et al.  Genetic enhancement of fracture repair: healing of an experimental segmental defect by adenoviral transfer of the BMP-2 gene , 2000, Gene Therapy.

[19]  H. Chiou,et al.  Obstacles and advances in non-viral gene delivery. , 2000, Current opinion in molecular therapeutics.

[20]  J. Engh,et al.  Use of bone morphogenetic protein-9 gene therapy to induce spinal arthrodesis in the rodent. , 2000, Journal of neurosurgery.

[21]  L G Gilbertson,et al.  Modulation of the biologic activity of the rabbit intervertebral disc by gene therapy: an in vivo study of adenovirus-mediated transfer of the human transforming growth factor beta 1 encoding gene. , 1999, Spine.

[22]  Sally Lehrman,et al.  Virus treatment questioned after gene therapy death , 1999, Nature.

[23]  Jeffrey Bonadio,et al.  Localized, direct plasmid gene delivery in vivo: prolonged therapy results in reproducible tissue regeneration , 1999, Nature Medicine.

[24]  A Daluiski,et al.  The effect of regional gene therapy with bone morphogenetic protein-2-producing bone-marrow cells on the repair of segmental femoral defects in rats. , 1999, The Journal of bone and joint surgery. American volume.

[25]  P. Robbins,et al.  Adenovirus-mediated direct gene therapy with bone morphogenetic protein-2 produces bone. , 1999, Bone.

[26]  L. Titus,et al.  1998 Volvo Award Winner in Basic Science Studies: Lumbar Spine Fusion by Local Gene Therapy With a cDNA Encoding a Novel Osteoinductive Protein (LMP‐1) , 1998, Spine.

[27]  James D. Kang,et al.  Adenovirus‐Mediated Gene Transfer to Nucleus Pulposus Cells: Implications for the Treatment of Intervertebral Disc Degeneration , 1998, Spine.

[28]  N. Wright,et al.  Induction of Bone Formation Using a Recombinant Adenoviral Vector Carrying the Human BMP-2 Gene in a Rabbit Spinal Fusion Model , 1998, Calcified Tissue International.

[29]  J. P. Thompson,et al.  Stimulation of Mature Canine Intervertebral Disc by Growth Factors , 1991, Spine.

[30]  C. Niyibizi,et al.  Transfer of proalpha2(I) cDNA into cells of a murine model of human Osteogenesis Imperfecta restores synthesis of type I collagen comprised of alpha1(I) and alpha2(I) heterotrimers in vitro and in vivo. , 2001, Journal of cellular biochemistry.

[31]  P. Robbins,et al.  Viral vectors for gene therapy. , 1998, Trends in biotechnology.