Moderators of working memory deficits in children with attention-deficit/hyperactivity disorder (ADHD): a meta-analytic review.

Working memory has assumed a prominent role as a primary neurocognitive deficit or endophenotype in extant models of attention-deficit/hyperactivity disorder (ADHD). The current study updated previous reviews and employed meta-analytic techniques to examine a broad range of moderating variables of effect size heterogeneity across phonological and visuospatial working memory tasks. Collectively, results revealed large between-group effect sizes across both working memory domains. In addition, several sample (percent female) and task (number of experimental trials, recall vs. recognition tasks, and demands on the central executive) moderating variables explained significant effect size variability among phonological and visuospatial studies. These findings suggest that children with ADHD exhibit statistically significant, large magnitude working memory deficits relative to their typically developing peers.

[1]  Joseph S. Raiker,et al.  Hyperactivity in Boys with Attention-Deficit/Hyperactivity Disorder (ADHD): A Ubiquitous Core Symptom or Manifestation of Working Memory Deficits? , 2009, Journal of abnormal child psychology.

[2]  Speech discrimination and phonological working memory in children with ADHD , 1999, Developmental medicine and child neurology.

[3]  Rosemary Tannock,et al.  Listening Comprehension and Working Memory Are Impaired in Attention-Deficit Hyperactivity Disorder Irrespective of Language Impairment , 2003, Journal of abnormal child psychology.

[4]  T. Banaschewski,et al.  Phonological short-term memory and central executive processing in attention-deficit/hyperactivity disorder with/without dyslexia – evidence of cognitive overlap , 2007, Journal of Neural Transmission.

[5]  M. Snowling,et al.  Executive function and reading impairments in children reported by their teachers as ‘hyperactive’ , 2001 .

[6]  F. Craik,et al.  Functional Neuroanatomy of Recall and Recognition: A PET Study of Episodic Memory , 1997, Journal of Cognitive Neuroscience.

[7]  Randall W Engle,et al.  Working memory, short-term memory, and general fluid intelligence: a latent-variable approach. , 1999, Journal of experimental psychology. General.

[8]  R. Tannock,et al.  Neuropsychological profiles of adolescents with ADHD: effects of reading difficulties and gender. , 2002, Journal of child psychology and psychiatry, and allied disciplines.

[9]  Abraham R. Schneider,et al.  Theoretical correlations and measured correlations: relating recognition and recall in four distributed memory models. , 2005, Journal of experimental psychology. Learning, memory, and cognition.

[10]  R. Barkley,et al.  Neuropsychological and academic functioning in preschool boys with attention deficit hyperactivity disorder. , 1997 .

[11]  Randall W. Engle,et al.  Forward and backward serial recall , 1997 .

[12]  R. Drechsler,et al.  Decision-making on an explicit risk-taking task in preadolescents with attention-deficit/hyperactivity disorder , 2007, Journal of Neural Transmission.

[13]  Claire Hughes,et al.  Executive function deficits in autism spectrum disorders and attention-deficit/hyperactivity disorder: Examining profiles across domains and ages , 2006, Brain and Cognition.

[14]  N. Brunswick,et al.  Early cognitive profiles of emergent readers: a longitudinal study. , 2012, Journal of experimental child psychology.

[15]  Michael F. Bunting,et al.  The cocktail party phenomenon revisited: The importance of working memory capacity , 2001, Psychonomic bulletin & review.

[16]  A. Baddeley.  Working memory: looking back and looking forward , 2003, Nature Reviews Neuroscience.

[17]  R. Schachar,et al.  Validating psychiatric endophenotypes: Inhibitory control and attention deficit hyperactivity disorder , 2008, Neuroscience & Biobehavioral Reviews.

[18]  Joseph Biederman,et al.  The age-dependent decline of attention deficit hyperactivity disorder: a meta-analysis of follow-up studies , 2005, Psychological Medicine.

[19]  K. Nation,et al.  Learning to read changes children's phonological skills: evidence from a latent variable longitudinal study of reading and nonword repetition. , 2011, Developmental science.

[20]  G. August,et al.  Processing of emotional information in children with attention‐deficit hyperactivity disorder , 1993 .

[21]  Michael J. Kofler,et al.  Competing Core Processes in Attention-Deficit/Hyperactivity Disorder (ADHD): Do Working Memory Deficiencies Underlie Behavioral Inhibition Deficits? , 2010, Journal of abnormal child psychology.

[22]  Mark W. Lipsey,et al.  Practical Meta-Analysis , 2000 .

[23]  Hans Forssberg,et al.  Visuo-Spatial Working Memory Span: A Sensitive Measure of Cognitive Deficits in Children With ADHD , 2004, Child neuropsychology : a journal on normal and abnormal development in childhood and adolescence.

[24]  S. Gau,et al.  Executive Function in Adolescence Among Children With Attention-Deficit/Hyperactivity Disorder in Taiwan , 2009, Journal of developmental and behavioral pediatrics : JDBP.

[25]  V. Douglas,et al.  Attention deficit hyperactivity disorder and the frontal lobe syndrome , 1992, Brain and Cognition.

[26]  R. Gullapalli,et al.  Working Memory in Attention Deficit/Hyperactivity Disorder is Characterized by a Lack of Specialization of Brain Function , 2011, PloS one.

[27]  C. Huang-Pollock,et al.  Working memory demands impair skill acquisition in children with ADHD. , 2010, Journal of abnormal psychology.

[28]  B. Pennington,et al.  A comparison of the cognitive deficits in reading disability and attention-deficit/hyperactivity disorder. , 2001, Journal of abnormal psychology.

[29]  Jeffrey S. Skowronek,et al.  Long‐Term Episodic Memory in Children with Attention‐Deficit/Hyperactivity Disorder , 2008 .

[30]  J. Schweitzer,et al.  Is there evidence for neural compensation in attention deficit hyperactivity disorder? A review of the functional neuroimaging literature. , 2006, Clinical psychology review.

[31]  Catalina J. Hooper,et al.  The development of nonverbal working memory and executive control processes in adolescents. , 2005, Child development.

[32]  G. Chase,et al.  ADHD Subtypes and Co-Occurring Anxiety, Depression, and Oppositional-Defiant Disorder , 2009, Journal of attention disorders.

[33]  L. Weyandt,et al.  ADHD in College Students , 2006, Journal of attention disorders.

[34]  B. Luna,et al.  Oculomotor performance identifies underlying cognitive deficits in attention-deficit/hyperactivity disorder. , 2009, Journal of the American Academy of Child and Adolescent Psychiatry.

[35]  R Tannock,et al.  Time perception deficits in attention-deficit/ hyperactivity disorder and comorbid reading difficulties in child and adolescent samples. , 2003, Journal of child psychology and psychiatry, and allied disciplines.

[36]  G. Bohlin,et al.  Executive Functions in Children Aged 6 to 13: A Dimensional and Developmental Study , 2004, Developmental neuropsychology.

[37]  Torkel Klingberg,et al.  Training of Working Memory , 2006 .

[38]  Janet B W Williams,et al.  Diagnostic and Statistical Manual of Mental Disorders , 2013 .

[39]  Joseph S. Raiker,et al.  ADHD and Working Memory: The Impact of Central Executive Deficits and Exceeding Storage/Rehearsal Capacity on Observed Inattentive Behavior , 2010, Journal of abnormal child psychology.

[40]  Laura S. Guy,et al.  Does psychopathy predict institutional misconduct among adults? A meta-analytic investigation. , 2005, Journal of consulting and clinical psychology.

[41]  P. Mattos,et al.  Neuropsychological differences between attention deficit hyperactivity disorder and control children and adolescents referred for academic impairment. , 2009, Revista brasileira de psiquiatria.

[42]  D. Mennin,et al.  A pilot study of neuropsychological function in girls with ADHD. , 1997, Journal of the American Academy of Child and Adolescent Psychiatry.

[43]  B. Horta,et al.  The worldwide prevalence of ADHD: a systematic review and metaregression analysis. , 2007, The American journal of psychiatry.

[44]  R. R. Abidin.  Psychological Assessment Resources , 1995 .

[45]  C. Junqué,et al.  Right Hemisphere Dysfunction in Subjects With Attention-Deficit Disorder With and Without Hyperactivity , 1997, Journal of child neurology.

[46]  J. D. Ball,et al.  Neuropsychological Characteristics of Adults with ADHD: A Comprehensive Review of Initial Studies , 2002, The Clinical neuropsychologist.

[47]  W. Adams,et al.  Wide Range Assessment of Memory and Learning Second Edition TM Screening Report , 2010 .

[48]  B. Astor,et al.  Subtle Executive Impairment in Children with Autism and Children with ADHD , 2005, Journal of autism and developmental disorders.

[49]  J. Sergeant,et al.  The impact of specific language impairment on working memory in children with ADHD combined subtype. , 2005, Archives of clinical neuropsychology : the official journal of the National Academy of Neuropsychologists.

[50]  Danielle Mizuiri,et al.  A lack of default network suppression is linked to increased distractibility in ADHD , 2009, Brain Research.

[51]  J. Sergeant,et al.  Differential effects of atomoxetine on executive functioning and lexical decision in attention-deficit/hyperactivity disorder and reading disorder. , 2009, Journal of child and adolescent psychopharmacology.

[52]  H. Kraemer,et al.  Observed Classroom Behavior of Children with ADHD: Relationship to Gender and Comorbidity , 2002, Journal of abnormal child psychology.

[53]  T. Alloway.  A comparison of working memory profiles in children with ADHD and DCD , 2011, Child neuropsychology : a journal on normal and abnormal development in childhood and adolescence.

[54]  S. Beck,et al.  Journal of Clinical Child & Adolescent Psychology a Controlled Trial of Working Memory Training for Children and Adolescents with Adhd , 2022 .

[55]  Sverker Sikström,et al.  Listen to the noise: noise is beneficial for cognitive performance in ADHD. , 2007, Journal of child psychology and psychiatry, and allied disciplines.

[56]  Antonio Pisani,et al.  Acetylcholine-mediated modulation of striatal function , 2000, Trends in Neurosciences.

[57]  C. Gillberg,et al.  Cognitive strengths and deficits in schoolchildren with ADHD , 2007, Acta paediatrica.

[58]  D. Altman,et al.  Measurement error. , 1996, BMJ.

[59]  J. Luby,et al.  Preschool onset attention-deficit/hyperactivity disorder: course and predictors of stability over 24 months. , 2011, Journal of child and adolescent psychopharmacology.

[60]  M. W. van der Molen,et al.  Effectiveness of a computerised working memory training in adolescents with mild to borderline intellectual disabilities. , 2010, Journal of intellectual disability research : JIDR.

[61]  F. Castellanos,et al.  Neuroscience of attention-deficit/hyperactivity disorder: the search for endophenotypes , 2002, Nature Reviews Neuroscience.

[62]  M. Sawyer,et al.  Gender differences among children with DSM-IV ADHD in Australia. , 2005, Journal of the American Academy of Child and Adolescent Psychiatry.

[63]  R. Chan,et al.  Time perception deficit in children with ADHD , 2007, Brain Research.

[64]  B. Pennington,et al.  Executive functions and developmental psychopathology. , 1996, Journal of child psychology and psychiatry, and allied disciplines.

[65]  Philip D. Harvey,et al.  Working Memory Performance in Poor Outcome Schizophrenia: Relationship to Age and Executive Functioning , 2004, Journal of clinical and experimental neuropsychology.

[66]  A. Convit,et al.  The application of the first order system transfer function for fitting The California Verbal Learning Test Learning Curve , 2010, Journal of the International Neuropsychological Society.

[67]  J. L. Tang,et al.  Misleading funnel plot for detection of bias in meta-analysis. , 2000, Journal of clinical epidemiology.

[68]  S. Mostofsky,et al.  Neuropsychological profile of executive function in girls with attention-deficit/hyperactivity disorder. , 2010, Archives of clinical neuropsychology : the official journal of the National Academy of Neuropsychologists.

[69]  O. Wilhelm,et al.  Working memory capacity - facets of a cognitive ability construct , 2000 .

[70]  F. Craik,et al.  Age differences in recall and recognition , 1987 .

[71]  A. Baddeley.  Working Memory, Thought, and Action , 2007 .

[72]  J. Norris,et al.  Effectiveness of L2 Instruction: A Research Synthesis and Quantitative Meta‐analysis , 2000 .

[73]  Tracy Packiam Alloway,et al.  Verbal and visuospatial short-term and working memory in children: are they separable? , 2006, Child development.

[74]  M. Rapport,et al.  A Conceptual Model of Child Psychopathology: Implications for Understanding Attention Deficit Hyperactivity Disorder and Treatment Efficacy , 2001, Journal of clinical child psychology.

[75]  H. Forssberg,et al.  Training of Working Memory in Children With ADHD , 2002 .

[76]  P. Maruff,et al.  Abnormal executive function in attention deficit hyperactivity disorder: the effect of stimulant medication and age on spatial working memory , 2001, Psychological Medicine.

[77]  E. Gorenstein,et al.  Performance of inattentive-overactive children on selected measures of prefrontal-type function. , 1989, Journal of clinical psychology.

[78]  S. Faraone,et al.  Age-dependent decline of symptoms of attention deficit hyperactivity disorder: impact of remission definition and symptom type. , 2000, The American journal of psychiatry.

[79]  J. Sergeant,et al.  How Distinctive are ADHD and RD? Results of a Double Dissociation Study , 2009, Journal of abnormal child psychology.

[80]  D. Zee,et al.  Oculomotor anomalies in attention-deficit/hyperactivity disorder: evidence for deficits in response preparation and inhibition. , 2009, Journal of the American Academy of Child and Adolescent Psychiatry.

[81]  J. Glutting,et al.  Estimated Prevalence of Attention-Deficit/ Hyperactivity Disorder Symptoms Among College Freshmen , 2008, Journal of learning disabilities.

[82]  L. Hedges,et al.  Notes on Subgroup Analyses and Meta‐Regression , 2009, Introduction to Meta‐Analysis.

[83]  Melissa E. Libertus,et al.  Electrophysiological evidence for notation independence in numerical processing , 2007, Behavioral and Brain Functions.

[84]  J. Pujol,et al.  Magnetic resonance imaging measurement of the caudate nucleus in adolescents with attention-deficit hyperactivity disorder and its relationship with neuropsychological and behavioral measures. , 1997, Archives of neurology.

[85]  T. Kircher,et al.  Cross-sectional evaluation of cognitive functioning in children, adolescents and young adults with ADHD , 2010, Journal of Neural Transmission.

[86]  M. Welsh,et al.  Towers of Hanoi and London: Is the Nonshared Variance Due to Differences in Task Administration? , 2000, Perceptual and motor skills.

[87]  V. Sims,et al.  Working Memory Deficits in Boys with Attention-deficit/Hyperactivity Disorder (ADHD): The Contribution of Central Executive and Subsystem Processes , 2008, Journal of abnormal child psychology.

[88]  Patrick Lemaire,et al.  Children's strategies in complex arithmetic. , 2009, Journal of experimental child psychology.

[89]  K. Jarratt,et al.  Digit Span components as predictors of attention problems and executive functioning in children. , 2006, Archives of clinical neuropsychology : the official journal of the National Academy of Neuropsychologists.

[90]  G. Holmbeck.  Toward terminological, conceptual, and statistical clarity in the study of mediators and moderators: examples from the child-clinical and pediatric psychology literatures. , 1997, Journal of consulting and clinical psychology.

[91]  L. Rohde,et al.  Neuropsychological Performance in DSM-IV ADHD Subtypes: An Exploratory Study with Untreated Adolescents , 2002, Canadian journal of psychiatry. Revue canadienne de psychiatrie.

[92]  Kerry Lee,et al.  Central executive involvement in children's spatial memory , 2008, Memory.

[93]  M. Kliegel,et al.  Time-Based Prospective Memory Performance and Time-Monitoring in Children with ADHD , 2010, Child neuropsychology : a journal on normal and abnormal development in childhood and adolescence.

[94]  Jack Stevens,et al.  Working Memory in Children with ADHD , 2005 .

[95]  R. Tannock,et al.  Executive Dysfunction in School-Age Children With ADHD , 2011, Journal of attention disorders.

[96]  R. Engle,et al.  Individual differences in working memory capacity and what they tell us about controlled attention, general fluid intelligence, and functions of the prefrontal cortex. , 1999 .

[97]  P. Curatolo,et al.  Attention and executive functions profile in drug naive ADHD subtypes , 2007, Brain and Development.

[98]  Meredyth Daneman,et al.  Compensating for a Limited Working Memory Capacity During Reading: Evidence from Eye Movements , 2007 .

[99]  B. H. Pillow.  Development of Children's Understanding of Cognitive Activities , 2008, The Journal of genetic psychology.

[100]  Piers Steel,et al.  Comparing meta-analytic moderator estimation techniques under realistic conditions. , 2002, The Journal of applied psychology.

[101]  H. Forssberg,et al.  Computerized training of working memory in children with ADHD--a randomized, controlled trial. , 2005, Journal of the American Academy of Child and Adolescent Psychiatry.

[102]  M. J. Emerson,et al.  The Unity and Diversity of Executive Functions and Their Contributions to Complex “Frontal Lobe” Tasks: A Latent Variable Analysis , 2000, Cognitive Psychology.

[103]  E. Walker,et al.  Diagnostic and Statistical Manual of Mental Disorders , 2013 .

[104]  K. Scheffler,et al.  Effects of methylphenidate on working memory functioning in children with attention deficit/hyperactivity disorder. , 2009, European journal of paediatric neurology : EJPN : official journal of the European Paediatric Neurology Society.

[105]  Alan Baddeley,et al.  Is the word length effect in STM entirely attributable to output delay? Evidence from serial recognition , 2002, The Quarterly journal of experimental psychology. A, Human experimental psychology.

[106]  R. Barkley.  Behavioral inhibition, sustained attention, and executive functions: constructing a unifying theory of ADHD. , 1997, Psychological bulletin.

[107]  G. Bohlin,et al.  Developmental change in the relation between executive functions and symptoms of ADHD and co-occurring behaviour problems , 2006 .

[108]  Klaus P. Ebmeier,et al.  Pattern of impaired working memory during major depression. , 2006, Journal of affective disorders.

[109]  S. Calhoun,et al.  WISC-IV and WISC-III Profiles in Children With ADHD , 2006, Journal of attention disorders.

[110]  E. Harvey,et al.  Predicting attention-deficit/hyperactivity disorder and oppositional defiant disorder from preschool diagnostic assessments. , 2009, Journal of consulting and clinical psychology.

[111]  Monika Althaus,et al.  ERP correlates of selective attention and working memory capacities in children with ADHD and/or PDD-NOS , 2009, Clinical Neurophysiology.

[112]  J. Jonides,et al.  Dissociating verbal and spatial working memory using PET. , 1996, Cerebral cortex.

[113]  C. Karatekin.  A test of the integrity of the components of Baddeley's model of working memory in attention-deficit/hyperactivity disorder (ADHD). , 2004, Journal of child psychology and psychiatry, and allied disciplines.

[114]  Joseph S. Raiker,et al.  Working Memory Deficits and Social Problems in Children with ADHD , 2011, Journal of abnormal child psychology.

[115]  B. Pennington,et al.  Validity of the Executive Function Theory of Attention-Deficit/Hyperactivity Disorder: A Meta-Analytic Review , 2005, Biological Psychiatry.

[116]  Randall W. Engle,et al.  Short-term memory, working memory, and verbal abilities: How do they relate? , 1991 .

[117]  G. C. Fisher,et al.  Deficits in long-term memory are not characteristic of ADHD. Attention Deficit Hyperactivity Disorder. , 1998, Journal of clinical and experimental neuropsychology.

[118]  A. Mathews,et al.  Restriction of working memory capacity during worry. , 2008, Journal of abnormal psychology.

[119]  E. Willcutt,et al.  Instability of the DSM-IV Subtypes of ADHD from preschool through elementary school. , 2005, Archives of general psychiatry.

[120]  K. Zakzanis,et al.  Statistics to tell the truth, the whole truth, and nothing but the truth: formulae, illustrative numerical examples, and heuristic interpretation of effect size analyses for neuropsychological researchers. , 2001, Archives of clinical neuropsychology : the official journal of the National Academy of Neuropsychologists.

[121]  David Wechsler,et al.  Manual for the Wechsler intelligence scale for children , 1974 .

[122]  S. Hogg-Johnson,et al.  A meta-analysis of working memory impairments in children with attention-deficit/hyperactivity disorder. , 2005, Journal of the American Academy of Child and Adolescent Psychiatry.

[123]  S. Faraone,et al.  The Massachusetts General Hospital studies of gender influences on attention-deficit/hyperactivity disorder in youth and relatives. , 2004, The Psychiatric clinics of North America.

[124]  R. Overton,et al.  A comparison of fixed-effects and mixed (random-effects) models for meta-analysis tests of moderator , 1998 .

[125]  C. Cornoldi,et al.  Working Memory Interference Control Deficit in Children Referred by Teachers for ADHD Symptoms , 2001, Child neuropsychology : a journal on normal and abnormal development in childhood and adolescence.

[126]  Maria Chiara Passolunghi,et al.  Selective Effect of Inhibition of Literal or Numerical Irrelevant Information in Children With Attention Deficit Hyperactivity Disorder (ADHD) or Arithmetic Learning Disorder (ALD) , 2005, Developmental neuropsychology.

[127]  J. Rucklidge,et al.  An Investigation into the Relationship Among ADHD Symptomatology, Creativity, and Neuropsychological Functioning in Children , 2006, Child neuropsychology : a journal on normal and abnormal development in childhood and adolescence.

[128]  Andy P Field,et al.  How to do a meta-analysis. , 2010, The British journal of mathematical and statistical psychology.

[129]  David Baddeley,et al.  4D Super-Resolution Microscopy with Conventional Fluorophores and Single Wavelength Excitation in Optically Thick Cells and Tissues , 2011, PloS one.

[130]  T. Mexia,et al.  Author ' s personal copy , 2009 .

[131]  I. Mammarella,et al.  Spatial and visual working memory ability in children with difficulties in arithmetic word problem solving , 2010 .

[132]  B. Ambridge,et al.  The structure of working memory from 4 to 15 years of age. , 2004, Developmental psychology.

[133]  M. Korkman,et al.  Effects of Age on Neurocognitive Measures of Children Ages 5 to 12: A Cross-Sectional Study on 800 Children From the United States , 2001, Developmental neuropsychology.

[134]  L. Haataja,et al.  Elements of Working Memory as Predictors of Goal-Setting Skills in Children With Attention-Deficit/ Hyperactivity Disorder , 2010, Journal of learning disabilities.

[135]  John Suckling,et al.  A Longitudinal Functional Magnetic Resonance Imaging Study of Verbal Working Memory in Depression After Antidepressant Therapy , 2007, Biological Psychiatry.

[136]  D. Hommer,et al.  Eye movement task related to frontal lobe functioning in children with attention deficit disorder. , 1994, Journal of the American Academy of Child and Adolescent Psychiatry.

[137]  Susanne M. Jaeggi,et al.  Author's Personal Copy Behavioural Brain Research the Effects of Working Memory Resource Depletion and Training on Sensorimotor Adaptation , 2022 .

[138]  I. Gottesman,et al.  The endophenotype concept in psychiatry: etymology and strategic intentions. , 2003, The American journal of psychiatry.

[139]  Nikos Makris,et al.  Sex differences in the functional neuroanatomy of working memory in adults with ADHD. , 2010, The American journal of psychiatry.

[140]  R. Tannock,et al.  Behavioral and Brain Functions , 2007 .

[141]  Nelson Cowan,et al.  The development of memory in childhood , 1997 .

[142]  M. Place,et al.  Investigating the Relationship Between Attention and Working Memory in Clinical and Community Samples , 2010, Child neuropsychology : a journal on normal and abnormal development in childhood and adolescence.