Effects of distraction on pain perception: magneto- and electro-encephalographic studies.

After a painful CO2 laser stimulation to the skin, the magnetoencephalography (MEG) response (164 ms in average peak latency) was not affected by distraction, but the sequential electroencephalography (EEG) responses (240-340 ms), probably generated by a summation of activities in multiple areas, were markedly affected. We suspect that the MEG response, whose dipole is estimated in the bilateral second somatosensory cortex (SII) and insula, reflects the primary activities of pain in humans.

[1]  R. Treede,et al.  Laser-evoked cerebral potentials in the assessment of cutaneous pain sensitivity in normal subjects and patients. , 1991, Revue neurologique.

[2]  L. Arendt-Nielsen Characteristics, detection, and modulation of laser‐evoked vertex potentials , 1994, Acta anaesthesiologica Scandinavica. Supplementum.

[3]  R. Kakigi,et al.  Estimation of conduction velocity of Aδ fibers in humans , 1991 .

[4]  R. Treede,et al.  Nerve fibre discharges, cerebral potentials and sensations induced by CO2 laser stimulation. , 1984, Human neurobiology.

[5]  R. Kakigi,et al.  Pain-related somatosensory evoked magnetic fields. , 1995, Electroencephalography and Clinical Neurophysiology.

[6]  H Suzuki,et al.  Human cortical area responding to stimuli in apparent motion , 1997, Neuroreport.

[7]  K L Casey,et al.  Variability of laser-evoked potentials: attention, arousal and lateralized differences. , 1993, Electroencephalography and clinical neurophysiology.

[8]  K. Reinikainen,et al.  Neuromagnetic localization of cortical activity evoked by painful dental stimulation in man , 1983, Neuroscience Letters.

[9]  D. Yarnitsky,et al.  Pain-evoked potentials: what do they really measure? , 1996, Electroencephalography and clinical neurophysiology.

[10]  H Shibasaki,et al.  Estimation of conduction velocity of the spino-thalamic tract in man. , 1991, Electroencephalography and clinical neurophysiology.

[11]  F. Mauguière,et al.  Association and dissociation between laser‐evoked potentials and pain perception , 1997, Neuroreport.

[12]  H Shibasaki,et al.  Pain-related and cognitive components of somatosensory evoked potentials following CO2 laser stimulation in man. , 1995, Electroencephalography and clinical neurophysiology.

[13]  Pain-related brain responses following CO2 laser stimulation: magnetoencephalographic studies. , 1996, Electroencephalography and clinical neurophysiology. Supplement.

[14]  R. Treede,et al.  Laser-evoked potentials: exogenous and endogenous components. , 1996, Electroencephalography and clinical neurophysiology.

[15]  R. Kakigi,et al.  Pain-related magnetic fields following painful CO2 laser stimulation in man , 1995, Neuroscience Letters.

[16]  V. Jousmäki,et al.  Right-hemisphere preponderance of responses to painful CO2 stimulation of the human nasal mucosa , 1997, PAIN.