Associations of components of adult height with coronary heart disease in postmenopausal women: the British women’s heart and health study

Objective: To assess the associations between components of adult height and coronary heart disease (CHD) in postmenopausal women. Methods: Cross sectional analysis of 4286 women randomly selected from 23 British towns. The association of components of adult height with prevalent CHD (n  =  694) were assessed. Results: Shorter stature, shorter leg length, and trunk length were all associated with CHD in age adjusted analyses. The association between trunk length and CHD was attenuated to the null with adjustment for smoking. The leg length–CHD association was independent of smoking, socioeconomic position in childhood and adulthood, birth weight, and other potential confounders. Insulin resistance did not appear to be an important mediating factor in the association between leg length and CHD. After full adjustment for all potential confounding factors the odds ratio (95% confidence interval) of CHD for a 1 SD (4.3 cm) increase in leg length was 0.84 (0.77 to 0.93) and the odds ratio for a 1 SD (0.05) increase in the leg to trunk ratio was 0.85 (0.79 to 0.95). Conclusions: The specific association between leg length and CHD suggests that early life environmental exposures that influence skeletal growth also influence CHD risk in later life.

[1]  D. Lawlor,et al.  Geographical variation in cardiovascular disease, risk factors, and their control in older women: British Women's Heart and Health Study , 2003, Journal of epidemiology and community health.

[2]  G. Watt,et al.  Associations of height, leg length, and lung function with cardiovascular risk factors in the Midspan Family Study , 2003, Journal of epidemiology and community health.

[3]  Nancy R Cook,et al.  C-Reactive Protein, the Metabolic Syndrome, and Risk of Incident Cardiovascular Events: An 8-Year Follow-Up of 14 719 Initially Healthy American Women , 2003, Circulation.

[4]  D. Kuh,et al.  A life course approach to women's health. , 2002 .

[5]  D. Lawlor,et al.  The association between components of adult height and Type II diabetes and insulin resistance: British Women's Heart and Health Study , 2002, Diabetologia.

[6]  G. Smith,et al.  Association between Breast-Feeding and Growth in Childhood through to Adulthood , 2002 .

[7]  D. Gunnell.  Can adult anthropometry be used as a 'biomarker' for prenatal and childhood exposures? , 2002, International journal of epidemiology.

[8]  T. Cole,et al.  Leg and trunk length at 43 years in relation to childhood health, diet and family circumstances; evidence from the 1946 national birth cohort. , 2002, International journal of epidemiology.

[9]  Y. Ben-Shlomo,et al.  A life course approach to chronic disease epidemiology: conceptual models, empirical challenges and interdisciplinary perspectives , 2002 .

[10]  P. Elwood,et al.  Height, body mass index, and survival in men with coronary disease: follow up of the diet and reinfarction trial (DART) , 2002, Journal of epidemiology and community health.

[11]  R. Beaglehole,et al.  The real contribution of the major risk factors to the coronary epidemics: time to end the "only-50%" myth. , 2001, Archives of internal medicine.

[12]  P. Elwood,et al.  Leg length, insulin resistance, and coronary heart disease risk: The Caerphilly Study , 2001, Journal of epidemiology and community health.

[13]  J. Muller,et al.  Height is not associated with long-term survival after acute myocardial infarction. , 2001, American heart journal.

[14]  A. Goldberg,et al.  Limited value of the homeostasis model assessment to predict insulin resistance in older men with impaired glucose tolerance. , 2001, Diabetes care.

[15]  D. Barker.  Early growth and cardiovascular disease , 1999, Archives of disease in childhood.

[16]  J. Yudkin.  Abnormalities of coagulation and fibrinolysis in insulin resistance. Evidence for a common antecedent? , 1999, Diabetes Care.

[17]  A. McConnachie,et al.  Permanent effects of maternal smoking on offsprings' lung function , 1998, The Lancet.

[18]  J. Sterne,et al.  Birth weight, childhood lower respiratory tract infection, and adult lung function , 1998, Thorax.

[19]  T. Peters,et al.  Socio-economic and dietary influences on leg length and trunk length in childhood: a reanalysis of the Carnegie (Boyd Orr) survey of diet and health in prewar Britain (1937-39). , 1998, Paediatric and perinatal epidemiology.

[20]  T. Peters,et al.  Childhood leg length and adult mortality: follow up of the Carnegie (Boyd Orr) Survey of Diet and Health in Pre-war Britain. , 1998, Journal of epidemiology and community health.

[21]  G. Smith,et al.  Insulin resistance syndrome and childhood social conditions , 1997, The Lancet.

[22]  J. Manson,et al.  Height and the risk of cardiovascular disease in women. , 1995, American journal of epidemiology.

[23]  W. Gerver,et al.  Relationship between height, sitting height and subisehial leg length in Dutch children: presentation of normal values , 1995, Acta paediatrica.

[24]  D. Strachan,et al.  Adult height and mortality in London: early life, socioeconomic confounding, or shrinkage? , 1995, Journal of epidemiology and community health.

[25]  M. Røder,et al.  Enzyme immunoassay for intact human insulin in serum or plasma. , 1993, Clinical chemistry.

[26]  D. Strachan.  Ventilatory function, height, and mortality among lifelong non-smokers. , 1992, Journal of epidemiology and community health.

[27]  S. Shapiro,et al.  Stature and the risk of myocardial infarction in women. , 1990, American journal of epidemiology.

[28]  O. P. Gray,et al.  Growth of children from 0-5 years: with special reference to mother's smoking in pregnancy. , 1987, Annals of human biology.

[29]  R. Turner,et al.  Homeostasis model assessment: insulin resistance and β-cell function from fasting plasma glucose and insulin concentrations in man , 1985, Diabetologia.

[30]  E. Schoen,et al.  Factors influencing length at birth and height at five years. , 1974, Pediatrics.

[31]  H. Goldstein.  Factors influencing the height of seven year old children--results from the National Child Development Study. , 1971, Human biology.

[32]  J M Tanner,et al.  Increase in length of leg relative to trunk in Japanese children and adults from 1957 to 1977: comparison with British and with Japanese Americans. , 1982, Annals of human biology.

[33]  Nomenclature and criteria for diagnosis of ischemic heart disease. Report of the Joint International Society and Federation of Cardiology/World Health Organization task force on standardization of clinical nomenclature. , 1979, Circulation.