NGF is Induced by Lidocaine in Human Skin Fibroblast Cells In Vitro.
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We incubated skin fibroblasts with various concentrations of lidocaine for 3, 24, and 48 hours and found that the NGF mRNA expression levels significantly increased after incubation for 3 hours, indicating that the incubation for 3 hours activated the signaling that induce the NGF mRNA expression.