Improving technology for molecular imaging with ultrasound

Ultrasonic molecular imaging is a nascent field where the application of targeted contrast agents permits assessment of molecular changes in physiology. This is in contrast to the traditional anatomical imaging applications of ultrasound. To date, ultrasonic molecular imaging has shown promise in detecting molecular markers associated with angiogenesis, inflammation, and thrombus. However, this new modality has been only slowly advancing, and is still largely limited to studies in animal models. This conference proceeding reviews several challenge areas where our group is improving technology to facilitate ultrasonic molecular imaging.

[1]  Paul A Dayton,et al.  Acoustic response from adherent targeted contrast agents. , 2006, The Journal of the Acoustical Society of America.

[2]  Paul A Dayton,et al.  The magnitude of radiation force on ultrasound contrast agents. , 2002, The Journal of the Acoustical Society of America.

[3]  K W Ferrara,et al.  Selective imaging of adherent targeted ultrasound contrast agents , 2007, Physics in medicine and biology.

[4]  Paul A Dayton,et al.  Tailoring the Size Distribution of Ultrasound Contrast Agents: Possible Method for Improving Sensitivity in Molecular Imaging , 2007, Molecular imaging.

[5]  John A Hossack,et al.  Enhanced targeting of ultrasound contrast agents using acoustic radiation force. , 2007, Ultrasound in medicine & biology.

[6]  T. Leighton The Acoustic Bubble , 1994 .

[7]  J. Hossack,et al.  Acoustic radiation force enhances targeted delivery of ultrasound contrast microbubbles: in vitro verification , 2005, IEEE Transactions on Ultrasonics, Ferroelectrics and Frequency Control.

[8]  S. Acton,et al.  Targeted ultrasound contrast agent for molecular imaging of inflammation in high-shear flow. , 2006, Contrast media & molecular imaging.

[9]  Jonathan R. Lindner,et al.  Noninvasive Assessment of Angiogenesis by Ultrasound and Microbubbles Targeted to &agr;v-Integrins , 2003, Circulation.

[10]  P. Dayton,et al.  Threshold of fragmentation for ultrasonic contrast agents. , 2001, Journal of biomedical optics.

[11]  A. Klibanov,et al.  Ligand-carrying gas-filled microbubbles: ultrasound contrast agents for targeted molecular imaging. , 2005, Bioconjugate chemistry.

[12]  Paul A. Dayton,et al.  Radiation-Force Assisted Targeting Facilitates Ultrasonic Molecular Imaging , 2004 .

[13]  Hairong Zheng,et al.  A sensitive ultrasonic imaging method for targeted contrast microbubble detection , 2008, 2008 30th Annual International Conference of the IEEE Engineering in Medicine and Biology Society.