A review on self-assembly in microfluidic devices

Self-assembly is a process that operates over a vast range of length and time scales. Microfluidic technology has been proven to be a powerful tool to manipulate micro- and nano-scale substrates with precise control over size and speed using various fluidic materials and properties. In this review, we discuss the current status of microfluidic technology in manipulating fluid dynamics and interfacial phenomena which influence self-assembly process and resulted structures. The self-assembled materials/structures were summarized and discussed as the sequence of the objective size at the micro-, nano- and molecular scale. Overall, microfluidics is becoming a useful tool to manipulate various fluids regarding to physical and chemical properties, being inherently suitable for self-assembly process control.

[1]  J. Eijkel,et al.  Microfluidic fabrication of responsive hierarchical microscale particles from macroscale materials and nanoscale particles , 2017 .

[2]  E. Wagner,et al.  Microfluidic self-assembly of folate-targeted monomolecular siRNA-lipid nanoparticles. , 2017, Nanoscale.

[3]  R. Ghodssi,et al.  Biofabrication of Tobacco mosaic virus-nanoscaffolded supercapacitors via temporal capillary microfluidics , 2017, Nanotechnology.

[4]  Ashutosh Chilkoti,et al.  Programming molecular self-assembly of intrinsically disordered proteins containing sequences of low complexity. , 2017, Nature chemistry.

[5]  James E. Baker,et al.  Recognition-mediated particle detection under microfluidic flow with waveguide-coupled 2D photonic crystals: towards integrated photonic virus detectors. , 2017, Lab on a chip.

[6]  W. Huck,et al.  Microfluidic Assembly of Monodisperse Vesosomes as Artificial Cell Models. , 2017, Journal of the American Chemical Society.

[7]  Z. Nie,et al.  Anisotropic Self-Assembly of Hairy Inorganic Nanoparticles. , 2017, Accounts of chemical research.

[8]  Yang Lan,et al.  Cucurbit[n]uril-Based Microcapsules Self-Assembled within Microfluidic Droplets: A Versatile Approach for Supramolecular Architectures and Materials , 2017, Accounts of chemical research.

[9]  S. Roth,et al.  Self-assembly of block copolymers via micellar intermediate states into vesicles on time scales from milliseconds to days , 2016 .

[10]  Fei Wang,et al.  Optical biosensor based on liquid crystal droplets for detection of cholic acid , 2016 .

[11]  T. Lodge,et al.  Multicompartment Micelles by Aqueous Self-Assembly of μ-A(BC)nMiktobrush Terpolymers , 2016, ACS omega.

[12]  T. Nisisako.  Recent advances in microfluidic production of Janus droplets and particles , 2016 .

[13]  Jianhong Xu,et al.  Self-Assembly Kinetics of Colloidal Particles inside Monodispersed Micro-Droplet and Fabrication of Anisotropic Photonic Crystal Micro-Particles , 2016 .

[14]  R. M. Parker,et al.  Hierarchical Self-Assembly of Cellulose Nanocrystals in a Confined Geometry , 2016, ACS nano.

[15]  M. Pshenichnikov,et al.  Dynamics of Molecular Aggregate Formation: Lab-on-a-chip 2D Spectroscopic Approach , 2016 .

[16]  Jiashu Sun,et al.  Microfluidics-mediated assembly of functional nanoparticles for cancer-related pharmaceutical applications. , 2016, Nanoscale.

[17]  Stephan Herminghaus,et al.  Vesicles-on-a-chip: A universal microfluidic platform for the assembly of liposomes and polymersomes , 2016, The European physical journal. E, Soft matter.

[18]  D. Amabilino,et al.  Milliseconds Make the Difference in the Far-from-Equilibrium Self-Assembly of Supramolecular Chiral Nanostructures. , 2016, Journal of the American Chemical Society.

[19]  P. Tabeling,et al.  Designing Colloidal Molecules with Microfluidics , 2016, Advanced science.

[20]  Maofa Ge,et al.  Amphiphilic Janus Particles Generated via a Combination of Diffusion‐Induced Phase Separation and Magnetically Driven Dewetting and Their Synergistic Self‐Assembly , 2016, Advanced materials.

[21]  Yang Lan,et al.  Microfluidic Droplet-Facilitated Hierarchical Assembly for Dual Cargo Loading and Synergistic Delivery , 2016, ACS applied materials & interfaces.

[22]  Wei Zhao,et al.  On micro-electrokinetic scalar turbulence in microfluidics at a low Reynolds number. , 2016, Lab on a chip.

[23]  S. Tsai,et al.  Microfluidic magnetic self-assembly at liquid-liquid interfaces. , 2016, Soft matter.

[24]  P. Garstecki,et al.  Microfluidic platform for reproducible self-assembly of chemically communicating droplet networks with predesigned number and type of the communicating compartments. , 2016, Lab on a chip.

[25]  M. Stevens,et al.  Assembly of emulsion droplets into fibers by microfluidic wet spinning , 2016 .

[26]  Jean-Baptiste Salmon,et al.  Gold Nanooctahedra with Tunable Size and Microfluidic-Induced 3D Assembly for Highly Uniform SERS-Active Supercrystals , 2015 .

[27]  T. White,et al.  Programmable and adaptive mechanics with liquid crystal polymer networks and elastomers. , 2015, Nature materials.

[28]  G. Urban,et al.  Self-assembled magnetic bead chains for sensitivity enhancement of microfluidic electrochemical biosensor platforms. , 2015, Lab on a chip.

[29]  A. Abou-Hassan,et al.  Easy-to-Assemble and Adjustable Coaxial Flow-Focusing Microfluidic Device for Generating Controllable Water/Oil/Water Double Emulsions: Toward Templating Giant Liposomes with Different Properties , 2015, Journal of Flow Chemistry.

[30]  N. Katsonis,et al.  Superstructures of chiral nematic microspheres as all-optical switchable distributors of light , 2015, Scientific Reports.

[31]  C. Sukenik,et al.  An off-the-shelf integrated microfluidic device comprising self-assembled monolayers for protein array experiments. , 2015, Biomicrofluidics.

[32]  T. Fukuda,et al.  Magnetic assembly of microfluidic spun alginate microfibers for fabricating three-dimensional cell-laden hydrogel constructs , 2015 .

[33]  Lei Wang,et al.  Continuous Microfluidic Self-Assembly of Hybrid Janus-Like Vesicular Motors: Autonomous Propulsion and Controlled Release. , 2015, Small.

[34]  O. Deshmukh,et al.  Interfacial Assembly of Surfactant-Decorated Nanoparticles: On the Rheological Description of a Colloidal 2D Glass. , 2015, Langmuir : the ACS journal of surfaces and colloids.

[35]  N. Hassan,et al.  Droplet Liquid/Liquid Interfaces Generated in a Microfluidic Device for Assembling Janus Inorganic Nanohybrids , 2015 .

[36]  A. Hütten,et al.  DNA‐Mediated Stabilization of Self‐Assembling Bead Monolayers for Microfluidic Applications , 2015 .

[37]  V. Garbin,et al.  Ultrafast desorption of colloidal particles from fluid interfaces , 2015, Proceedings of the National Academy of Sciences.

[38]  N. Abbott,et al.  Nanoparticle self-assembly at the interface of liquid crystal droplets , 2015, Proceedings of the National Academy of Sciences.

[39]  W. Wang,et al.  Plug-n-play microfluidic systems from flexible assembly of glass-based flow-control modules. , 2015, Lab on a chip.

[40]  Yong Zhang,et al.  Sustained release of hydrophobic drugs by the microfluidic assembly of multistage microgel/poly (lactic-co-glycolic acid) nanoparticle composites. , 2015, Biomicrofluidics.

[41]  P. Bolhuis,et al.  Self-assembly of microcapsules via colloidal bond hybridization and anisotropy , 2015, Nature.

[42]  Z. Geng,et al.  Microfluidics-Based Self-Assembly of Amphiphilic Random Copolymer P(St-ran-DM) , 2015 .

[43]  R. S. Zola,et al.  Light-directing omnidirectional circularly polarized reflection from liquid-crystal droplets. , 2015, Angewandte Chemie.

[44]  Su Chen,et al.  Microfluidic assembly of uniform fluorescent microbeads from quantum‐dot‐loaded fluorine‐containing microemulsion , 2014 .

[45]  Nikunjkumar R. Visaveliya,et al.  Single-step microfluidic synthesis of various nonspherical polymer nanoparticles via in situ assembling: dominating role of polyelectrolytes molecules. , 2014, ACS applied materials & interfaces.

[46]  E. S. Kooij,et al.  Shape-induced separation of nanospheres and aligned nanorods. , 2014, Langmuir : the ACS journal of surfaces and colloids.

[47]  Luke P. Lee,et al.  Microfluidic bead-based diodes with targeted circular microchannels for low Reynolds number applications. , 2014, Lab on a chip.

[48]  Rosiane Lopes da Cunha,et al.  Y- and T-junction microfluidic devices: effect of fluids and interface properties and operating conditions , 2014 .

[49]  JungHyun Noh,et al.  Tuneable multicoloured patterns from photonic cross-communication between cholesteric liquid crystal droplets , 2014 .

[50]  L. Capretto,et al.  Microfluidic and lab-on-a-chip preparation routes for organic nanoparticles and vesicular systems for nanomedicine applications. , 2013, Advanced drug delivery reviews.

[51]  Howard A Stone,et al.  An "off-the-shelf" capillary microfluidic device that enables tuning of the droplet breakup regime at constant flow rates. , 2013, Lab on a chip.

[52]  Yuanjin Zhao,et al.  Microfluidic generation of magnetoresponsive Janus photonic crystal particles. , 2013, Nanoscale.

[53]  Chaoyang Wang,et al.  Vesicular self-assembly of colloidal amphiphiles in microfluidics. , 2013, ACS applied materials & interfaces.

[54]  Erfan Dashtimoghadam,et al.  Microfluidic self-assembly of polymeric nanoparticles with tunable compactness for controlled drug delivery , 2013 .

[55]  Y. Takanishi,et al.  Controlled Fabrication and Photonic Structure of Cholesteric Liquid Crystalline Shells , 2013, Advanced materials.

[56]  J. Hao,et al.  Self-assembly and accurate preparation of Au nanoparticles in the aqueous solution of a peptide A6D and a zwitterionic C14DMAO , 2013 .

[57]  Albert van den Berg,et al.  Large area metal nanowire arrays with tunable sub-20 nm nanogaps. , 2013, ACS nano.

[58]  Zuleykhan Tomova,et al.  Hydrodynamically driven self-assembly of giant vesicles of metal nanoparticles for remote-controlled release. , 2013, Angewandte Chemie.

[59]  Jincheng Li,et al.  One-step packing of anti-voltage photonic crystals into microfluidic channels for ultra-fast separation of amino acids and peptides. , 2013, Lab on a chip.

[60]  Mohammad Mahdi Hasani-Sadrabadi,et al.  Microfluidic assisted self-assembly of chitosan based nanoparticles as drug delivery agents. , 2013, Lab on a chip.

[61]  Charles N. Baroud,et al.  Droplet microfluidics driven by gradients of confinement , 2013, Proceedings of the National Academy of Sciences.

[62]  Zhengdong Cheng,et al.  Uniform yeast cell assembly via microfluidics. , 2012, Biomicrofluidics.

[63]  K. Knudsen,et al.  Guided self-assembly of nanostructured titanium oxide , 2012, Nanotechnology.

[64]  R. Zentel,et al.  One-piece micropumps from liquid crystalline core-shell particles , 2012, Nature Communications.

[65]  M. Jamal,et al.  Differentially photo-crosslinked polymers enable self-assembling microfluidics. , 2011, Nature communications.

[66]  David Sinton,et al.  Flow-directed block copolymer micelle morphologies via microfluidic self-assembly. , 2011, Journal of the American Chemical Society.

[67]  Hongmin Ma,et al.  Ordered patterns and structures via interfacial self-assembly: superlattices, honeycomb structures and coffee rings. , 2011, Chemical Society reviews.

[68]  W. Bentley,et al.  Biocompatible multi-address 3D cell assembly in microfluidic devices using spatially programmable gel formation. , 2011, Lab on a chip.

[69]  Fabian J. Eber,et al.  Inducible site-selective bottom-up assembly of virus-derived nanotube arrays on RNA-equipped wafers. , 2011, ACS nano.

[70]  Sunghoon Kwon,et al.  Three-dimensional fluidic self-assembly by axis translation of two-dimensionally fabricated microcomponents in railed microfluidics. , 2011, Small.

[71]  Charles N. Baroud,et al.  Rails and anchors: guiding and trapping droplet microreactors in two dimensions. , 2011, Lab on a chip.

[72]  B. Paegel,et al.  Stepwise Synthesis of Giant Unilamellar Vesicles on a Microfluidic Assembly Line , 2011, Journal of the American Chemical Society.

[73]  Daeyeon Lee,et al.  Gel‐Immobilized Colloidal Crystal Shell with Enhanced Thermal Sensitivity at Photonic Wavelengths , 2010, Advanced materials.

[74]  Feng Guo,et al.  A digital microfluidic droplet generator produces self-assembled supramolecular nanoparticles for targeted cell imaging , 2010, Nanotechnology.

[75]  Jinying Yuan,et al.  Voltage-responsive vesicles based on orthogonal assembly of two homopolymers. , 2010, Journal of the American Chemical Society.

[76]  J. Hao,et al.  Complex fluids of poly(oxyethylene) monoalkyl ether nonionic surfactants. , 2010, Chemical reviews.

[77]  R. Langer,et al.  Single-step assembly of homogenous lipid-polymeric and lipid-quantum dot nanoparticles enabled by microfluidic rapid mixing. , 2010, ACS nano.

[78]  Wyatt N Vreeland,et al.  Controlled self-assembly of monodisperse niosomes by microfluidic hydrodynamic focusing. , 2010, Langmuir : the ACS journal of surfaces and colloids.

[79]  Jan C.T. Eijkel,et al.  Capillary instability, squeezing, and shearing in head-on microfluidic devices , 2009 .

[80]  Wook Park,et al.  Sorting directionally oriented microstructures using railed microfluidics. , 2009, Lab on a chip.

[81]  Zhengzheng Fei,et al.  Delivery of polyethylenimine/DNA complexes assembled in a microfluidics device. , 2009, Molecular pharmaceutics.

[82]  P. Tabeling,et al.  Droplet breakup in microfluidic T-junctions at small capillary numbers , 2009 .

[83]  Lingling Shui,et al.  Interfacial tension controlled W/O and O/W 2-phase flows in microchannel. , 2009, Lab on a chip.

[84]  Len M. Pismen,et al.  Breakup of drops in a microfluidic T junction , 2009 .

[85]  Craig Priest,et al.  Microfluidic polymer multilayer adsorption on liquid crystal droplets for microcapsule synthesis. , 2008, Lab on a chip.

[86]  Wook Park,et al.  Guided and fluidic self-assembly of microstructures using railed microfluidic channels. , 2008, Nature materials.

[87]  Luke P. Lee,et al.  Microfluidic self-assembly of tumor spheroids for anticancer drug discovery , 2008, Biomedical microdevices.

[88]  Liang-Yin Chu,et al.  Controllable monodisperse multiple emulsions. , 2007, Angewandte Chemie.

[89]  J. Eijkel,et al.  Multiphase flow in micro- and nanochannels , 2007 .

[90]  S. D. Hudson,et al.  Rheo-optics of Equilibrium Polymer Solutions: Wormlike Micelles in Elongational Flow in a Microfluidic Cross-Slot , 2006 .

[91]  P. Bokov,et al.  Systèmes microfluidiques de particules magnétiques auto-assemblées; Application à la séparation d’ADN et à la digestion de protéines. , 2006 .

[92]  Wei Li,et al.  Janus and ternary particles generated by microfluidic synthesis: design, synthesis, and self-assembly. , 2006, Journal of the American Chemical Society.

[93]  M. Gijs,et al.  Manipulation of self-assembled structures of magnetic beads for microfluidic mixing and assaying. , 2004, Analytical chemistry.

[94]  Rustem F Ismagilov,et al.  Formation of droplets of alternating composition in microfluidic channels and applications to indexing of concentrations in droplet-based assays. , 2004, Analytical chemistry.

[95]  R. Adrian,et al.  Transition from laminar to turbulent flow in liquid filled microtubes , 2004 .

[96]  Wyatt N Vreeland,et al.  Controlled vesicle self-assembly in microfluidic channels with hydrodynamic focusing. , 2004, Journal of the American Chemical Society.

[97]  H. Girault,et al.  Reversible voltage-induced assembly of au nanoparticles at liquid/liquid interfaces. , 2004, Journal of the American Chemical Society.

[98]  D. Y. Wang,et al.  Flow and fracture in drying nanoparticle suspensions. , 2003, Physical review letters.

[99]  Otto Zhou,et al.  Assembly of 1D Nanostructures into Sub‐micrometer Diameter Fibrils with Controlled and Variable Length by Dielectrophoresis , 2003 .

[100]  Philip Huie,et al.  Building thick photoresist structures from the bottom up , 2003 .

[101]  D. Nelson.  Toward a Tetravalent Chemistry of Colloids , 2002, cond-mat/0206552.

[102]  G. Whitesides,et al.  Self-Assembly at All Scales , 2002, Science.

[103]  S. Quake,et al.  Dynamic pattern formation in a vesicle-generating microfluidic device. , 2001, Physical review letters.

[104]  D. Chowdhury,et al.  A microscopic model of gemini surfactants: self-assemblies in water and at air-water interface , 1997, cond-mat/9708082.

[105]  Arash Nikoubashman,et al.  Self-assembly of colloidal micelles in microfluidic channels. , 2016, Soft matter.

[106]  R. Ulijn,et al.  Biocatalytic self-assembly of nanostructured peptide microparticles using droplet microfluidics. , 2014, Small.