Roles of hepatocyte growth factor (HGF) activator and HGF activator inhibitor in the pericellular activation of HGF/scatter factor

[1]  H. Itoh,et al.  Expression of Hepatocyte Growth Factor Activator Inhibitor Type 2 (HAI-2) in Human Testis: Identification of a Distinct Transcription Start Site for the HAI-2 Gene in Testis , 2002, Biological chemistry.

[2]  M. Takigawa,et al.  CD44 stimulation by fragmented hyaluronic acid induces upregulation and tyrosine phosphorylation of c-Met receptor protein in human chondrosarcoma cells. , 2002, Biochimica et biophysica acta.

[3]  S. Wahl,et al.  Matriptase/MT-SP1 is required for postnatal survival, epidermal barrier function, hair follicle development, and thymic homeostasis , 2002, Oncogene.

[4]  G. Merlino,et al.  Constitutive c-Met signaling through a nonautocrine mechanism promotes metastasis in a transgenic transplantation model. , 2002, Cancer research.

[5]  S. Nakahara,et al.  Prometastatic Effect ofN-Acetylglucosaminyltransferase V Is Due to Modification and Stabilization of Active Matriptase by Adding β1–6 GlcNAc Branching* , 2002, The Journal of Biological Chemistry.

[6]  K. Miyazawa,et al.  Functional Characterization of Kunitz Domains in Hepatocyte Growth Factor Activator Inhibitor Type 1* , 2002, The Journal of Biological Chemistry.

[7]  Baljit Singh,et al.  Expression of the serine protease matriptase and its inhibitor HAI-1 in epithelial ovarian cancer: correlation with clinical outcome and tumor clinicopathological parameters. , 2002, Clinical cancer research : an official journal of the American Association for Cancer Research.

[8]  B. Zbar,et al.  Dysregulation of Met receptor tyrosine kinase activity in invasive tumors. , 2002, The Journal of clinical investigation.

[9]  H. Itoh,et al.  Emerging multifunctional aspects of cellular serine proteinase inhibitors in tumor progression and tissue regeneration , 2002, Pathology international.

[10]  N. Kitamura,et al.  Mouse hepatocyte growth factor (HGF) activator inhibitor type 2 lacking the first Kunitz domain potently inhibits the HGF activator. , 2002, Biochemical and biophysical research communications.

[11]  S. Hirono,et al.  Expression of hepatocyte growth factor activator and hepatocyte growth factor activator inhibitor type 1 in human hepatocellular carcinoma. , 2001, Biochemical and biophysical research communications.

[12]  T. Iwanaga,et al.  A role for membrane-type serine protease (MT-SP1) in intestinal epithelial turnover. , 2001, Biochemical and biophysical research communications.

[13]  W. Jiang,et al.  Expression of hepatocyte growth factor/scatter factor, its activator, inhibitors and the c-Met receptor in human cancer cells. , 2001, International journal of oncology.

[14]  H. Itoh,et al.  Reduced expression of hepatocyte growth factor activator inhibitor type‐2/placental bikunin (HAI‐2/PB) in human glioblastomas: Implication for anti‐invasive role of HAI‐2/PB in glioblastoma cells , 2001, International journal of cancer.

[15]  U. Scherf,et al.  Identification of differentially expressed genes in hepatocellular carcinoma and metastatic liver tumors by oligonucleotide expression profiling , 2001, Cancer.

[16]  Paul Scherz,et al.  Functional analysis of secreted and transmembrane proteins critical to mouse development , 2001, Nature Genetics.

[17]  N. Kitamura,et al.  Mouse hepatocyte growth factor activator inhibitor type 1 (HAI-1) and type 2 (HAI-2)/placental bikunin genes and their promoters. , 2001, Biochimica et biophysica acta.

[18]  J. Barasch,et al.  Activation of Hepatocyte Growth Factor (HGF) by Endogenous HGF Activator Is Required for Metanephric Kidney Morphogenesis in Vitro * , 2001, The Journal of Biological Chemistry.

[19]  R. Dickson,et al.  Matriptase and HAI-1 are expressed by normal and malignant epithelial cells in vitro and in vivo. , 2001, The American journal of pathology.

[20]  R. Dickson,et al.  Regulation of the activity of matriptase on epithelial cell surfaces by a blood-derived factor. , 2001, European journal of biochemistry.

[21]  H. Itoh,et al.  Pericellular activation of hepatocyte growth factor/scatter factor (HGF/SF) in colorectal carcinomas: roles of HGF activator (HGFA) and HGFA inhibitor type 1 (HAI-1). , 2001, Human cell.

[22]  K. Miyazawa,et al.  Hepatocyte Growth Factor Activator Inhibitor Type 1 Is a Specific Cell Surface Binding Protein of Hepatocyte Growth Factor Activator (HGFA) and Regulates HGFA Activity in the Pericellular Microenvironment* , 2000, The Journal of Biological Chemistry.

[23]  H. Itoh,et al.  Localization of hepatocyte growth factor activator inhibitor type 1 in Langhans' cells of human placenta , 2000, Histochemistry and Cell Biology.

[24]  R. Dickson,et al.  Activation of Hepatocyte Growth Factor and Urokinase/Plasminogen Activator by Matriptase, an Epithelial Membrane Serine Protease* , 2000, The Journal of Biological Chemistry.

[25]  N. Kitamura,et al.  Activation of hepatocyte growth factor/scatter factor in colorectal carcinoma. , 2000, Cancer research.

[26]  Jennifer L. Harris,et al.  Cellular Localization of Membrane-type Serine Protease 1 and Identification of Protease-activated Receptor-2 and Single-chain Urokinase-type Plasminogen Activator as Substrates* , 2000, The Journal of Biological Chemistry.

[27]  N. Kitamura,et al.  Genomic structure and chromosomal localization of the human hepatocyte growth factor activator inhibitor type 1 and 2 genes. , 2000, European journal of biochemistry.

[28]  K. Miyazawa,et al.  Mouse hepatocyte growth factor activator gene: its expression not only in the liver but also in the gastrointestinal tract. , 2000, Biochimica et biophysica acta.

[29]  D. Stolz,et al.  Cross-talk between Epidermal Growth Factor Receptor and c-Met Signal Pathways in Transformed Cells* , 2000, The Journal of Biological Chemistry.

[30]  G. Merlino,et al.  Disassociation of Met-Mediated Biological Responses In Vivo: the Natural Hepatocyte Growth Factor/Scatter Factor Splice Variant NK2 Antagonizes Growth but Facilitates Metastasis , 2000, Molecular and Cellular Biology.

[31]  K. Nabeshima,et al.  Conserved expression of hepatocyte growth factor activator inhibitor type-2/placental bikunin in human colorectal carcinomas. , 2000, Cancer letters.

[32]  S. Mitsui,et al.  Hair cycle-dependent expression of hepatocyte growth factor (HGF) activator, other proteinases, and proteinase inhibitors correlates with the expression of HGF in rat hair follicles. , 1999, The journal of investigative dermatology. Symposium proceedings.

[33]  K. Matsumoto,et al.  Multiple sites of proteolytic cleavage to release soluble forms of hepatocyte growth factor activator inhibitor type 1 from a transmembrane form. , 1999, Journal of biochemistry.

[34]  C. Craik,et al.  Reverse biochemistry: use of macromolecular protease inhibitors to dissect complex biological processes and identify a membrane-type serine protease in epithelial cancer and normal tissue. , 1999, Proceedings of the National Academy of Sciences of the United States of America.

[35]  H. Dietz,et al.  Reversion of human glioblastoma malignancy by U1 small nuclear RNA/ribozyme targeting of scatter factor/hepatocyte growth factor and c-met expression. , 1999, Journal of the National Cancer Institute.

[36]  M. Seiki,et al.  Regulation of matrix metalloproteinase‐2 (MMP‐2) by hepatocyte growth factor/scatter factor (HGF/SF) in human glioma cells: HGF/SF enhances MMP‐2 expression and activation accompanying up‐regulation of membrane type‐1 MMP , 1999, International journal of cancer.

[37]  M. Johnson,et al.  Molecular Cloning of cDNA for Matriptase, a Matrix-degrading Serine Protease with Trypsin-like Activity* , 1999, The Journal of Biological Chemistry.

[38]  M. Johnson,et al.  Purification and Characterization of a Complex Containing Matriptase and a Kunitz-type Serine Protease Inhibitor from Human Milk* , 1999, The Journal of Biological Chemistry.

[39]  K. Nabeshima,et al.  Distribution of Hepatocyte Growth Factor Activator Inhibitor Type 1 (HAI-1) in Human Tissues: Cellular Surface Localization of HAI-1 in Simple Columnar Epithelium and Its Modulated Expression in Injured and Regenerative Tissues , 1999, The journal of histochemistry and cytochemistry : official journal of the Histochemistry Society.

[40]  N. Kitamura,et al.  Hepatocyte growth factor activator inhibitor type 2 lacking the first Kunitz-type serine proteinase inhibitor domain is a predominant product in mouse but not in human. , 1999, Biochemical and biophysical research communications.

[41]  M. Omata,et al.  Hepatocyte growth factor activator: a possible regulator of morphogenesis during fetal development of the rat gastrointestinal tract. , 1998, Biochemical and biophysical research communications.

[42]  N. Shimizu,et al.  Structural organization and chromosomal localization of the human hepatocyte growth factor activator gene--phylogenetic and functional relationship with blood coagulation factor XII, urokinase, and tissue-type plasminogen activator. , 1998, European journal of biochemistry.

[43]  N. Kitamura,et al.  Functional characterization of Kunitz domains in hepatocyte growth factor activator inhibitor type 2 , 1998, FEBS letters.

[44]  H. Kataoka,et al.  Up-regulation of vascular endothelial growth factor induced by hepatocyte growth factor/scatter factor stimulation in human glioma cells. , 1998, Biochemical and biophysical research communications.

[45]  Y. Itoyama,et al.  Inductions of hepatocyte growth factor and its activator in rat brain with permanent middle cerebral artery occlusion , 1998, Brain Research.

[46]  K. Nabeshima,et al.  Evaluation of hepatocyte growth factor activator inhibitor expression in normal and malignant colonic mucosa. , 1998, Cancer letters.

[47]  G. Merlino,et al.  NK1, a Natural Splice Variant of Hepatocyte Growth Factor/Scatter Factor, Is a Partial Agonist In Vivo , 1998, Molecular and Cellular Biology.

[48]  H. Friess,et al.  Cloning of a new Kunitz-type protease inhibitor with a putative transmembrane domain overexpressed in pancreatic cancer. , 1998, Biochimica et biophysica acta.

[49]  K. Matsumoto,et al.  Purification and Cloning of Hepatocyte Growth Factor Activator Inhibitor Type 2, a Kunitz-type Serine Protease Inhibitor* , 1997, The Journal of Biological Chemistry.

[50]  T Nakamura,et al.  Hepatocyte growth factor (HGF) as a tissue organizer for organogenesis and regeneration. , 1997, Biochemical and biophysical research communications.

[51]  K. Nabeshima,et al.  Analysis of tissue factor and tissue factor pathway inhibitor expression in human colorectal carcinoma cell lines and metastatic sublines to the liver , 1997, International journal of cancer.

[52]  J. Greve,et al.  Identification and Cloning of Human Placental Bikunin, a Novel Serine Protease Inhibitor Containing Two Kunitz Domains* , 1997, The Journal of Biological Chemistry.

[53]  S. Roczniak,et al.  Characterization of Placental Bikunin, a Novel Human Serine Protease Inhibitor* , 1997, The Journal of Biological Chemistry.

[54]  S. Scherer,et al.  Germline and somatic mutations in the tyrosine kinase domain of the MET proto-oncogene in papillary renal carcinomas , 1997, Nature Genetics.

[55]  K. Miyazawa,et al.  Hepatocyte Growth Factor Activator Inhibitor, a Novel Kunitz-type Serine Protease Inhibitor* , 1997, The Journal of Biological Chemistry.

[56]  L. Jin,et al.  Scatter factor stimulates tumor growth and tumor angiogenesis in human breast cancers in the mammary fat pads of nude mice. , 1997, Laboratory investigation; a journal of technical methods and pathology.

[57]  K. Miyazawa,et al.  Induction of hepatocyte growth factor activator messenger RNA in the liver following tissue injury and acute inflammation , 1997, Hepatology.

[58]  P. Comoglio,et al.  Overexpression and activation of hepatocyte growth factor/scatter factor in human non-small-cell lung carcinomas. , 1996, British Journal of Cancer.

[59]  D. Stolz,et al.  Presence of urokinase in serum-free primary rat hepatocyte cultures and its role in activating hepatocyte growth factor. , 1996, Cancer research.

[60]  K. Matsumoto,et al.  Emerging multipotent aspects of hepatocyte growth factor. , 1996, Journal of biochemistry.

[61]  G. V. Vande Woude,et al.  Enhanced tumorigenicity and invasion-metastasis by hepatocyte growth factor/scatter factor-met signalling in human cells concomitant with induction of the urokinase proteolysis network , 1996, Molecular and cellular biology.

[62]  K. Miyazawa,et al.  Activation of Hepatocyte Growth Factor in the Injured Tissues Is Mediated by Hepatocyte Growth Factor Activator (*) , 1996, The Journal of Biological Chemistry.

[63]  N. Rahimi,et al.  Identification of a hepatocyte growth factor autocrine loop in a murine mammary carcinoma. , 1996, Cell growth & differentiation : the molecular biology journal of the American Association for Cancer Research.

[64]  H. Tsubouchi,et al.  Concomitant expression of hepatocyte growth factor (HGF), HGF activator and c‐met genes in human glioma cells in vitro , 1995, FEBS letters.

[65]  Carmen Birchmeier,et al.  Essential role for the c-met receptor in the migration of myogenic precursor cells into the limb bud , 1995, Nature.

[66]  G. Michalopoulos,et al.  The many faces of hepatocyte growth factor: from hepatopoiesis to hematopoiesis , 1995, The Journal of cell biology.

[67]  T. Nakamura,et al.  Hepatocyte growth factor is the most potent endogenous stimulant of rabbit gastric epithelial cell proliferation and migration in primary culture. , 1995, The Journal of clinical investigation.

[68]  K. Miyazawa,et al.  Hepatocyte growth factor remains as an inactive single chain after partial hepatectomy or unilateral nephrectomy , 1995, FEBS letters.

[69]  K. Miyazawa,et al.  Activation of hepatocyte growth factor by two homologous proteases, blood-coagulation factor XIIa and hepatocyte growth factor activator. , 1995, European journal of biochemistry.

[70]  Tetsuo Noda,et al.  Placental defect and embryonic lethality in mice lacking hepatocyte growth factor/scatter factor , 1995, Nature.

[71]  M. Sharpe,et al.  Scatter factor/hepatocyte growth factor is essential for liver development , 1995, Nature.

[72]  P. Lollini,et al.  The Met/HGF receptor is over-expressed in human osteosarcomas and is activated by either a paracrine or an autocrine circuit. , 1995, Oncogene.

[73]  A. Bardelli,et al.  Biological Activation of pro-HGF (Hepatocyte Growth Factor) by Urokinase Is Controlled by a Stoichiometric Reaction (*) , 1995, The Journal of Biological Chemistry.

[74]  G. V. Vande Woude,et al.  Invasiveness and metastasis of NIH 3T3 cells induced by Met-hepatocyte growth factor/scatter factor autocrine stimulation. , 1994, Proceedings of the National Academy of Sciences of the United States of America.

[75]  T. Nakamura,et al.  Creation of an hepatocyte growth factor/scatter factor autocrine loop in carcinoma cells induces invasive properties associated with increased tumorigenicity. , 1994, Oncogene.

[76]  K. Miyazawa,et al.  Proteolytic activation of hepatocyte growth factor in response to tissue injury. , 1994, The Journal of biological chemistry.

[77]  K. Miyazawa,et al.  Activation of the zymogen of hepatocyte growth factor activator by thrombin. , 1993, The Journal of biological chemistry.

[78]  G. Michalopoulos,et al.  Activation of hepatocyte growth factor by the plasminogen activators uPA and tPA. , 1993, The American journal of pathology.

[79]  K. Miyazawa,et al.  Molecular cloning and sequence analysis of the cDNA for a human serine protease reponsible for activation of hepatocyte growth factor. Structural similarity of the protease precursor to blood coagulation factor XII. , 1993, The Journal of biological chemistry.

[80]  T. Nakamura,et al.  Proteolytic activation of a single-chain precursor of hepatocyte growth factor by extracellular serine-protease. , 1992, Biochemical and biophysical research communications.

[81]  W. Birchmeier,et al.  Extracellular proteolytic cleavage by urokinase is required for activation of hepatocyte growth factor/scatter factor. , 1992, The EMBO journal.

[82]  J. Rubin,et al.  Processing of hepatocyte growth factor to the heterodimeric form is required for biological activity , 1992, FEBS letters.

[83]  K. Miyazawa,et al.  Activation of hepatocyte growth factor by proteolytic conversion of a single chain form to a heterodimer. , 1992, The Journal of biological chemistry.

[84]  A. Bardelli,et al.  Scatter factor and hepatocyte growth factor are indistinguishable ligands for the MET receptor. , 1991, The EMBO journal.

[85]  W. Birchmeier,et al.  Evidence for the identity of human scatter factor and human hepatocyte growth factor. , 1991, Proceedings of the National Academy of Sciences of the United States of America.

[86]  S. Hirono,et al.  Purification and partial characterization of hepatocyte growth factor from plasma of a patient with fulminant hepatic failure. , 1988, The Journal of clinical investigation.

[87]  Toshikazu Nakamura,et al.  Purification and subunit structure of hepatocyte growth factor from rat platelets , 1987, FEBS letters.

[88]  Michael Stoker,et al.  Scatter factor is a fibroblast-derived modulator of epithelial cell mobility , 1987, Nature.

[89]  H. Dvorak Tumors: wounds that do not heal. Similarities between tumor stroma generation and wound healing. , 1986, The New England journal of medicine.

[90]  J. Kondo,et al.  A novel protease obtained from FBS-containing culture supernatant, that processes single chain form hepatocyte growth factor to two chain form in serum-free culture , 2006, Cytotechnology.

[91]  T. Taher,et al.  Cross-talk between CD44 and c-Met in B cells. , 1999, Current topics in microbiology and immunology.

[92]  Y. Matsushima,et al.  Production and activation of hepatocyte growth factor during the healing of rat gastric ulcers. , 1997, Digestion.