The Nature and Significance of Platelet Products in Human Plasma

Fresh plasma freed of intact platelets can be shown to contain minute particulate material (platelet‐dust) which can be separated by ultracentrifugation. Much of this material is rich in phospholipid and shows coagulant properties resembling those of Platelet Factor 3. The supernatant plasma, freed of these particles, shows a corresponding deficiency in Platelet Factor 3 activity.

[1]  E. Chargaff,et al.  The biological significance of the thromboplastic protein of blood. , 1946, The Journal of biological chemistry.

[2]  J. Fahey,et al.  Platelet extracts, fibrin formation and interaction of purified prothrombin and thromboplastin. , 1948, The American journal of physiology.

[3]  M. Paulssen,et al.  Significance of clotting factors in blood-platelets, in normal and pathological conditions. , 1951, Lancet.

[4]  F. Richards,et al.  The Use of the Gradient Tube for the Determination of Crystal Densities1a , 1952 .

[5]  M. Paulssen,et al.  Isolation and properties of the third clotting factor in blood-platelets. , 1952, Lancet.

[6]  J. Dacie,et al.  A Simple Method of Studying the Generation of Thrombin in Recalcified Plasma , 1953, Journal of clinical pathology.

[7]  P. Wolf.  A Modification for Routine Laboratory Use of Stefanini's Method of Estimating Factor V Activity in Human Oxalated Plasma , 1953, Journal of clinical pathology.

[8]  Differentiation of certain platelet factors in relation to blood coagulation. , 1954, Revue d'hematologie.

[9]  C. Hussey,et al.  THE CLOTTING ACTIVITY OF HUMAN ERYTHROCYTES: THEORETICAL AND CLINICAL IMPLICATIONS* , 1954, The American journal of the medical sciences.

[10]  C. Hougie.  The Activation of Platelets by Plasma , 1955, Revue belge de pathologie et de medecine experimentale.

[11]  J. Poole.  The Significance of Chylomicra in Blood Coagulation , 1955, British journal of haematology.

[12]  J. R. O'brien.  The Platelet‐like Activity of Serum. , 1955, British journal of haematology.

[13]  The Prothrombin Conversion Ratio , 1956, British journal of haematology.

[14]  P. Wolf.  Lipid Extracts of Platelets and Brain as Substitutes for Platelets in Coagulation Tests , 1956, British journal of haematology.

[15]  R. Biggs,et al.  An Attempt to Identify a Single Phospholipid Active in Blood Coagulation , 1957, British journal of haematology.

[16]  W. Pitney,et al.  A Rapid Screening Test for Disorders of Thromboplastin Generation , 1957, British journal of haematology.

[17]  G. R. Bartlett.  Phosphorus assay in column chromatography. , 1959, The Journal of biological chemistry.

[18]  B. Waaler.  Contact activation in the intrinsic blood clotting system; studies on a plasma product formed on contact with glass and similar surfaces. , 1959, Scandinavian journal of clinical and laboratory investigation.

[19]  P. Wolf.  Platelet Distribution and Survival in Plasma Clots and Thrombi , 1961, Thrombosis and Haemostasis.

[20]  D. Stanworth,et al.  Application of zone centrifugation to the study of normal and pathological human sera , 1961 .

[21]  Soothill Jf.  Estimation of eight serum proteins by a gel diffusion precipitin technique. , 1962 .

[22]  J. Soothill,et al.  An Investigation of Methods of Isolation of β2M1 Globulin (Syn.: Iota Protein, 19S γ Globulin, γ1 Macroglobulin, β2M Globulin) and its Association with Isoagglutinin Activity, together with Preliminary Observations on Other Macroglobulins of Slow Electrophoretic Mobility in Normal Human Serum , 1963 .

[23]  P. Wolf,et al.  Human antihaemophilic factor. The preparation in a hospital of a concentrate for clinical use. , 1963, Lancet.

[24]  K. Brinkhous,et al.  SOME PATHOGENETIC MECHANISMS OF WHITE THROMBUS FORMATION: AGGLUTINATION AND SELF-DESTRUCTION OF THE PLATELET. , 1963, Federation proceedings.

[25]  R. Macfarlane,et al.  The Activation and Consumption of Factor X in Recalcified Plasma , 1964, British journal of haematology.

[26]  A. Hellem,et al.  THE MECHANISM OF THE HEMOSTATIC FUNCTION OF BLOOD PLATELETS. , 1964, Acta haematologica.

[27]  R. Young,et al.  Change in Platelet Factor 3 as a Means of Demonstrating Immune Reactions Involving Platelets: Its Use as a Test for Quinidine‐Induced Thrombocytopenia , 1965, Transfusion.

[28]  T. Spaet,et al.  Studies on Platelet Factor‐3 Availability , 1965, British journal of haematology.

[29]  R. Macfarlane.  CHAPTER 13 – Hemostatic Mechanisms in Tissue Injury , 1965 .

[30]  A. J. Webber,et al.  Two Populations of Platelets , 1965, Nature.

[31]  P. Wolf,et al.  INVESTIGATION OF A QUANTITATIVE ANOMALY ENCOUNTERED IN THE ASSAY OF FIBRINOGEN BY IMMUNO-DIFFUSION. , 1965, Immunology.

[32]  F. Rodríguez-Erdmann,et al.  Intravascular activation of the clotting system with phospholipids. Production of the generalized Shwartzman reaction with platelet factor 3. , 1965, Blood.

[33]  A. Marcus,et al.  The role of lipids in blood coagulation. , 1966, Advances in lipid research.