Hepatitis B Surface Antigen Circulating Immune Complexes (HBsAg‐CICs) in Patients with Bleeding Disorders

Abstract. Approximately 90% of 67 multi‐transfused patients with bleeding disorders were positive either for anti‐HBs (85%) or HBsAg (4.5%). Using a polyethylene glycol trypsinization assay, we found HBsAg‐containing specific circulating immune complexes (HBsAg‐CICs) in 3 of the 57 HBsAg‐negative haemophiliacs possessing anti‐HBs. The occurrence of HBsAg‐CICs may be a regular event in the conversion phase of HBs infection. Circulating immune complexes as detected by the anticomplementary assay were found in 32 of the 67 (48%) patients.

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