A silicon microelectrode array for simultaneous recording and stimulation in the brain of behaving animals

This paper presents an eight-channel silicon neural probe with integrated CMOS circuitry designed for simultaneous recording and stimulation in the brain. The probe includes eight on-chip amplifiers that can be individually bypassed, allowing direct access to the indium sites for electrical stimulation. The on-probe amplifiers have a gain of 38.9dB, an upper cutoff frequency of 9.9 kHz, and an input referred noise of 9.2 /spl mu/Vrms from 100 Hz to 10 kHz. The low-frequency cutoff of the amplifier is tunable to allow the recording of field potentials and minimize stimulus artifact. The on-probe circuitry consumes 672 /spl mu/W from /spl plusmn/1.5 V supplies and occupies 2.02 mm/sup 2/ in 3 /spl mu/m features. In-vivo recordings have shown that the preamplifiers can record single-unit activity 1 ms after the onset of stimulation on sites as close as 20 /spl mu/m to the stimulating electrode. Further artifact suppression is achievable with precise tuning of the low-frequency amplifier cutoff.

[1]  Qing Bai,et al.  A high-yield microassembly structure for three-dimensional microelectrode arrays , 2000, IEEE Transactions on Biomedical Engineering.

[2]  Khalil Najafi,et al.  An Ultra-Thin Hermetic Package Utilizing Electroplated Gold , 2001 .

[3]  Kensall D. Wise,et al.  Silicon neural recording arrays with on-chip electronics for in-vivo data acquisition , 2002, 2nd Annual International IEEE-EMBS Special Topic Conference on Microtechnologies in Medicine and Biology. Proceedings (Cat. No.02EX578).

[4]  Reid R. Harrison,et al.  A low-power, low-noise CMOS amplifier for neural recording applications , 2002, 2002 IEEE International Symposium on Circuits and Systems. Proceedings (Cat. No.02CH37353).

[5]  J. Csicsvari,et al.  Mechanisms of Gamma Oscillations in the Hippocampus of the Behaving Rat , 2003, Neuron.

[6]  Yasuhiko Jimbo,et al.  A system for MEA-based multisite stimulation , 2003, IEEE Transactions on Biomedical Engineering.

[7]  K. Wise,et al.  A fully-integrated bandpass amplifier for extracellular neural recording , 2003, First International IEEE EMBS Conference on Neural Engineering, 2003. Conference Proceedings..

[8]  Highly parallel recordings of unit and local field potentials with active and passive neural probes in freely-moving animals. , 2003 .

[9]  Dawn M. Taylor,et al.  Cortical control of natural arm movement , 2003, First International IEEE EMBS Conference on Neural Engineering, 2003. Conference Proceedings..