Aluminium-adjuvanted vaccines transiently increase aluminium levels in murine brain tissue.

Aluminium is widely used as an adjuvant in human vaccines, and children can often receive up to 3.75 mg of parenteral aluminium during the first six months of life. We show that intraperitoneal injection of aluminium adsorbed vaccines into mice causes a transient rise in brain tissue aluminium levels peaking around the second and third day after injection. This rise is not seen in the saline control group of animals or with vaccine not containing aluminium. It is likely that aluminium is transported to the brain by the iron-binding protein transferrin and enters the brain via specific transferrin receptors.

[1]  J. Vanderhoof,et al.  Elevated plasma aluminum levels in normal infants receiving antacids containing aluminum. , 1991, Pediatrics.

[2]  J. Connor,et al.  Aluminum access to the brain: a role for transferrin and its receptor. , 1990, Proceedings of the National Academy of Sciences of the United States of America.

[3]  A. Freemont,et al.  Aluminium deposition in bone after contamination of drinking water supply , 1990, The Lancet.

[4]  M. Golub,et al.  Effects of aluminum on brain lipid peroxidation. , 1990, Toxicology letters.

[5]  C Osmond,et al.  GEOGRAPHICAL RELATION BETWEEN ALZHEIMER'S DISEASE AND ALUMINIUM IN DRINKING WATER , 1989, The Lancet.

[6]  J. Birchall,et al.  ALUMINIUM, CHEMICAL PHYSIOLOGY, AND ALZHEIMER'S DISEASE , 1988, The Lancet.

[7]  P. Altmann,et al.  ALUMINIUM CHELATION THERAPY IN DIALYSIS PATIENTS: EVIDENCE FOR INHIBITION OF HAEMOGLOBIN SYNTHESIS BY LOW LEVELS OF ALUMINIUM , 1988, The Lancet.

[8]  Martin Rb.  Citrate binding of Al3+ and Fe3+. , 1986 .

[9]  A. Lione.  More on aluminum in infants. , 1986, The New England journal of medicine.

[10]  B. Halliwell,et al.  Oxygen radicals and the nervous system , 1985, Trends in Neurosciences.

[11]  B. Halliwell,et al.  Aluminium salts accelerate peroxidation of membrane lipids stimulated by iron salts. , 1985, Biochimica et biophysica acta.

[12]  J. Lunec,et al.  Cerebral and ocular toxicity induced by desferrioxamine. , 1985, The Quarterly journal of medicine.

[13]  R. Garruto,et al.  Imaging of calcium and aluminum in neurofibrillary tangle-bearing neurons in parkinsonism-dementia of Guam. , 1984, Proceedings of the National Academy of Sciences of the United States of America.

[14]  A. Kastin,et al.  ALUMINIUM INCREASES PERMEABILITY OF THE BLOOD-BRAIN BARRIER TO LABELLED DSIP AND β-ENDORPHIN: POSSIBLE IMPLICATIONS FOR SENILE AND DIALYSIS DEMENTIA , 1983, The Lancet.

[15]  J. Savory,et al.  ALUMINIUM POISONING: DIALYSIS ENCEPHALOPATHY, OSTEOMALACIA, AND ANAEMIA , 1983, The Lancet.

[16]  F. Takayama,et al.  Effect of aluminum ingestion on lipid peroxidation in rats. , 1983, Chemical & pharmaceutical bulletin.

[17]  D. Perl,et al.  Alzheimer's disease: X-ray spectrometric evidence of aluminum accumulation in neurofibrillary tangle-bearing neurons. , 1980, Science.

[18]  M. Darani,et al.  HEPATITIS-B ANTIGEN IN VAGINAL SECRETIONS , 1974 .

[19]  N. Butler,et al.  Advantages of Aluminium Hydroxide Adsorbed Combined Diphtheria, Tetanus, and Pertussis Vaccines for the Immunization of Infants , 1969, British medical journal.

[20]  J. Klinowski,et al.  Alzheimer's disease: a pathogenic role for aluminosilicate-induced phagocytic free radicals. , 1989, Free radical research communications.

[21]  S. B. Furnass.  Seminal vitamin B-12 and sterility. , 1963, Lancet.