Fat‐Soluble Vitamins in Advanced CKD/ESKD: A Review

Patients requiring dialysis often experience a significant decline in their nutritional status through a combination of chronic disease, reduced appetite, and dietary restrictions, which places them at risk for vitamin deficiencies. The concept of vitamin deficiency has evolved from obvious deficiency states to the subtle effects that suboptimal intake may have on chronic disease prevalence or progression. The purpose of this study was to summarize the current state of knowledge regarding the status of the fat‐soluble vitamins (A, D, E, and K) in patients with chronic kidney disease receiving hemodialysis.

[1]  B. Jaber,et al.  Potential interaction between sevelamer and fat-soluble vitamins: a hypothesis. , 2012, American journal of kidney diseases : the official journal of the National Kidney Foundation.

[2]  L. Schurgers,et al.  Effect of vitamin K2 supplementation on functional vitamin K deficiency in hemodialysis patients: a randomized trial. , 2012, American journal of kidney diseases : the official journal of the National Kidney Foundation.

[3]  M. Sánchez-Niño,et al.  Undetectable serum calcidiol: not everything that glitters is gold , 2012, Clinical kidney journal.

[4]  P. Hill,et al.  Oral cholecalciferol decreases albuminuria and urinary TGF-β1 in patients with type 2 diabetic nephropathy on established renin-angiotensin-aldosterone system inhibition. , 2011, Kidney international.

[5]  E. Fernández,et al.  Vascular calcification and 25-hydroxyvitamin D levels in non-dialysis patients with chronic kidney disease stages 4 and 5. , 2011, Nephrology, dialysis, transplantation : official publication of the European Dialysis and Transplant Association - European Renal Association.

[6]  R. Recker,et al.  Vitamin D(3) is more potent than vitamin D(2) in humans. , 2011, The Journal of clinical endocrinology and metabolism.

[7]  A. Pfeiffer,et al.  Relation between retinol, retinol-binding protein 4, transthyretin and carotid intima media thickness. , 2010, Atherosclerosis.

[8]  John H. White Vitamin D as an inducer of cathelicidin antimicrobial peptide expression: Past, present and future , 2010, The Journal of Steroid Biochemistry and Molecular Biology.

[9]  E. Bae,et al.  Paricalcitol attenuates cyclosporine-induced kidney injury in rats. , 2010, Kidney international.

[10]  G. Ning,et al.  Combined vitamin D analog and AT1 receptor antagonist synergistically block the development of kidney disease in a model of type 2 diabetes. , 2010, Kidney international.

[11]  D. Deb,et al.  Vitamin D receptor attenuates renal fibrosis by suppressing the renin-angiotensin system. , 2010, Journal of the American Society of Nephrology : JASN.

[12]  D. Bikle Vitamin D: newly discovered actions require reconsideration of physiologic requirements , 2010, Trends in Endocrinology & Metabolism.

[13]  Glenville Jones Editorials: Why Dialysis Patients Need Combination Therapy with Both Cholecalciferol and A Calcitriol Analogs , 2010, Seminars in dialysis.

[14]  S. Booth,et al.  Vitamins K and D status in stages 3-5 chronic kidney disease. , 2010, Clinical journal of the American Society of Nephrology : CJASN.

[15]  J. Adams,et al.  Update in vitamin D. , 2010, The Journal of clinical endocrinology and metabolism.

[16]  V. Batuman,et al.  Vitamin D: a new hope for chronic kidney disease? , 2009, Kidney international.

[17]  N. Powe,et al.  25-hydroxyvitamin D levels, race, and the progression of kidney disease. , 2009, Journal of the American Society of Nephrology : JASN.

[18]  Keith C. Norris,et al.  Chronic kidney disease, hypovitaminosis D, and mortality in the United States. , 2009, Kidney international.

[19]  J. Coombes,et al.  Time course and dose response of alpha tocopherol on oxidative stress in haemodialysis patients , 2009, BMC nephrology.

[20]  A. Reunanen,et al.  Vitamin D status and the risk of cardiovascular disease death. , 2009, American journal of epidemiology.

[21]  P. Clayton,et al.  25‐Hydroxyvitamin D levels in prevalent Australian dialysis patients , 2009, Nephrology.

[22]  S. Bevc,et al.  Vitamin D as a Novel Nontraditional Risk Factor for Mortality in Hemodialysis Patients , 2009, Therapeutic apheresis and dialysis : official peer-reviewed journal of the International Society for Apheresis, the Japanese Society for Apheresis, the Japanese Society for Dialysis Therapy.

[23]  B. Kestenbaum,et al.  25-hydroxyvitamin D levels inversely associate with risk for developing coronary artery calcification. , 2009, Journal of the American Society of Nephrology : JASN.

[24]  Z. Massy,et al.  Vitamin D affects survival independently of vascular calcification in chronic kidney disease. , 2009, Clinical journal of the American Society of Nephrology : CJASN.

[25]  N. Vaziri,et al.  Antioxidant therapy does not ameliorate oxidative stress and inflammation in patients with end-stage renal disease. , 2009, Journal of the National Medical Association.

[26]  Jongha Park,et al.  Vitamin D Levels and Their Relationship with Cardiac Biomarkers in Chronic Hemodialysis Patients , 2009, Journal of Korean medical science.

[27]  B. Haditsch,et al.  Antioxidant Status of Patients on Peritoneal Dialysis: Associations with Inflammation and Glycoxidative Stress , 2009, Peritoneal dialysis international : journal of the International Society for Peritoneal Dialysis.

[28]  C. Frampton,et al.  Interrelationships between B-Type Natriuretic Peptides and Vitamin D in Patients on Maintenance Peritoneal Dialysis , 2008, Peritoneal dialysis international : journal of the International Society for Peritoneal Dialysis.

[29]  C. Chazot,et al.  Daily oral 25-hydroxycholecalciferol supplementation for vitamin D deficiency in haemodialysis patients: effects on mineral metabolism and bone markers. , 2008, Nephrology, dialysis, transplantation : official publication of the European Dialysis and Transplant Association - European Renal Association.

[30]  G. Ning,et al.  Combination therapy with AT1 blocker and vitamin D analog markedly ameliorates diabetic nephropathy: Blockade of compensatory renin increase , 2008, Proceedings of the National Academy of Sciences.

[31]  W. März,et al.  Association of vitamin D deficiency with heart failure and sudden cardiac death in a large cross-sectional study of patients referred for coronary angiography. , 2008, The Journal of clinical endocrinology and metabolism.

[32]  R. Heaney Vitamin D: criteria for safety and efficacy. , 2008, Nutrition reviews.

[33]  V. Spustová,et al.  Effects of Long-Term Cholecalciferol Supplementation on Mineral Metabolism and Calciotropic Hormones in Chronic Kidney Disease , 2008, Kidney and Blood Pressure Research.

[34]  S. Draibe,et al.  Vitamin D status of chronic kidney disease patients living in a sunny country. , 2008, Journal of renal nutrition : the official journal of the Council on Renal Nutrition of the National Kidney Foundation.

[35]  B. Astor,et al.  25-hydroxyvitamin D levels and the risk of mortality in the general population. , 2008, Archives of internal medicine.

[36]  Glenville Jones Pharmacokinetics of vitamin D toxicity. , 2008, The American journal of clinical nutrition.

[37]  S. Booth,et al.  Vitamin K, circulating cytokines, and bone mineral density in older men and women. , 2008, The American journal of clinical nutrition.

[38]  E. Yetley Assessing the vitamin D status of the US population. , 2008, The American journal of clinical nutrition.

[39]  Z. Massy,et al.  Vitamin D levels and early mortality among incident hemodialysis patients. , 2008, Kidney international.

[40]  S. Booth,et al.  Vitamin K Status of Canadian Peritoneal Dialysis Patients , 2008, Peritoneal dialysis international : journal of the International Society for Peritoneal Dialysis.

[41]  L. Byham-Gray,et al.  Prevalence of vitamin D [25(OH)D] deficiency and effects of supplementation with ergocalciferol (vitamin D2) in stage 5 chronic kidney disease patients. , 2008, Journal of renal nutrition : the official journal of the Council on Renal Nutrition of the National Kidney Foundation.

[42]  B. Boehm,et al.  Independent association of low serum 25-hydroxyvitamin d and 1,25-dihydroxyvitamin d levels with all-cause and cardiovascular mortality. , 2008, Archives of internal medicine.

[43]  E. Rimm,et al.  25-hydroxyvitamin D and risk of myocardial infarction in men: a prospective study. , 2008, Archives of internal medicine.

[44]  T. Eleftheriadis,et al.  Effect of One‐year Oral α‐Tocopherol Administration on the Antioxidant Defense System in Hemodialysis Patients , 2008, Therapeutic apheresis and dialysis : official peer-reviewed journal of the International Society for Apheresis, the Japanese Society for Apheresis, the Japanese Society for Dialysis Therapy.

[45]  B. Hollis,et al.  25-Hydroxylation of vitamin D3: relation to circulating vitamin D3 under various input conditions. , 2008, The American journal of clinical nutrition.

[46]  S. Booth,et al.  Effect of vitamin K supplementation on bone loss in elderly men and women. , 2008, The Journal of clinical endocrinology and metabolism.

[47]  M. Holick,et al.  Vitamin D2 is as effective as vitamin D3 in maintaining circulating concentrations of 25-hydroxyvitamin D. , 2008, The Journal of clinical endocrinology and metabolism.

[48]  M. Traber,et al.  Vitamin E revisited: do new data validate benefits for chronic disease prevention? , 2008, Current opinion in lipidology.

[49]  J. Binongo,et al.  Cholecalciferol (vitamin D3) therapy and vitamin D insufficiency in patients with chronic kidney disease: a randomized controlled pilot study. , 2008, Endocrine practice : official journal of the American College of Endocrinology and the American Association of Clinical Endocrinologists.

[50]  Michael J. Pencina,et al.  Vitamin D Deficiency and Risk of Cardiovascular Disease , 2008, Circulation.

[51]  K. Hara,et al.  Relationship between serum 1,25-dihydroxyvitamin D and mortality in patients with pre-dialysis chronic kidney disease , 2008, Clinical and Experimental Nephrology.

[52]  Y. Soyoral,et al.  Effect of Depot Oral Cholecalciferol Treatment on Secondary Hyperparathyroidism in Stage 3 and Stage 4 Chronic Kidney Diseases Patients , 2008, Renal failure.

[53]  D. Grekas,et al.  Increase in Oxidative Stress but Not in Antioxidant Capacity with Advancing Stages of Chronic Kidney Disease , 2007, American Journal of Nephrology.

[54]  I. Reid,et al.  The effects of seasonal variation of 25-hydroxyvitamin D and fat mass on a diagnosis of vitamin D sufficiency. , 2007, The American journal of clinical nutrition.

[55]  D. Hosking,et al.  Relationship between vitamin D status, parathyroid hormone levels and bone mineral density in patients with chronic kidney disease stages 3 and 4 , 2007, Nephrology.

[56]  P. Erhard,et al.  Serum vitamin E and oxidative protein modification in hemodialysis: a randomized clinical trial. , 2007, American journal of kidney diseases : the official journal of the National Kidney Foundation.

[57]  J. Zanchetta,et al.  Prevalence of 25(OH) vitamin D insufficiency and deficiency in chronic kidney disease stage 5 patients on hemodialysis , 2007, Hemodialysis international. International Symposium on Home Hemodialysis.

[58]  Raymond Vanholder,et al.  EBPG guideline on nutrition. , 2007, Nephrology, dialysis, transplantation : official publication of the European Dialysis and Transplant Association - European Renal Association.

[59]  Lisa M. Miller,et al.  Subclinical vitamin K deficiency in hemodialysis patients. , 2007, American journal of kidney diseases : the official journal of the National Kidney Foundation.

[60]  G. London,et al.  Mineral metabolism and arterial functions in end-stage renal disease: potential role of 25-hydroxyvitamin D deficiency. , 2007, Journal of the American Society of Nephrology : JASN.

[61]  Daniel O. Young,et al.  Prevalence of Vitamin D Deficiency and the Safety and Effectiveness of Monthly Ergocalciferol in Hemodialysis Patients , 2007, Nephron Clinical Practice.

[62]  S. Şen,et al.  Effect of vitamin E therapy on oxidative stress and erythrocyte osmotic fragility in patients on peritoneal dialysis and hemodialysis. , 2006, Journal of nephrology.

[63]  I. Karayaylali,et al.  Severe vitamin D deficiency in chronic renal failure patients on peritoneal dialysis. , 2006, Clinical nephrology.

[64]  S. Lanham-New,et al.  Vitamin K and the prevention of fractures: systematic review and meta-analysis of randomized controlled trials. , 2006, Archives of internal medicine.

[65]  B. Piraino,et al.  Prevalence and Correction of 25(OH) Vitamin D Deficiency in Peritoneal Dialysis Patients , 2005, Peritoneal dialysis international : journal of the International Society for Peritoneal Dialysis.

[66]  S. Moe,et al.  Prevalence of calcidiol deficiency in CKD: a cross-sectional study across latitudes in the United States. , 2005, American journal of kidney diseases : the official journal of the National Kidney Foundation.

[67]  Bess Dawson-Hughes,et al.  Fracture prevention with vitamin D supplementation: a meta-analysis of randomized controlled trials. , 2005, JAMA.

[68]  K. Kraemer,et al.  Vitamins E and C are safe across a broad range of intakes. , 2005, The American journal of clinical nutrition.

[69]  S. Yusuf,et al.  Effects of long-term vitamin E supplementation on cardiovascular events and cancer: a randomized controlled trial. , 2005, JAMA.

[70]  Y. Carpentier,et al.  Vitamin E: absorption, plasma transport and cell uptake , 2005, Current opinion in clinical nutrition and metabolic care.

[71]  D. Abramowicz,et al.  A Controlled Study of Vitamin D3 to Prevent Bone Loss in Renal-Transplant Patients Receiving Low Doses of Steroids , 2005, Transplantation.

[72]  C. Conte,et al.  Vitamin E in Uremia and Dialysis Patients , 2004, Annals of the New York Academy of Sciences.

[73]  Glenville Jones,et al.  Enzymes involved in the activation and inactivation of vitamin D. , 2004, Trends in biochemical sciences.

[74]  B. Hollis,et al.  Vitamin D2 is much less effective than vitamin D3 in humans. , 2004, The Journal of clinical endocrinology and metabolism.

[75]  D. Oliver,et al.  Vitamin D Insufficiency and Deficiency in Chronic Kidney Disease , 2004, American Journal of Nephrology.

[76]  P. Rodrigues,et al.  Metabolic Pathways and Modulating Effects of Vitamin A , 2004 .

[77]  U. Buoncristiani,et al.  Accumulation of vitamin E metabolites in the blood of renal failure patients. , 2004, Clinical nutrition.

[78]  A. Nakashima,et al.  Effects of vitamin K2 in hemodialysis patients with low serum parathyroid hormone levels. , 2004, Bone.

[79]  S. Boddupalli,et al.  Alpha and gamma tocopherol metabolism in healthy subjects and patients with end-stage renal disease. , 2003, Kidney international.

[80]  S. Booth,et al.  Dietary phylloquinone depletion and repletion in older women. , 2003, The Journal of nutrition.

[81]  T. Iwamoto,et al.  Pharmacodynamics of Menatetrenone and Effects on Bone Metabolism in Continuous Ambulatory Peritoneal Dialysis Patients , 2002, The Journal of international medical research.

[82]  P. Khajehdehi,et al.  A randomized, double-blind, placebo-controlled trial of supplementary vitamins E, C and their combination for treatment of haemodialysis cramps. , 2001, Nephrology, dialysis, transplantation : official publication of the European Dialysis and Transplant Association - European Renal Association.

[83]  A. Bendich Dietary reference intakes for vitamin C, vitamin E, selenium, and carotenoids institute of medicine washington, DC: National Academy Press, 2000 ISBN: 0-309-06935-1 , 2001 .

[84]  B. Ames,et al.  γ-Tocopherol and its major metabolite, in contrast to α-tocopherol, inhibit cyclooxygenase activity in macrophages and epithelial cells , 2000 .

[85]  M. Boaz,et al.  Secondary prevention with antioxidants of cardiovascular disease in endstage renal disease (SPACE): randomised placebo-controlled trial , 2000, The Lancet.

[86]  R. Vieth,et al.  Evidence that vitamin D3 increases serum 25-hydroxyvitamin D more efficiently than does vitamin D2. , 1998, The American journal of clinical nutrition.

[87]  S. Booth,et al.  Dietary intake and adequacy of vitamin K. , 1998, The Journal of nutrition.

[88]  D. Bonnefont-Rousselot,et al.  Antioxidant status of elderly chronic renal patients treated by continuous ambulatory peritoneal dialysis. , 1997, Nephrology, dialysis, transplantation : official publication of the European Dialysis and Transplant Association - European Renal Association.

[89]  M. Shearer,et al.  Bone health of adult hemodialysis patients is related to vitamin K status. , 1997, Kidney international.

[90]  S. Silbiger,et al.  Hypervitaminosis A in two hemodialysis patients. , 1995, American journal of kidney diseases : the official journal of the National Kidney Foundation.

[91]  R. Lauwerys,et al.  Effect of renal insufficiency on the concentration of free retinol-binding protein in urine and serum. , 1988, Clinica chimica acta; international journal of clinical chemistry.

[92]  J. Kanis,et al.  Vitamin A and hyperparathyroid bone disease in uremia. , 1983, The American journal of clinical nutrition.

[93]  T. Oppé,et al.  Vitamin D deficiency. , 1979, British medical journal.

[94]  D. Sklan,et al.  Hemodialysis: Effect on Plasma Levels of Vitamin A and Carotenoid , 1978 .

[95]  H. Yatzidis,et al.  Hypervitaminosis A in chronic renal failure after transplantation. , 1976, British medical journal.

[96]  K. Kalantar-Zadeh,et al.  Paricalcitol versus ergocalciferol for secondary hyperparathyroidism in CKD stages 3 and 4: a randomized controlled trial. , 2012, American journal of kidney diseases : the official journal of the National Kidney Foundation.

[97]  J. Moczko,et al.  Vitamin K status in peritoneally dialyzed patients with chronic kidney disease. , 2011, Acta biochimica Polonica.

[98]  J. Sim,et al.  Vitamin D supplementation and recombinant human erythropoietin utilization in vitamin D-deficient hemodialysis patients. , 2011, Journal of nephrology.

[99]  L. Snetselaar,et al.  Vitamin A and retinol intakes and the risk of fractures among participants of the Women's Health Initiative Observational Study. , 2009, The American journal of clinical nutrition.

[100]  C. Zoccali,et al.  Vitamin D levels and patient outcome in chronic kidney disease. , 2009, Kidney international.

[101]  A. Fournier,et al.  Prevalence of abnormal serum vitamin D, PTH, calcium, and phosphorus in patients with chronic kidney disease: results of the study to evaluate early kidney disease. , 2008, Kidney international.

[102]  A. Levin,et al.  Prevalence of abnormal serum vitamin D, PTH, calcium, and phosphorus in patients with chronic kidney disease: results of the study to evaluate early kidney disease. , 2007, Kidney international.

[103]  M. A. Abahusain,et al.  The Biochemical Status of Vitamin A and Alpha-tocopherol during Different Stages of Renal Disease and its Relationship to Diabetes. , 2002, Saudi journal of kidney diseases and transplantation : an official publication of the Saudi Center for Organ Transplantation, Saudi Arabia.

[104]  B. Ames,et al.  gamma-tocopherol and its major metabolite, in contrast to alpha-tocopherol, inhibit cyclooxygenase activity in macrophages and epithelial cells. , 2000, Proceedings of the National Academy of Sciences of the United States of America.

[105]  H. Reichel No effect of vitamin K1 supplementation on biochemical bone markers in haemodialysis patients. , 1999, Nephrology, dialysis, transplantation : official publication of the European Dialysis and Transplant Association - European Renal Association.

[106]  D. Cole,et al.  Evidence that vitamin D 3 increases serum 25-hydroxyvitamin D more efficiently than does vitamin D 2 1 – 3 , 2022 .

[107]  Robert M. Russell,et al.  Dietary Reference Intakes for Vitamin A , Vitamin K , Arsenic , Boron , Chromium , Copper , Iodine , Iron , Manganese , Molybdenum , Nickel , Silver , Vanadium , and Zinc , 2022 .