L1210 dihydrofolate reductase: activation and enhancement of methotrexate sensitivity.

[1]  F. M. Huennekens,et al.  Polymorphism of dihydrofolate reductase from a methotrexate-resistant subline of L1210 cells. , 1985, Advances in enzyme regulation.

[2]  R T Schimke,et al.  Gene amplification, drug resistance, and cancer. , 1984, Cancer research.

[3]  F. M. Huennekens,et al.  Multiple forms of L1210 dihydrofolate reductase differing in affinity for methotrexate. , 1984, Biochemical and biophysical research communications.

[4]  R. Schimke,et al.  Gene amplification in a single cell cycle in Chinese hamster ovary cells. , 1984, The Journal of biological chemistry.

[5]  G. Curt,et al.  Drug resistance in cancer. , 1984, Cancer treatment reports.

[6]  A. Levinson,et al.  Isolation and expression of an altered mouse dihydrofolate reductase cDNA. , 1983, Proceedings of the National Academy of Sciences of the United States of America.

[7]  A. Lambert,et al.  A sensitive silver stain for proteins in agarose gels. , 1983, Analytical biochemistry.

[8]  I. Olsson,et al.  Isoelectric focusing in agarose under denaturating conditions , 1981 .

[9]  L. Kuyper,et al.  Effect of a single amino acid substitution on Escherichia coli dihydrofolate reductase catalysis and ligand binding. , 1981, The Journal of biological chemistry.

[10]  B. Kaufman,et al.  Alteration of the properties of chicken liver dihydrofolate reductase as a result of modification by tetrathionate. , 1980, The Journal of biological chemistry.

[11]  J. Bertino.  Toward improved selectivity in cancer chemotherapy: the Richard and Hinda Rosenthal Foundation Award Lecture. , 1979, Cancer research.

[12]  A. W. Phillips,et al.  The amino acid sequence of dihydrofolate reductase from the mouse lymphoma L1210. , 1979, The Journal of biological chemistry.

[13]  F. M. Huennekens,et al.  Substrate and inhibitor complexes of dihydrofolate reductase from amethopterin-resistant L1210 cells. , 1975, Archives of biochemistry and biophysics.

[14]  F. M. Huennekens,et al.  Dihydrofolate reductase from amethopterin-resistant Lactobacillus casei. , 1972, Biochemistry.

[15]  F. M. Huennekens,et al.  Dihydrofolate Reductases: Structural and Mechanistic Aspects * , 1971, Annals of the New York Academy of Sciences.

[16]  J. Bertino,et al.  "Induction" of dihydrofolate reductase: purification and properties of the "induced" human erythrocyte and leukocyte enzyme and normal bone marrow enzyme. , 1970, Cancer research.

[17]  K. Weber,et al.  The reliability of molecular weight determinations by dodecyl sulfate-polyacrylamide gel electrophoresis. , 1969, The Journal of biological chemistry.

[18]  Raymond L. Blakley.  The biochemistry of folic acid and related pteridines , 1969 .

[19]  F. M. Huennekens,et al.  Ion-dependent activation of dihydrofolate reductase from L1210 cells. , 1967, Biochemistry.

[20]  F. M. Huennekens,et al.  Activation of dihydrofolate reductase by 5,5'-dithiobis-(2-nitrobenzoic acid). , 1967, Biochemical and biophysical research communications.

[21]  D. Hutchison,et al.  Amethopterin resistance in clonal lines of L1210 mouse leukemia: some associated biologic and biochemical alterations. , 1966, Cancer research.

[22]  J. Bertino,et al.  INTERACTION OF ORGANIC MERCURIAL COMPOUNDS WITH DIHYDROFOLATE REDUCTASE FROM EHRLICH ASCITES CARCINOMA CELLS. , 1965, Biochemistry.

[23]  B. Kaufman.  ACTIVATION OF DIHYDROFOLIC REDUCTASE BY ORGANIC MERCURIALS. , 1964, The Journal of biological chemistry.

[24]  F. M. Huennekens,et al.  Increased Level of Dihydrofolic Reductase in Leucocytes of Patients Treated with Amethopterin , 1962, Nature.

[25]  F. M. Huennekens,et al.  Enzymatic reduction of dihydrofolic acid. , 1958, The Journal of biological chemistry.

[26]  F. M. Huennekens,et al.  Inhibition of Dihydrofolic Reductase by Aminopterin and Amethopterin.∗ † , 1958, Proceedings of the Society for Experimental Biology and Medicine. Society for Experimental Biology and Medicine.

[27]  S. Futterman.  Enzymatic reduction of folic acid and dihydrofolic acid to tetrahydrofolic acid. , 1957, The Journal of biological chemistry.

[28]  C. A. Nichol.  37 – Studies on Resistance to Folic Acid Antagonists1 , 1957 .