Health benefits of dietary polyphenols: Insight into interindividual variability in absorption and metabolism

[1]  M. Lotz,et al.  Urolithin A improves mitochondrial health, reduces cartilage degeneration, and alleviates pain in osteoarthritis , 2022, Aging cell.

[2]  Sungjin Park,et al.  Naringenin and Phytoestrogen 8-Prenylnaringenin Protect against Islet Dysfunction and Inhibit Apoptotic Signaling in Insulin-Deficient Diabetic Mice , 2022, Molecules.

[3]  J. Espín,et al.  4-Hydroxydibenzyl: a novel metabolite from the human gut microbiota after consuming resveratrol. , 2022, Food & function.

[4]  S. Dou,et al.  Fermentation of soymilk by Lactobacillus acidipiscis isolated from Chinese stinky tofu capable of efficiently biotransforming isoflavone glucosides to dihydrodaidzein and dihydrogenistein. , 2022, Journal of the science of food and agriculture.

[5]  Zhirong Wang,et al.  Urolithin B suppressed osteoclast activation and reduced bone loss of osteoporosis via inhibiting ERK/NF‐κB pathway , 2022, Cell proliferation.

[6]  R. Chapkin,et al.  Personalized Nutrition Using Microbial Metabolite Phenotype to Stratify Participants and Non-Invasive Host Exfoliomics Reveal the Effects of Flaxseed Lignan Supplementation in a Placebo-Controlled Crossover Trial , 2022, Nutrients.

[7]  S. Guyot,et al.  An insight into an intriguing oxidative biotransformation pathway of 5-O-caffeoylquinic acid by a gut bacterium. , 2022, Food & function.

[8]  Hang Xiao,et al.  Gut Microbiota-Derived Resveratrol Metabolites, Dihydroresveratrol and Lunularin, Significantly Contribute to the Biological Activities of Resveratrol , 2022, Frontiers in Nutrition.

[9]  M. Portillo,et al.  Variability in the Beneficial Effects of Phenolic Compounds: A Review , 2022, Nutrients.

[10]  J. Auwerx,et al.  Urolithin A improves muscle strength, exercise performance, and biomarkers of mitochondrial health in a randomized trial in middle-aged adults , 2022, Cell reports. Medicine.

[11]  M. De Mey,et al.  In Vitro Microbial Metabolism of (+)-Catechin Reveals Fast and Slow Converters with Individual-Specific Microbial and Metabolite Markers. , 2022, Journal of agricultural and food chemistry.

[12]  A. Marette,et al.  Gut Microbial Signatures of Distinct Trimethylamine N-Oxide Response to Raspberry Consumption , 2022, Nutrients.

[13]  J. Espín,et al.  Urolithins: a Comprehensive Update on their Metabolism, Bioactivity, and Associated Gut Microbiota , 2022, Molecular nutrition & food research.

[14]  Yu Lan,et al.  Urolithin A alleviates acute kidney injury induced by renal ischemia reperfusion through the p62‐Keap1‐Nrf2 signaling pathway , 2022, Phytotherapy research : PTR.

[15]  P. Aebischer,et al.  Effect of Urolithin A Supplementation on Muscle Endurance and Mitochondrial Health in Older Adults , 2022, JAMA network open.

[16]  A. Marette,et al.  Raspberry consumption: identification of distinct immune-metabolic response profiles by whole blood transcriptome profiling. , 2022, The Journal of nutritional biochemistry.

[17]  N. M. Hassimotto,et al.  Blood pressure and body fat % reduction is mainly related to flavanone phase II conjugates and minor extension by phenolic acid after long-term intake of orange juice. , 2021, Food & function.

[18]  J. Espín,et al.  Main drivers of (poly)phenol effects on human health: metabolite production and/or gut microbiota-associated metabotypes? , 2021, Food & function.

[19]  T. van de Wiele,et al.  Gut microbiota as a driver of the interindividual variability of cardiometabolic effects from tea polyphenols , 2021, Critical reviews in food science and nutrition.

[20]  A. Morgun,et al.  Xanthohumol Requires the Intestinal Microbiota to Improve Glucose Metabolism in Diet-Induced Obese Mice. , 2021, Molecular nutrition & food research.

[21]  S. Kulling,et al.  Adlercreutzia rubneri sp. nov., a resveratrol-metabolizing bacterium isolated from human faeces and emended description of the genus Adlercreutzia , 2021, International journal of systematic and evolutionary microbiology.

[22]  Gaohua Wang,et al.  The Gut Microbiota Metabolite Urolithin B Improves Cognitive Deficits by Inhibiting Cyt C-Mediated Apoptosis and Promoting the Survival of Neurons Through the PI3K Pathway in Aging Mice , 2021, Frontiers in Pharmacology.

[23]  W. Lieb,et al.  Microbial Diversity and Abundance of Parabacteroides Mediate the Associations Between Higher Intake of Flavonoid-Rich Foods and Lower Blood Pressure , 2021, Hypertension.

[24]  Xu Lin,et al.  Gut Microbiota Composition is Associated with Responses to Peanut Intervention in Multiple Parameters Among Adults with Metabolic Syndrome Risk. , 2021, Molecular nutrition & food research.

[25]  J. Scaria,et al.  Screening of Human Gut Bacterial Culture Collection Identifies Species That Biotransform Quercetin into Metabolites with Anticancer Properties , 2021, International journal of molecular sciences.

[26]  M. Lawton,et al.  Roles of Phytoestrogen in the Pathophysiology of Intracranial Aneurysm , 2021, Stroke.

[27]  H. Ohta,et al.  Effects of an equol-containing supplement on advanced glycation end products, visceral fat and climacteric symptoms in postmenopausal women: A randomized controlled trial , 2021, PloS one.

[28]  B. Pineda,et al.  Redox and Anti-Inflammatory Properties from Hop Components in Beer-Related to Neuroprotection , 2021, Nutrients.

[29]  Xinmin Liu,et al.  S-equol, a metabolite of dietary soy isoflavones, alleviates lipopolysaccharide-induced depressive-like behavior in mice by inhibiting neuroinflammation and enhancing synaptic plasticity. , 2021, Food & function.

[30]  Li Wang,et al.  Isolation and identification of a human intestinal bacterium capable of daidzein conversion. , 2021, FEMS microbiology letters.

[31]  M. Rollo,et al.  The relationship between urinary polyphenol metabolites and dietary polyphenol intakes in young adults , 2021, British Journal of Nutrition.

[32]  Michael J. Schlicht,et al.  Soy protein supplementation in men following radical prostatectomy: a 2-year randomized, placebo-controlled clinical trial. , 2021, The American journal of clinical nutrition.

[33]  J. Pérez‐Jiménez,et al.  Inter-Individual Variability in Insulin Response after Grape Pomace Supplementation in Subjects at High Cardiometabolic Risk: Role of Microbiota and miRNA. , 2020, Molecular nutrition & food research.

[34]  C. Del Bo’,et al.  A Review of Registered Clinical Trials on Dietary (Poly)Phenols: Past Efforts and Possible Future Directions , 2020, Foods.

[35]  L. Wood,et al.  The Relationship between Dietary Polyphenol Intakes and Urinary Polyphenol Concentrations in Adults Prescribed a High Vegetable and Fruit Diet , 2020, Nutrients.

[36]  J. Simon,et al.  Microbiota metabolites modulate the T helper 17 to regulatory T cell (Th17/Treg) imbalance promoting resilience to stress-induced anxiety- and depressive-like behaviors , 2020, Brain, Behavior, and Immunity.

[37]  J. Zentek,et al.  Comparative studies of urolithins and their phase II metabolites on macrophage and neutrophil functions , 2020, European Journal of Nutrition.

[38]  Weifeng Liu,et al.  Biotransformation of dietary phytoestrogens by gut microbes: A review on bidirectional interaction between phytoestrogen metabolism and gut microbiota. , 2020, Biotechnology advances.

[39]  M. Simon,et al.  Antidiabetic Effects of Flavan-3-ols and Their Microbial Metabolites , 2020, Nutrients.

[40]  A. Rodriguez-Mateos,et al.  Kinetic profile and urinary excretion of phenyl-γ-valerolactones upon consumption of cranberry: a dose-response relationship. , 2020, Food & function.

[41]  M. Farag,et al.  How do biocatalysis and biotransformation affect Citrus dietary flavonoids chemistry and bioactivity? A review , 2020, Critical reviews in biotechnology.

[42]  J. Espín,et al.  Inhibition of 5-Lipoxygenase Derived Leukotrienes and Hemiketals as a Novel Anti-Inflammatory Mechanism of Urolithins. , 2020, Molecular nutrition & food research.

[43]  Xiaosong Hu,et al.  Resveratrol reduces obesity in high-fat diet-fed mice via modulating the structure and metabolic function of the gut microbiota. , 2020, Free radical biology & medicine.

[44]  J. Espín,et al.  Where to Look into the Puzzle of Polyphenols and Health? The Postbiotics and the Gut Microbiota Associated with Human Metabotypes. , 2020, Molecular nutrition & food research.

[45]  K. Skalicka‐Woźniak,et al.  Bioactivity of dietary polyphenols: The role of metabolites , 2020, Critical reviews in food science and nutrition.

[46]  J. Geleijnse,et al.  Inter-individual Variation in Cancer and Cardiometabolic Health Outcomes in Response to Coffee Consumption: a Critical Review. , 2020, Molecular nutrition & food research.

[47]  E. Gibney,et al.  Why interindividual variation in response to consumption of plant food bioactives matters for future personalised nutrition , 2020, Proceedings of the Nutrition Society.

[48]  Yi Chen,et al.  Soy and Isoflavone Consumption and Multiple Health Outcomes: Umbrella Review of Systematic Reviews and Meta-Analyses of Observational Studies and Randomised Trials in Humans. , 2020, Molecular nutrition & food research.

[49]  K. Lüersen,et al.  The Putative Caloric Restriction Mimetic Resveratrol has Moderate Impact on Insulin Sensitivity, Body Composition and the Metabolome in Mice. , 2020, Molecular nutrition & food research.

[50]  Bradley W. Bolling,et al.  Flavonoids and gut health. , 2020, Current opinion in biotechnology.

[51]  R. Tu,et al.  Fruit and vegetable intake modifies the associations between suppressor of cytokine signaling 3 genetic variants and type 2 diabetes , 2020, European Journal of Nutrition.

[52]  G. Forloni,et al.  Flavonoid-Derived Human Phenyl-γ-Valerolactone Metabolites Selectively Detoxify Amyloid-β Oligomers and Prevent Memory Impairment in a Mouse Model of Alzheimer's Disease. , 2020, Molecular nutrition & food research.

[53]  G. Williamson,et al.  Bioavailability and metabolism of chlorogenic acids (acyl-quinic acids) in humans. , 2020, Comprehensive reviews in food science and food safety.

[54]  S. N. El,et al.  A Review of Factors Affecting Anthocyanin Bioavailability: Possible Implications for the Inter-Individual Variability , 2019, Foods.

[55]  Li Xiaobin,et al.  Isolation and identification of an isoflavone reducing bacterium from feces from a pregnant horse , 2019, PloS one.

[56]  C. Davis,et al.  5-(Hydroxyphenyl)-γ-Valerolactone-Sulfate, a Key Microbial Metabolite of Flavan-3-ols, Is Able to Reach the Brain: Evidence from Different in Silico, In Vitro and In Vivo Experimental Models , 2019, Nutrients.

[57]  D. Milenkovic,et al.  Polyphenols in human nutrition: from the in vitro antioxidant capacity to the beneficial effects on cardiometabolic health and related inter-individual variability – an overview and perspective , 2019, British Journal of Nutrition.

[58]  F. Tomás-Barberán,et al.  Contribution of plant food bioactives in promoting health effects of plant foods: why look at interindividual variability? , 2019, European Journal of Nutrition.

[59]  E. Gibney,et al.  Targeting the delivery of dietary plant bioactives to those who would benefit most: from science to practical applications , 2019, European Journal of Nutrition.

[60]  Ž. Reiner,et al.  The effects of resveratrol on metabolic status in patients with type 2 diabetes mellitus and coronary heart disease. , 2019, Food & function.

[61]  A. Flórez,et al.  Equol: A Bacterial Metabolite from The Daidzein Isoflavone and Its Presumed Beneficial Health Effects , 2019, Nutrients.

[62]  A. Tjønneland,et al.  Flavonoid intake is associated with lower mortality in the Danish Diet Cancer and Health Cohort , 2019, Nature Communications.

[63]  E. Gibney,et al.  Impact of Foods and Dietary Supplements Containing Hydroxycinnamic Acids on Cardiometabolic Biomarkers: A Systematic Review to Explore Inter-Individual Variability , 2019, Nutrients.

[64]  H. Rupasinghe,et al.  Biotransformation of Cranberry Proanthocyanidins to Probiotic Metabolites by Lactobacillus rhamnosus Enhances Their Anticancer Activity in HepG2 Cells In Vitro , 2019, Oxidative medicine and cellular longevity.

[65]  A. Aura,et al.  Factors affecting intake, metabolism and health benefits of phenolic acids: do we understand individual variability? , 2019, European Journal of Nutrition.

[66]  Suna Kang,et al.  Lactobacillus intestinalis efficiently produces equol from daidzein and chungkookjang, short-term fermented soybeans , 2019, Archives of Microbiology.

[67]  M. Chou,et al.  Genetic and Non-Genetic Factor-Adjusted Association between Coffee Drinking and High-Density Lipoprotein Cholesterol in Taiwanese Adults: Stratification by Sex , 2019, Nutrients.

[68]  A. Flórez,et al.  Transcriptional Regulation of the Equol Biosynthesis Gene Cluster in Adlercreutzia equolifaciens DSM19450T , 2019, Nutrients.

[69]  R. Landberg,et al.  Factors Explaining Interpersonal Variation in Plasma Enterolactone Concentrations in Humans , 2019, Molecular nutrition & food research.

[70]  F. Tomás-Barberán,et al.  Interindividual Variability in Absorption, Distribution, Metabolism, and Excretion of Food Phytochemicals Should Be Reported. , 2019, Journal of agricultural and food chemistry.

[71]  J. F. Stevens,et al.  Antiproliferative and Cytotoxic Activity of Xanthohumol and Its Non-Estrogenic Derivatives in Colon and Hepatocellular Carcinoma Cell Lines , 2019, International journal of molecular sciences.

[72]  H. Ashida,et al.  Effects of Microbial Metabolites of (-)-Epigallocatechin Gallate on Glucose Uptake in L6 Skeletal Muscle Cell and Glucose Tolerance in ICR Mice. , 2019, Biological & pharmaceutical bulletin.

[73]  D. Bravo,et al.  Influence of different lignan compounds on enterolignan production by Bifidobacterium and Lactobacillus strains. , 2019, International journal of food microbiology.

[74]  J. Bolton,et al.  The Multiple Biological Targets of Hops and Bioactive Compounds. , 2019, Chemical research in toxicology.

[75]  J. F. Stevens,et al.  Reductive Metabolism of Xanthohumol and 8‐Prenylnaringenin by the Intestinal Bacterium Eubacterium ramulus , 2018, Molecular nutrition & food research.

[76]  J. Vincken,et al.  Green and Black Tea Phenolics: Bioavailability, Transformation by Colonic Microbiota, and Modulation of Colonic Microbiota. , 2018, Journal of agricultural and food chemistry.

[77]  G. Borge,et al.  Bioavailability of Quercetin in Humans with a Focus on Interindividual Variation. , 2018, Comprehensive reviews in food science and food safety.

[78]  J. Espín,et al.  Ellagibacter isourolithinifaciens gen. nov., sp. nov., a new member of the family Eggerthellaceae, isolated from human gut. , 2018, International journal of systematic and evolutionary microbiology.

[79]  Donghyuk Kim,et al.  Isolation and identification of new bacterial stains producing equol from Pueraria lobata extract fermentation , 2018, PloS one.

[80]  J. Espín,et al.  Isolation of Human Intestinal Bacteria Capable of Producing the Bioactive Metabolite Isourolithin A from Ellagic Acid , 2017, Front. Microbiol..

[81]  F. Ricceri,et al.  Identification of Urinary Polyphenol Metabolite Patterns Associated with Polyphenol-Rich Food Intake in Adults from Four European Countries , 2017, Nutrients.

[82]  R. de Caterina,et al.  Interindividual Variability in Biomarkers of Cardiometabolic Health after Consumption of Major Plant-Food Bioactive Compounds and the Determinants Involved , 2017, Advances in nutrition.

[83]  A. Flórez,et al.  Development and Use of a Real-Time Quantitative PCR Method for Detecting and Quantifying Equol-Producing Bacteria in Human Faecal Samples and Slurry Cultures , 2017, Front. Microbiol..

[84]  J. Espín,et al.  Clustering according to urolithin metabotype explains the interindividual variability in the improvement of cardiovascular risk biomarkers in overweight‐obese individuals consuming pomegranate: A randomized clinical trial , 2017, Molecular nutrition & food research.

[85]  M. Garcia-Conesa,et al.  Gene expression changes in colon tissues from colorectal cancer patients following the intake of an ellagitannin-containing pomegranate extract: a randomized clinical trial. , 2017, The Journal of nutritional biochemistry.

[86]  F. Ricceri,et al.  Urinary excretions of 34 dietary polyphenols and their associations with lifestyle factors in the EPIC cohort study , 2016, Scientific Reports.

[87]  Tohru Suzuki,et al.  The production of S-equol from daidzein is associated with a cluster of three genes in Eggerthella sp. YY7918 , 2016, Bioscience of microbiota, food and health.

[88]  Z. Bian,et al.  Inhibition of pancreatic oxidative damage by stilbene derivative dihydro-resveratrol: implication for treatment of acute pancreatitis , 2016, Scientific Reports.

[89]  A. Minihane,et al.  Acute benefits of the microbial-derived isoflavone metabolite equol on arterial stiffness in men prospectively recruited according to equol producer phenotype: a double-blind randomized controlled trial12 , 2016, The American journal of clinical nutrition.

[90]  F. Rafii.  The Role of Colonic Bacteria in the Metabolism of the Natural Isoflavone Daidzin to Equol , 2015, Metabolites.

[91]  J. Espín,et al.  Description of urolithin production capacity from ellagic acid of two human intestinal Gordonibacter species. , 2014, Food & function.

[92]  Akiko Takagaki,et al.  Isolation and characterization of rat intestinal bacteria involved in biotransformation of (−)-epigallocatechin , 2014, Archives of Microbiology.

[93]  Meng Li,et al.  Study on human intestinal bacterium Blautia sp. AUH-JLD56 for the conversion of arctigenin to (-)-3'-desmethylarctigenin. , 2013, Journal of agricultural and food chemistry.

[94]  S. Uchiyama,et al.  Isolation and characterization of novel S-equol-producing bacteria from brines of stinky tofu, a traditional fermented soy food in Taiwan , 2013, International journal of food sciences and nutrition.

[95]  Gyu-Sung Cho,et al.  In vivo and in vitro metabolism of trans-resveratrol by human gut microbiota. , 2013, The American journal of clinical nutrition.

[96]  T. Dadd,et al.  The impact of the catechol-O-methyltransferase genotype on vascular function and blood pressure after acute green tea ingestion. , 2012, Molecular nutrition & food research.

[97]  A. Braune,et al.  Isolation of catechin‐converting human intestinal bacteria , 2011, Journal of applied microbiology.

[98]  T. Dadd,et al.  The impact of the catechol-O-methyltransferase genotype on the acute responsiveness of vascular reactivity to a green tea extract , 2010, British Journal of Nutrition.

[99]  N. Miyanaga,et al.  Isolation and characterization of the equol-producing bacterium Slackia sp. strain NATTS , 2010, Archives of Microbiology.

[100]  C. Elkins,et al.  Interaction of dietary resveratrol with animal-associated bacteria. , 2009, FEMS microbiology letters.

[101]  Tohru Suzuki,et al.  Isolation and Characterization of a Novel Equol-Producing Bacterium from Human Feces , 2008, Bioscience, biotechnology, and biochemistry.

[102]  W. Verstraete,et al.  Microbial and dietary factors associated with the 8-prenylnaringenin producer phenotype: a dietary intervention trial with fifty healthy post-menopausal Caucasian women , 2007, British Journal of Nutrition.

[103]  N. Nakamura,et al.  Isolation and characterization of a human intestinal bacterium, Eubacterium sp. ARC-2, capable of demethylating arctigenin, in the essential metabolic process to enterolactone. , 2007, Biological & pharmaceutical bulletin.

[104]  T. Tsushida,et al.  Isolation of an isoflavone-metabolizing, Clostridium-like bacterium, strain TM-40, from human faeces. , 2007, Anaerobe.

[105]  H. Hur,et al.  Production of phytoestrogen S-equol from daidzein in mixed culture of two anaerobic bacteria , 2007, Archives of Microbiology.

[106]  H. Hur,et al.  Enantioselective Synthesis of S-Equol from Dihydrodaidzein by a Newly Isolated Anaerobic Human Intestinal Bacterium , 2005, Applied and Environmental Microbiology.

[107]  A. Braune,et al.  Anaerobic Degradation of Flavonoids by Clostridium orbiscindens , 2003, Applied and Environmental Microbiology.

[108]  H. Adlercreutz,et al.  Interindividual Variation in Metabolism of Soy Isoflavones and Lignans: Influence of Habitual Diet on Equol Production by the Gut Microflora , 2000, Nutrition and cancer.

[109]  J. Espín,et al.  Pharmacological Therapy Determines the Gut Microbiota Modulation by a Pomegranate Extract Nutraceutical in Metabolic Syndrome: A Randomized Clinical Trial. , 2021, Molecular nutrition & food research.

[110]  G. Pasinetti,et al.  The Role of the Gut Microbiota in the Metabolism of Polyphenols as Characterized by Gnotobiotic Mice. , 2018, Journal of Alzheimer's disease : JAD.

[111]  C. Frankenfeld.  Cardiometabolic risk and gut microbial phytoestrogen metabolite phenotypes. , 2017, Molecular nutrition & food research.

[112]  M. Garcia-Conesa,et al.  Urolithins, the rescue of "old" metabolites to understand a "new" concept: Metabotypes as a nexus among phenolic metabolism, microbiota dysbiosis, and host health status. , 2017, Molecular nutrition & food research.