Synthesis of Multi-Substituted 2-Iminopyridine by Conjugate Addition of Ethyl Cyanoacetate Derivatives to Alkynyl Imines

The synthesis of multi-substituted 2-iminopyridines by conjugate addition of ethyl cyanoacetate derivatives to alkynyl imines has been developed. The reaction of ethyl cyanoacetate derivatives with alkynyl imines provided multi-substituted 2-iminopyridines in good yields. Also described is the transformation of 2-iminopyridines into 2-aminopyridines by deprotection of the substituent on the nitrogen under acidic conditions. (© Wiley-VCH Verlag GmbH & Co. KGaA, 69451 Weinheim, Germany, 2008)

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