Transgenic ferret models define pulmonary ionocyte diversity and function

[1]  Malte D. Luecken,et al.  An integrated cell atlas of the lung in health and disease , 2023, Nature Medicine.

[2]  Xingshen Sun,et al.  rAAV-MEDIATED EDITING OF THE G551D CFTR MUTATION IN FERRET AIRWAY BASAL CELLS. , 2022, Human gene therapy.

[3]  A. Comellas,et al.  Measurement of Mucociliary Transport: Novel Application of Positron Emission Tomography , 2022, 2022 IEEE 19th International Symposium on Biomedical Imaging (ISBI).

[4]  Malte D. Luecken,et al.  An integrated cell atlas of the human lung in health and disease , 2022, bioRxiv.

[5]  Xiuzhen Huang,et al.  A suite of new Dre recombinase drivers markedly expands the ability to perform intersectional genetic targeting. , 2021, Cell stem cell.

[6]  L. Ostrowski,et al.  Secretory Cells Dominate Airway CFTR Expression and Function in Human Airway Superficial Epithelia. , 2020, American journal of respiratory and critical care medicine.

[7]  S. Khader,et al.  The protective and pathogenic roles of CXCL17 in human health and disease: Potential in respiratory medicine , 2020, Cytokine & Growth Factor Reviews.

[8]  Adam J Pawson,et al.  The IUPHAR/BPS Guide to PHARMACOLOGY in 2020: extending immunopharmacology content and introducing the IUPHAR/MMV Guide to MALARIA PHARMACOLOGY , 2019, Nucleic Acids Res..

[9]  N. Pastor-Soler,et al.  Intercalated Cells of the Kidney Collecting Duct in Kidney Physiology. , 2019, Seminars in nephrology.

[10]  Paul J. Hoffman,et al.  Comprehensive Integration of Single-Cell Data , 2018, Cell.

[11]  J. Everman,et al.  Dissecting the cellular specificity of smoking effects and reconstructing lineages in the human airway epithelium , 2019, bioRxiv.

[12]  P. Negulescu,et al.  In utero and postnatal VX-770 administration rescues multiorgan disease in a ferret model of cystic fibrosis , 2019, Science Translational Medicine.

[13]  Fabian J Theis,et al.  PAGA: graph abstraction reconciles clustering with trajectory inference through a topology preserving map of single cells , 2019, Genome Biology.

[14]  S. Tyler,et al.  Highly Efficient Transgenesis in Ferrets Using CRISPR/Cas9-Mediated Homology-Independent Insertion at the ROSA26 Locus , 2019, Scientific Reports.

[15]  Vincent A. Traag,et al.  From Louvain to Leiden: guaranteeing well-connected communities , 2018, Scientific Reports.

[16]  Aviv Regev,et al.  A revised airway epithelial hierarchy includes CFTR-expressing ionocytes , 2018, Nature.

[17]  P. Böelle,et al.  SLC26A9 Gene Is Associated With Lung Function Response to Ivacaftor in Patients With Cystic Fibrosis , 2018, Front. Pharmacol..

[18]  Allon M. Klein,et al.  A single cell atlas of the tracheal epithelium reveals the CFTR-rich pulmonary ionocyte , 2018, Nature.

[19]  Andrei Zinovyev,et al.  Robust and Scalable Learning of Complex Intrinsic Dataset Geometry via ElPiGraph , 2018, Entropy.

[20]  Fabian J Theis,et al.  SCANPY: large-scale single-cell gene expression data analysis , 2018, Genome Biology.

[21]  Yarden Katz,et al.  A single-cell survey of the small intestinal epithelium , 2017, Nature.

[22]  P. Quinton.  Both Ways at Once: Keeping Small Airways Clean. , 2017, Physiology.

[23]  M. Goodheart,et al.  Wnt Signaling Regulates Airway Epithelial Stem Cells in Adult Murine Submucosal Glands , 2016, Stem cells.

[24]  Hongmei Mou,et al.  Dual SMAD Signaling Inhibition Enables Long-Term Expansion of Diverse Epithelial Basal Cells. , 2016, Cell stem cell.

[25]  Linbo Liu,et al.  In vivo imaging of airway cilia and mucus clearance with micro-optical coherence tomography. , 2016, Biomedical optics express.

[26]  Lior Pachter,et al.  Near-optimal probabilistic RNA-seq quantification , 2016, Nature Biotechnology.

[27]  N. Joo,et al.  Glandular Proteome Identifies Antiprotease Cystatin C as a Critical Modulator of Airway Hydration and Clearance. , 2016, American journal of respiratory cell and molecular biology.

[28]  P. Quinton,et al.  Site of Fluid Secretion in Small Airways. , 2016, American journal of respiratory cell and molecular biology.

[29]  Ajit Varki,et al.  Acidic pH increases airway surface liquid viscosity in cystic fibrosis. , 2016, The Journal of clinical investigation.

[30]  David K. Meyerholz,et al.  Airway acidification initiates host defense abnormalities in cystic fibrosis mice , 2016, Science.

[31]  P. Linsley,et al.  MAST: a flexible statistical framework for assessing transcriptional changes and characterizing heterogeneity in single-cell RNA sequencing data , 2015, Genome Biology.

[32]  A. Fautrel,et al.  Transcriptomic Analysis of Trout Gill Ionocytes in Fresh Water and Sea Water Using Laser Capture Microdissection Combined with Microarray Analysis , 2015, PloS one.

[33]  P. Hwang,et al.  Osmoregulation in zebrafish: ion transport mechanisms and functional regulation , 2015, EXCLI journal.

[34]  W. Sung,et al.  Differential transcriptomic analyses revealed genes and signaling pathways involved in iono-osmoregulation and cellular remodeling in the gills of euryhaline Mozambique tilapia, Oreochromis mossambicus , 2014, BMC Genomics.

[35]  Linbo Liu,et al.  A functional anatomic defect of the cystic fibrosis airway. , 2014, American journal of respiratory and critical care medicine.

[36]  J. T. Fisher,et al.  Lung phenotype of juvenile and adult cystic fibrosis transmembrane conductance regulator-knockout ferrets. , 2014, American journal of respiratory cell and molecular biology.

[37]  G. Goss,et al.  Structure and function of ionocytes in the freshwater fish gill , 2012, Respiratory Physiology & Neurobiology.

[38]  M. Johansson,et al.  Bicarbonate and functional CFTR channel are required for proper mucin secretion and link cystic fibrosis with its mucus phenotype , 2012, The Journal of experimental medicine.

[39]  M. Welsh,et al.  Reduced Airway Surface pH Impairs Bacterial Killing in the Porcine Cystic Fibrosis Lung , 2012, Nature.

[40]  Michael R Knowles,et al.  Multiple apical plasma membrane constituents are associated with susceptibility to meconium ileus in individuals with cystic fibrosis , 2012, Nature Genetics.

[41]  J. Engelhardt,et al.  New animal models of cystic fibrosis: what are they teaching us? , 2011, Current opinion in pulmonary medicine.

[42]  N. Papalopulu,et al.  Embryonic frog epidermis: a model for the study of cell-cell interactions in the development of mucociliary disease , 2011, Disease Models & Mechanisms.

[43]  N. Joo,et al.  Disease phenotype of a ferret CFTR-knockout model of cystic fibrosis. , 2010, The Journal of clinical investigation.

[44]  E. Oermann,et al.  Local extracellular acidification caused by Ca2+-dependent exocytosis in PC12 cells. , 2008, Cell calcium.

[45]  Qi Zhou,et al.  Cloned ferrets produced by somatic cell nuclear transfer. , 2006, Developmental biology.

[46]  G. Bergström,et al.  Distal renal tubular acidosis in mice that lack the forkhead transcription factor Foxi1. , 2004, The Journal of clinical investigation.

[47]  Y. Benjamini,et al.  Controlling the false discovery rate in behavior genetics research , 2001, Behavioural Brain Research.

[48]  J. Engelhardt,et al.  Successful production of offspring after superovulation and in vitro culture of embryos from domestic ferrets (Mustela putorius furos). , 2001, Reproduction.

[49]  A S Verkman,et al.  Green fluorescent protein‐based halide indicators with improved chloride and iodide affinities , 2001, FEBS letters.

[50]  A. Verkman,et al.  Airway Surface Liquid Osmolality Measured Using Fluorophore-Encapsulated Liposomes , 2001, The Journal of general physiology.

[51]  J. Wade,et al.  Aldosterone-mediated regulation of ENaC α, β, and γ subunit proteins in rat kidney , 1999 .

[52]  R. Jaenisch,et al.  Simian virus 40 DNA sequences in DNA of healthy adult mice derived from preimplantation blastocysts injected with viral DNA. , 1974, Proceedings of the National Academy of Sciences of the United States of America.

[53]  E. Willmer,et al.  ‘Chloride secreting cells’ in the gills of fishes, with special reference to the common eel , 1932, The Journal of physiology.

[54]  James M. Wilson,et al.  Submucosal glands are the predominant site of CFTR expression in the human bronchus , 1992, Nature Genetics.

[55]  P. Prunet,et al.  Ultrastructural features of mitochondria-rich cells in stenohaline freshwater and seawater fishes. , 1990, The American journal of anatomy.